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. 2012 Feb 2;35(1):77–85. doi: 10.1007/s12272-012-0108-9

Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV)

Hye Ri Park 1, Hyunjun Yoon 1, Mi Kyoung Kim 1, Sung Dae Lee 2, Youhoon Chong 1,3,✉
PMCID: PMC7090976  PMID: 22297745

Abstract

Aryl diketoacid (ADK) is well known for antiviral activity which can be enhanced by introduction of an aromatic arylmethyl substituent. A natural flavonoid quercetin has a 3,5-dihydroxychromone pharmacophore which is in bioisosteric relationship with the 1,3-diketoacid moiety of the ADK. Thus, it was of our interest to test the antiviral activity of the quercetin derivatives with an arylmethyl group attached. In this study, we prepared a series of the 7-O-arylmethylquercetin derivatives with various aromatic substituents and evaluated their antiviral activity against the SARS-associated coronavirus (SARS-CoV, SCV) as well as hepatitis C virus (HCV). Single difference in the aromatic substituent fine-tuned the biological activity of the 7-O-arylmethylquercetin derivatives to result in two different classes of derivatives selectively active against SCV and HCV.

Key words: Quercetin, Arylmethyl, Hepatitis C, Severe acute respiratory syndrome (SARS)

Footnotes

These authors contributed equally to this work.

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