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. 2018 Oct 15;12(2):247–264. doi: 10.1007/s12274-018-2209-3

Graphene-based nanomaterials in biosystems

Na Lu 1, Liqian Wang 2, Min Lv 2, Zisheng Tang 3,4,5,✉, Chunhai Fan 2,6,✉
PMCID: PMC7090610  PMID: 32218914

Abstract

Graphene-based nanomaterials have emerged as a novel type of materials with exceptional physicochemical properties and numerous applications in various areas. In this review, we summarize recent advances in studying interactions between graphene and biosystems. We first provide a brief introduction on graphene and its derivatives, and then discuss on the toxicology and biocompatibility of graphene, including the extracellular interactions between graphene and biomacromolecules, cellular studies of graphene, and in vivo toxicological effects. Next, we focus on various graphene-based practical applications in antibacterial materials, wound addressing, drug delivery, and water purification. We finally present perspectives on challenges and future developments in these exciting fields.

Keywords: graphene-based nanomaterials, toxicology and biocompatibility, biomacromolecules, cells, living entities, applications

Acknowledgements

This work was financially supported by the National Key Research and Development Program (No. 2016YFA0201200), the Shanghai Municipal Natural Science Foundation (No. 17ZR1412100), the Key Laboratory of Interfacial Physics and Technology, the Chinese Academy of Sciences (No. CASKL-IPT1603), the Talent Program of Shanghai University of Engineering Science, the Startup Foundation for Doctors of Shanghai University of Engineering Science, and the National Natural Science Foundation of China (Nos. 81870749, 21373260, 31470960 and 51375294).

Contributor Information

Zisheng Tang, Email: tangzisheng163@163.com.

Chunhai Fan, Email: fchh@sinap.ac.cn, Email: fanchunhai@sjtu.edu.cn.

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