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. 2010 Nov 19;36(6):771–778. doi: 10.1134/S1068162010060142

Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses

O B Kazakova 1,✉, N I Medvedeva 1, I P Baikova 1, G A Tolstikov 1, T V Lopatina 1, M S Yunusov 1, L Zaprutko 2
PMCID: PMC7089435  PMID: 32214780

Abstract

The synthesis of a new group of triterpenoid acylates has been conducted on the basis of oleanolic, glycyrrhetic, and ursolic acids and betulin. 28-ortho-Methoxycynnamoylbetulin has been demonstrated to possess high activity against the influenza type A (H1N1) virus with the selectivity index SI > 100 while studying the activity of the synthesized compounds in relation to the reproduction of viral pathogens of respiratory infections. The high activity of 3,28-dinicotinoylbetulin against the papilloma virus (strain HPV-11) was detected with the selectivity index SI 35.

Keywords: triterpenoids, antiviral activity

Footnotes

Original Russian Text © O.B. Kazakova, N.I. Medvedeva, I.P. Baikova, G.A. Tolstikov, T.V. Lopatina, M.S. Yunusov, L. Zaprutko, 2010, published in Bioorganicheskaya Khimiya, 2010, Vol. 36, No. 6, pp. 841–848.

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