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. 2013 Jan 16;28(1):3–15. doi: 10.1007/s12250-013-3294-9

An overview of the highly pathogenic H5N1 influenza virus

Jingchuan Yin 1, Shi Liu 1, Ying Zhu 1,✉
PMCID: PMC7090813  PMID: 23325419

Abstract

Since the first human case of H5N1 avian influenza virus infection was reported in 1997, this highly pathogenic virus has infected hundreds of people around the world and resulted in many deaths. The ability of H5N1 to cross species boundaries, and the presence of polymorphisms that enhance virulence, present challenges to developing clear strategies to prevent the pandemic spread of this highly pathogenic avian influenza (HPAI) virus. This review summarizes the current understanding of, and recent research on, the avian influenza H5N1 virus, including transmission, virulence, pathogenesis, clinical characteristics, treatment and prevention.

Keywords: Avian influenza, H5N1, Transmission, Virulence, Pathogenesis

Footnotes

Foundation items: National Natural Science Foundation of China (30979144 and 81271821).

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