Abstract
Viral respiratory infection is thought to be the major contributing factor in the pathogenesis of bacterial sinusitis. It is still not clear why some patients suffer from recurrent sinusitis episodes, as information on the exact pathomechanism of how bacterial sinusitis develops as a complication of viral colds is still scarce. In this review, different mechanisms of how a viral infection may predispose some patients to recurrent bacterial sinusitis episodes are presented. Awareness of the fact that different mechanisms may exist behind this single diagnosis of recurrent sinusitis may be of help when diagnostic measures and treatments are planned for these patients.
Keywords: Allergic Rhinitis, Sinusitis, Chronic Fatigue Syndrome, Paranasal Sinus, Acute Otitis Medium
References and Recommended Reading
- 1.Alho OP, Jokinen K, Alho P, et al. Trends in chronic maxillary sinusitis that require surgical treatment. Int J Circumpolar Health. 1999;58:234–241. [PubMed] [Google Scholar]
- 2.European Academy of Allergology and Clinical Immunology. An excellent review on acute and chronic rhinosinusitis and nasal polyps, including epidemiologic, diagnostic, and therapeutic aspects European position paper on rhinosinusitis and nasal polyps. Rhinol Suppl. 2005;18:1–87. [PubMed] [Google Scholar]
- 3.Bhattacharyya T, Lee KH. Chronic recurrent rhinosinusitis: disease severity and clinical characterization. Laryngoscope. 2005;115:306–310. doi: 10.1097/01.mlg.0000154738.40690.dd. [DOI] [PubMed] [Google Scholar]
- 4.Turner RB. Epidemiology, pathogenesis and treatment of the common cold. Ann Allergy Asthma Immunol. 1997;78:531–540. doi: 10.1016/S1081-1206(10)63213-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Heikkinen T, Järvinen A. The common cold. Lancet. 2003;361:51–59. doi: 10.1016/S0140-6736(03)12162-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.van Kempen M, Bachert C, van Cauwenberge P. An update on the pathophysiology of rhinovirus upper respiratory tract infections. Rhinology. 1999;37:97–103. [PubMed] [Google Scholar]
- 7.Alho OP, Karttunen TJ, Karttunen R, et al. Lymphocyte and mast cell counts are increased in the nasal mucosa in symptomatic natural colds. Clin Exp Immunol. 2003;131:138–142. doi: 10.1046/j.1365-2249.2003.02037.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Bende M, Barrow I, Heptonstall J, et al. Changes in human nasal mucosa during experimental coronavirus common colds. Acta Otolaryngol. 1989;107:262–269. doi: 10.3109/00016488909127507. [DOI] [PubMed] [Google Scholar]
- 9.Doyle WJ, Skoner DP, Fireman P, et al. Rhinovirus 39 infection in allergic and nonallergic subjects. J Allergy Clin Immunol. 1992;89:968–978. doi: 10.1016/0091-6749(92)90219-R. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Eccles R, Reilly M, Eccles KS. Changes in the amplitude of the nasal cycle associated with symptoms of acute upper respiratory tract infection. Acta Otolaryngol. 1996;116:77–81. doi: 10.3109/00016489609137717. [DOI] [PubMed] [Google Scholar]
- 11.Yuta A, Doyle WJ, Gaumond E, et al. Rhinovirus infection induces mucus hypersecretion. Am J Physiol. 1998;274:1017–1023. doi: 10.1152/ajplung.1998.274.6.L1017. [DOI] [PubMed] [Google Scholar]
- 12.Alho OP. Nasal airflow, mucociliary clearance, and sinus functioning during viral colds: effects of allergic rhinitis and susceptibility to recurrent sinusitis. Am J Rhinol. 2004;18:349–355. [PubMed] [Google Scholar]
- 13.Gwaltney JM, Jr, Phillips CD, Miller RD, Riker DK. Computed tomographic study of the common cold. N Engl J Med. 1994;330:25–30. doi: 10.1056/NEJM199401063300105. [DOI] [PubMed] [Google Scholar]
- 14.Puhakka T, Makela MJ, Alanen A, et al. Sinusitis in the common cold. J Allergy Clin Immunol. 1998;102:403–408. doi: 10.1016/S0091-6749(98)70127-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Kristo A, Uhari M, Luotonen J, et al. Paranasal sinus findings in children during respiratory infection evaluated with magnetic resonance imaging. Pediatrics. 2003;111:e586–e589. doi: 10.1542/peds.111.5.e586. [DOI] [PubMed] [Google Scholar]
- 16.Pitkaranta A, Starck M, Savolainen S, et al. Rhinovirus RNA in the maxillary sinus epithelium of adult patients with acute sinusitis. Clin Infect Dis. 2001;33:909–911. doi: 10.1086/322678. [DOI] [PubMed] [Google Scholar]
- 17.Gwaltney JM Jr, Hendley JO, Phillips CD, et al. Nose blowing propels nasal fluid into the paranasal sinuses. Clin Infect Dis. 2000;30:387–391. doi: 10.1086/313661. [DOI] [PubMed] [Google Scholar]
- 18.Meltzer EO, Hamilos DL, Hadley JA, et al. Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol. 2004;114(6 Suppl):155–212. doi: 10.1016/j.jaci.2004.09.029. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 19.Gwaltney JM., Jr Acute community-acquired sinusitis. Clin Infect Dis. 1996;23:1209–1223. doi: 10.1093/clinids/23.6.1209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 20.Stammberger H. Endoscopic endonasal surgery—concepts in treatment of recurring rhinosinusitis. Part I. Anatomic and pathophysiologic considerations. Otolaryngol Head Neck Surg. 1986;94:143–147. doi: 10.1177/019459988609400202. [DOI] [PubMed] [Google Scholar]
- 21.Gwaltney JM, Wiesinger BA, Patrie JT. Acute communityacquired bacterial sinusitis: the value of antimicrobial treatment and the natural history. Clin Infect Dis. 2004;38:227–233. doi: 10.1086/380641. [DOI] [PubMed] [Google Scholar]
- 22.Monto AS, Ullman BM. Acute respiratory illness in an American community: the Tecumseh study. JAMA. 1974;227:164–169. doi: 10.1001/jama.227.2.164. [DOI] [PubMed] [Google Scholar]
- 23.Monto AS. Studies of the community and family: acute respiratory illness and infection. Epidemiol Rev. 1994;16:351–373. doi: 10.1093/oxfordjournals.epirev.a036158. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 24.Alho OP, Koivu M, Sorri M, Rantakallio P. Risk factors for recurrent acute otitis media and respiratory infection in infancy. Int J Pediatr Otorhinolaryngol. 1990;19:151–161. doi: 10.1016/0165-5876(90)90221-C. [DOI] [PubMed] [Google Scholar]
- 25.Casselbrant ML, Mandel EM, Fall PA, et al. The heritability of otitis media: a twin and triplet stydy. JAMA. 1999;282:2125–2130. doi: 10.1001/jama.282.22.2125. [DOI] [PubMed] [Google Scholar]
- 26.Ramet M, Lofgren J, Alho OP, Hallman M. Surfactant protein-A gene locus associated with recurrent otitis media. J Pediatr. 2001;138:266–268. doi: 10.1067/mpd.2001.110133. [DOI] [PubMed] [Google Scholar]
- 27.Chen Y, Dales R, Lin M. The epidemiology of chronic rhinosinusitis in Canadians. Laryngoscope. 2003;113:1199–1205. doi: 10.1097/00005537-200307000-00016. [DOI] [PubMed] [Google Scholar]
- 28.Cohen S, Tyrrell DA, Smith AP. Psychological stress and susceptibility to the common cold. N Engl J Med. 1991;325:606–612. doi: 10.1056/NEJM199108293250903. [DOI] [PubMed] [Google Scholar]
- 29.Cohen S, Doyle WJ, Skoner DP, et al. Social ties and susceptibility to the common cold. JAMA. 1997;277:1940–1944. doi: 10.1001/jama.277.24.1940. [DOI] [PubMed] [Google Scholar]
- 30.Corne JM, Marshall C, Smith S, et al. Frequency, severity, and duration of rhinovirus infections in asthmatic and nonasthmatic individuals: a longitudinal cohort study. Lancet. 2002;359:831–834. doi: 10.1016/S0140-6736(02)07953-9. [DOI] [PubMed] [Google Scholar]
- 31.Uhari M, Mottonen M. An open randomized controlled trial of infection prevention in child day-care centers. Pediatr Infect Dis J. 1999;18:672–677. doi: 10.1097/00006454-199908000-00004. [DOI] [PubMed] [Google Scholar]
- 32.Whitley RJ, Hayden FG, Reisinger KS, et al. Oral oseltamivir treatment of influenza in children. Pediatr Infect Dis J. 2001;20:127–133. doi: 10.1097/00006454-200102000-00002. [DOI] [PubMed] [Google Scholar]
- 33.Marchisio P, Cavagna R, Maspes B, et al. Efficacy of intranasal virosomal influenza vaccine in the prevention of recurrent acute otitis media in children. Clin Infect Dis. 2002;35:168–174. doi: 10.1086/341028. [DOI] [PubMed] [Google Scholar]
- 34.Hoberman A, Greenberg DP, Paradise JL, et al. Effectiveness of inactivated influenza vaccine in preventing acute otitis media in young children: a randomized controlled trial. JAMA. 2003;290:1608–1616. doi: 10.1001/jama.290.12.1608. [DOI] [PubMed] [Google Scholar]
- 35.Hament JM, Kimpen JL, Fleer A, Wolfs TF. Respiratory viral infection predisposing for bacterial disease: a concise review. FEMS Immunol Med Microbiol. 1999;26:189–195. doi: 10.1111/j.1574-695X.1999.tb01389.x. [DOI] [PubMed] [Google Scholar]
- 36.Alho OP, Karttunen R, Karttunen TJ. Nasal mucosa in natural colds: effects of allergic rhinitis and susceptibility to recurrent sinusitis. Clin Exp Immunol. 2004;137:366–372. doi: 10.1111/j.1365-2249.2004.02530.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 37.Jeney EV, Raphael GD, Meredith SD, Kaliner MA. Abnormal nasal glandular secretion in recurrent sinusitis. J Allergy Clin Immunol. 1990;86:10–18. doi: 10.1016/S0091-6749(05)80117-4. [DOI] [PubMed] [Google Scholar]
- 38.Turner BW, Cail WS, Hendley JO, et al. Physiologic abnormalities in the paranasal sinuses during experimental rhinovirus colds. J Allergy Clin Immunol. 1992;90:474–478. doi: 10.1016/0091-6749(92)90172-X. [DOI] [PubMed] [Google Scholar]
- 39.Alho OP, Jokinen K, Laitinen J, et al. The common cold in patients with a history of recurrent sinusitis. Increased symptoms and radiological sinusitis-like findings. J Fam Pract. 2001;50:26–31. [PubMed] [Google Scholar]
- 40.Alho OP. Paranasal sinus bony structures and sinus functioning during viral colds in subjects with and without a history of recurrent sinusitis. Laryngoscope. 2003;113:2163–2168. doi: 10.1097/00005537-200312000-00022. [DOI] [PubMed] [Google Scholar]
- 41.Brook I, Frazier EH. Microbiology of recurrent acute rhinosinusitis. Laryngoscope. 2004;114:129–131. doi: 10.1097/00005537-200401000-00023. [DOI] [PubMed] [Google Scholar]
- 42.Custovic A, Murray C, Simpson A. Allergy and infection: understanding their relationship. Allergy. 2005;60(Suppl79):10–13. doi: 10.1111/j.1398-9995.2005.00851.x. [DOI] [PubMed] [Google Scholar]
- 43.Alho OP, Karttunen TJ, Karttunen R, et al. Subjects with allergic rhinitis show signs of more severely impaired paranasal sinus functioning during viral colds than nonallergic subjects. Allergy. 2003;58:767–771. doi: 10.1034/j.1398-9995.2003.00252.x. [DOI] [PubMed] [Google Scholar]
- 44.Engels EA, Terrin N, Barza M, Lau J. Meta-analysis of diagnostic tests for acute sinusitis. J Clin Epidemiol. 2000;53:852–862. doi: 10.1016/S0895-4356(00)00209-2. [DOI] [PubMed] [Google Scholar]
- 45.Baraniuk J, Petrie K, Le U, et al. Neuropathology in rhinosinusitis. Am J Repir Crit Care Med. 2005;171:5–11. doi: 10.1164/rccm.200403-357OC. [DOI] [PubMed] [Google Scholar]
- 46.Blomgren K, Alho OP, Ertama L, et al. Acute sinusitis: Finnish clinical practice guidelines. Scand J Infect Dis. 2005;37:245–250. [PubMed] [Google Scholar]
- 47.Jones NS. Midfacial segment pain: implications for rhinitis and sinusitis. Curr Allergy Asthma Rep. 2004;4:187–192. doi: 10.1007/s11882-004-0025-1. [DOI] [PubMed] [Google Scholar]
- 48.Benninger MS, Ferguson B, Hadley JA, et al. Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg. 2003;129(Suppl 3):1–32. doi: 10.1053/hn.2003.v128.amhn0312811. [DOI] [PubMed] [Google Scholar]