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. 2008 Oct 16;10(5):410. doi: 10.1007/s11906-008-0076-0

Pharmacologic modulation of ACE2 expression

María José Soler, Clara Barrios, Raymond Oliva, Daniel Batlle 1,✉
PMCID: PMC7089438  PMID: 18775121

Abstract

Angiotensin-converting enzyme 2 (ACE2) is an enzymatically active homologue of angiotensin-converting enzyme that degrades angiotensin I, angiotensin II, and other peptides. Recent studies have shown that under pathologic conditions, ACE2 expression in the kidney is altered. In this review, we briefly summarize recent studies dealing with pharmacologic interventions that modulate ACE2 expression. ACE2 amplification may have a potential therapeutic role for kidney disease and hypertension.

Keywords: Telmisartan, Olmesartan, Eplerenone, ACE2 Activity, ACE2 Protein

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