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. 2013 Apr 26;51(3):389–393. doi: 10.1007/s12275-013-2683-y

The effect of dietary intake of the acidic protein fraction of bovine colostrum on influenza A (H1N1) virus infection

Mei Ling Xu 1, Hyoung Jin Kim 1, Don Yong Chang 1, Hong-Jin Kim 1,✉
PMCID: PMC7090844  PMID: 23620352

Abstract

Acidic protein levels in the milk decrease markedly as lactation progresses, suggesting that it is an important part of the colostrum. However, little attention has been paid to their biological function. In this study, we isolated the acidic protein fraction of bovine colostrum (AFC, isoelectric point <5) by anion-exchange chromatography, and investigated the effect of its dietary intake on influenza A (H1N1) virus infection. 100% of mice infected with 1 LD50 of the virus survived when administered AFC for 14 days prior to infection, compared with 33% survival when administered phosphate buffered saline (PBS). Moreover, consumption of AFC reduced the weight loss associated with infection. We propose that dietary intake of AFC has a prophylactic effect on influenza A virus infection.

Electronic Supplementary Material

Supplementary material is available for this article at 10.1007/s12275-013-2683-y and is accessible for authorized users.

Keywords: bovine colostrums, acidic protein, dietary intake, influenza A virus

Electronic supplementary material

12275_2013_2683_MOESM1_ESM.pdf (159.1KB, pdf)

Supplementary material, approximately 159 KB.

Footnotes

Supplemental material for this article may be found at http://www.springer.com/content/120956.

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12275_2013_2683_MOESM1_ESM.pdf (159.1KB, pdf)

Supplementary material, approximately 159 KB.

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