Acute bronchitis: State of the art diagnosis and therapy

Fernando J Martinez

doi:10.1007/s12019-004-0025-z

. 2004;30(1):55–69. doi: 10.1007/s12019-004-0025-z

Acute bronchitis: State of the art diagnosis and therapy

Fernando J Martinez ^1,^✉

PMCID: PMC7091331 PMID: 15162593

Abstract

In managing acute bronchitis, pneumonia or an exacerbation of underlying chronic bronchitis should be excluded. Simple bronchitis is best treated symptomatically while an exacerbation of chronic bronchitis can be treated with antibiotics. Broad spectrum antibiotics are appropriate in selected patients.

Keywords: Chronic Obstructive Pulmonary Disease, Respiratory Syncytial Virus, Bronchitis, Chronic Bronchitis, Respir Crit

Footnotes

The author has stated that he does not have a significant financial interest or other relationship with any product manufacturer or provider of services discussed in this article. The author also does not discuss the use of off-label products, which includes unlabeled, unapproved, or investigative products or devices.

References

1.Knutson D, Braun C. Diagnosis and management of acute bronchitis. Am Fam Phy. 2002;65:2039–44. [PubMed] [Google Scholar]
2.Gonzales R, Sande MA. Uncomplicated acute bronchitis. Ann Intern Med. 2000;133:981–91. doi: 10.7326/0003-4819-133-12-200012190-00014. [DOI] [PubMed] [Google Scholar]
3.Steinman MA, Landefeld CS, Gonzales R. Predictors of broad-spectrum antibiotic prescribing for acute respiratory tract infections in adult primary care. JAMA. 2003;289:719–25. doi: 10.1001/jama.289.6.719. [DOI] [PubMed] [Google Scholar]
4.Gonzales R, Steiner JF, Sande MA. Antibiotic prescribing for adults with colds, upper respiratory tract infections, and bronchitis by ambulatory care physicians. JAMA. 1997;278:901–4. doi: 10.1001/jama.278.11.901. [DOI] [PubMed] [Google Scholar]
5.Cantrell R, Young AF, Martin BC. Antibiotic prescribing in ambulatory care settings for adults with colds, upper respiratory tract infections, and bronchitis. Clin Ther. 2002;24:170–82. doi: 10.1016/S0149-2918(02)85013-5. [DOI] [PubMed] [Google Scholar]
6.Niederman MS, McCombs JS, Unger AN, Kumar A, Popovian R. Treatment cost of acute exacerbations of chronic bronchitis. Clin Therapeut. 1999;21:576–91. doi: 10.1016/S0149-2918(00)88310-1. [DOI] [PubMed] [Google Scholar]
7.Hall CB, Geiman JM, Biggar R, Kotok KI, Hogan PM, Douglas GR., Jr. Respiratory syncytial virus infection within families. N Engl J Med. 1976;294:414–9. doi: 10.1056/NEJM197602192940803. [DOI] [PubMed] [Google Scholar]
8.Falsey AR, Walsh EE. Respiratory syncytial virus infection in adults. Clin Microbiol Rev. 2000;13:371–84. doi: 10.1128/CMR.13.3.371-384.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
9.Dowell SF, Anderson LJ, Gary HEJ, Erdman DD, Plouffe JF, File TM., Jr. Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults. J Infect Dis. 1996;174:456–62. doi: 10.1093/infdis/174.3.456. [DOI] [PubMed] [Google Scholar]
10.Falsey AR, Cunningham CK, Barker WH, et al. Respiratory syncytial virus and influenza A infections in the hospitalized elderly. J Infect Dis. 1995;172:389–94. doi: 10.1093/infdis/172.2.389. [DOI] [PubMed] [Google Scholar]
11.Monto AS, Gravenstein S, Elliott M, Colopy M, Schweinle J. Clinical signs and symptoms predicting influenza infection. Arch Intern Med. 2000;160:3243–7. doi: 10.1001/archinte.160.21.3243. [DOI] [PubMed] [Google Scholar]
12.Macfarlane JT, Colville A, Guion A, Macfarlane RM, Rose EH. Prospective study of aetiology and outcome of adult lower-respiratory-tract infections in the community. Lancet. 1993;341:511–514. doi: 10.1016/0140-6736(93)90275-L. [DOI] [PubMed] [Google Scholar]
13.Macfarlane J, Holmes W, Gard P, et al. Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community. Thorax. 2001;56:109–14. doi: 10.1136/thorax.56.2.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
14.Hament JM, Kimpen JLL, Fleer A, Wolfs TFW. Respiratory viral infection predisposing for bacterial disease: A concise review. FEMS Immunol Med Microbiol. 1999;26:189–95. doi: 10.1111/j.1574-695X.1999.tb01389.x. [DOI] [PubMed] [Google Scholar]
15.Hahn DL, Azenabor AA, Beatty WL, Byrne GI. Chlamydia pneumoniae as a respiratory pathogen. Front Biosci. 2002;7:66–76. doi: 10.2741/hahn. [DOI] [PubMed] [Google Scholar]
16.von Konig CHW, Halperin S, Riffelmann M, Guiso N. Pertussis of adults and infants. Lancet Inf Dis. 2002;2:744–50. doi: 10.1016/S1473-3099(02)00452-8. [DOI] [PubMed] [Google Scholar]
17.Anonymous. Resurgence of pertussis United States, 1993. MMWR Morb Mortal Wkly Rep. 1993;42:952-3/959-60. [PubMed]
18.Metlay JP, Kapoor WN, Fine JM. Does this patient have community-acquired pneumonia? diagnosing pneumonia by history and physical examination. JAMA. 1997;278:1440–5. doi: 10.1001/jama.278.17.1440. [DOI] [PubMed] [Google Scholar]
19.Metlay JP, Fine MJ. Testing strategies in the initial management of patients with community-acquired pneumonia. Ann Intern Med. 2003;138:109–18. doi: 10.7326/0003-4819-138-2-200301210-00012. [DOI] [PubMed] [Google Scholar]
20.Ruiz M, Arosio C, Salman P, Bauer TT, Torres A. Diagnosis of pneumonia and monitoring of infection eradication. Drugs. 2000;60:1289–302. doi: 10.2165/00003495-200060060-00004. [DOI] [PubMed] [Google Scholar]
21.McFadden JP, Price RC, Eastwood HD, Briggs RS. Raised respiratory rate in elderly patients: A valuable physical sign. Br Med J. 1982;284:626–7. doi: 10.1136/bmj.284.6316.626. [DOI] [PMC free article] [PubMed] [Google Scholar]
22.Metlay JP, Schulz R, Li YH, et al. Influence of age on symptoms at presentation in patients with community-acquired pneumonia. Arch Intern Med. 1997;157:1453–9. doi: 10.1001/archinte.157.13.1453. [DOI] [PubMed] [Google Scholar]
23.Seppa Y, Bloigu A, Honkanen PO, Miettinen L, Syrjala H. Severity assessment of lower respiratory tract infection in elderly patients in primary care. Arch Intern Med. 2001;161:2709–13. doi: 10.1001/archinte.161.22.2709. [DOI] [PubMed] [Google Scholar]
24.Wipf JE, Lipsky BJ, Hirschmann JV, et al. Diagnosing pneumonia by physical examination. Relevant or relic? Arch Intern Med. 1999;59:1082–7. doi: 10.1001/archinte.159.10.1082. [DOI] [PubMed] [Google Scholar]
25.Dumyati G, Falsey AR. Antivirals for influenza. What is their role in the older patient? Drugs Aging. 2002;19:777–86. doi: 10.2165/00002512-200219100-00006. [DOI] [PubMed] [Google Scholar]
26.Bloivin G, Hardy I, Tellier G, Mazaide J. Predicting influenza infections during epidemics with use of a clinical case definition. Clin Inf Dis. 2003;31:1166–9. doi: 10.1086/317425. [DOI] [PubMed] [Google Scholar]
27.Walsh EE, Cox C, Falsey AR. Clinical features of influenza A virus infection in older hospitalized persons. J Am Geriatr Soc. 2002;50:1498–503. doi: 10.1046/j.1532-5415.2002.50404.x. [DOI] [PubMed] [Google Scholar]
28.Neuzil KM, O’Connor TZ, Gorse GJ, Nichol KL. Recognizing influenza in older patients with chronic obstructive pulmonary disease who have received influenza vaccine. Clin Inf Dis. 2003;36:169–74. doi: 10.1086/345668. [DOI] [PubMed] [Google Scholar]
29.Irwin RS, Boulet LP, Cloutier MM, et al. Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians. Chest. 1998;114:133S–81S. doi: 10.1378/chest.114.2_supplement.133s. [DOI] [PubMed] [Google Scholar]
30.Williamson HA., Jr. Pulmonary function tests in acute bronchitis: Evidence for reversible airflow obstruction. J Fam Pract. 1987;3:251–6. [PubMed] [Google Scholar]
31.Boldy DA, Skidmore SJ, Ayres JG. Acute bronchitis in the community: Clinical features, infective factors, changes in pulmonary function and bronchial reactivity to histamine. Respir Med. 1990;84:377–85. doi: 10.1016/S0954-6111(08)80072-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
32.Jonsson JS, Gislason T, Gislason D, Sigurdsson JA. Acute bronchitis and clinical outcome three years later: Prospective cohort study. BMJ. 1998;317:1433–1433. doi: 10.1136/bmj.317.7170.1433. [DOI] [PMC free article] [PubMed] [Google Scholar]
33.Metlay JP, Stafford RS, Singer DE. National trends in the use of antibiotics by primary care physicians for adult patients with cough. Arch Intern Med. 1998;158:1813–8. doi: 10.1001/archinte.158.16.1813. [DOI] [PubMed] [Google Scholar]
34.Dosh SA, Hickner J, Mainous AG, III, Ebell MH. Predictors of antibiotic prescribing for nonspecific upper respiratory infections, acute bronchitis, and acute sinusitis: An UPRNet study. J Fam Pract. 2000;49:407–14. [PubMed] [Google Scholar]
35.Hueston WJ, Hopper JE, Dacus EN, Mainous AG., III Why are antibiotics prescribed for patients with acute bronchitis? A postintervention analysis. J Am Board Fam Pract. 2000;13:398–402. doi: 10.3122/15572625-13-6-398. [DOI] [PubMed] [Google Scholar]
36.Linder JA, Sim I. Antibiotic treatment of acute bronchitis in smokers. A systematic review. J Gen Intern Med. 2002;17:230–4. doi: 10.1046/j.1525-1497.2002.10405.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
37.Gonzales R, Bartlett JG, Besser RE, et al. Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: Background. Ann Emerg Med. 2001;37:720–7. doi: 10.1067/mem.2001.em376720. [DOI] [PMC free article] [PubMed] [Google Scholar]
38.Macfarlane J, Holmes W, Gard P, Thornhill D, Macfarlane R, Hubbard R. Reducing antibiotic use for acute bronchitis in primary care: blinded randomised controlled trial of patient information leaflet. BMJ. 2002;324:1–6. doi: 10.1136/bmj.324.7329.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
39.Gonzales R, Steiner JF, Lum A, Barrett PH., Jr. Decreasing antibiotic use in ambulatory practice. Impact of a multidimensional intervention on the treatment of uncomplicated acute bronchitis in adults. JAMA. 1999;281:1512–9. doi: 10.1001/jama.281.16.1512. [DOI] [PubMed] [Google Scholar]
40.Gonzales R, Steiner JF, Maselli J, Lum A, Barrett PH. Impact of reducing antibiotic prescribing for acute bronchitis on patient satisfaction. Eff Clin Pract. 2001;4:105–11. [PubMed] [Google Scholar]
41.Hueston WJ. A comparison of albuterol and erythromycin for the treatment of acute bronchitis. J Fam Pract. 1991;33:476–80. [PubMed] [Google Scholar]
42.Smucny JJ, Flynn CA, Becker LA, Glazier RH. Are β2-agonists effective treatment for acute bronchitis or acute cough in patients without underlying pulmonary disease? A systematic review. J Fam Pract. 2001;50:945–51. [PubMed] [Google Scholar]
43.Melbye H, Aasebo U, Straume B. Symptomatic effect of inhaled fenoterol in acute bronchitis: A placebo-controlled double-blind study. Fam Pract. 1991;8:216–22. doi: 10.1093/fampra/8.3.216. [DOI] [PubMed] [Google Scholar]
44.Sethi S, Murphy TF. Bacterial infection in chronic obstructive pulmonary disease in 2000: A state-of-the-art review. Clin Microbiol Rev. 2001;14:336–63. doi: 10.1128/CMR.14.2.336-363.2001. [DOI] [PMC free article] [PubMed] [Google Scholar]
45.White AJ, Gompertz S, Stockley RA. Chronic obstructive pulmonary disease 6: The etiology of exacerbations of chronic obstructive pulmonary disease. Thorax. 2003;58:73–80. doi: 10.1136/thorax.58.1.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
46.Miravitlles M. Exacerbations of chronic obstructive pulmonary disease: When are bacteria important? Eur Respir J. 2002;20(Suppl 36):9S–19S. doi: 10.1183/09031936.02.00400302. [DOI] [PubMed] [Google Scholar]
47.Wilson R. Bacteria, antibiotics and COPD. Eur Respir J. 2001;17:995–1007. doi: 10.1183/09031936.01.17509950. [DOI] [PubMed] [Google Scholar]
48.Monso E, Ruiz J, Rosell A, et al. Bacterial infection in chronic obstructive pulmonary disease: A study of stable and exacerbated outpatients using the protected specimen brush. Am J Respir Crit Care Med. 1995;152:1316–20. doi: 10.1164/ajrccm.152.4.7551388. [DOI] [PubMed] [Google Scholar]
49.Fagon JY, Chastre J, Trouillet JL, et al. Characterization of distal bronchial microflora during acute exacerbation of chronic bronchitis. Use of the protected specimen brush technique in 54 mechanically ventilated patients. Am Rev Respir Dis. 1990;142:1004–8. doi: 10.1164/ajrccm/142.5.1004. [DOI] [PubMed] [Google Scholar]
50.Soler N, Torres A, Ewig S, et al. Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. Am J Respir Crit Care Med. 1998;157:1498–1505. doi: 10.1164/ajrccm.157.5.9711044. [DOI] [PubMed] [Google Scholar]
51.Pela R, Marchesani F, Agostinelli C, et al. Airways microbial flora in COPD patients in stable clinical conditions and during exacerbations: A bronchoscopic investigation. Monaldi Arch Chest Dis. 1998;53:262–7. [PubMed] [Google Scholar]
52.Zalacain R, Sobradillo V, Amilibia J, et al. Predisposing factors to bacterial colonization in chronic obstructive pulmonary disease. Eur Respir J. 1999;13:343–8. doi: 10.1034/j.1399-3003.1999.13b21.x. [DOI] [PubMed] [Google Scholar]
53.Bandi V, Apicella MA, Mason E, et al. Nontypeable Haemophilus influenzae in the lower respiratory tract of patients with chronic bronchitis. Am J Respir Crit Care Med. 2001;164:2114–9. doi: 10.1164/ajrccm.164.11.2104093. [DOI] [PubMed] [Google Scholar]
54.Groeneveld K, Eijk PP, van Alphen L, Jansen HM, Zanen HC. Haemophilus influenzae infections in patients with chronic obstructive pulmonary disease despite specific antibodies in serum and sputum. Am Rev Respir Dis. 1990;141:1316–21. doi: 10.1164/ajrccm/141.5_Pt_1.1316. [DOI] [PubMed] [Google Scholar]
55.Yi K, Sethi S, Murphy TF. Human immune response to nontypable Haemophilus influenzae in chronic bronchitis. J Infect Dis. 1997;176:1247–52. doi: 10.1086/514119. [DOI] [PubMed] [Google Scholar]
56.Patel IS, Seemungal TAR, Wilks M, Lloyd-Owen SJ, Donaldson GC, Wedzicha JA. Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations. Thorax. 2002;57:759–64. doi: 10.1136/thorax.57.9.759. [DOI] [PMC free article] [PubMed] [Google Scholar]
57.Wilkinson TMA, Patel IS, Wilks M, Donaldson GC, Wedzicha JA. Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2003;167:1090–5. doi: 10.1164/rccm.200210-1179OC. [DOI] [PubMed] [Google Scholar]
58.Sethi S, Evans N, Grant BJB, Murphy TF. New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med. 2002;347:465–71. doi: 10.1056/NEJMoa012561. [DOI] [PubMed] [Google Scholar]
59.Stockley RA, O’Brien C, Pye A, Hill SL. Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD. Chest. 2000;117:1638–45. doi: 10.1378/chest.117.6.1638. [DOI] [PubMed] [Google Scholar]
60.Aaron SD, Angel JB, Lunua M, et al. Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;163:349–55. doi: 10.1164/ajrccm.163.2.2003122. [DOI] [PubMed] [Google Scholar]
61.Saetta M, Di Stefano A, Maestrelli P, et al. Airway eosinophilia in chronic bronchitis during exacerbations. Am J Respir Crit Care Med. 1994;150:1646–52. doi: 10.1164/ajrccm.150.6.7952628. [DOI] [PubMed] [Google Scholar]
62.Balbi B, Bason C, Balleari E, et al. Increased bronchoalveolar granulocytes and granulocyte/macrophage colony-stimulating factor during exacerbations of chronic bronchitis. Eur Respir J. 1997;10:846–50. [PubMed] [Google Scholar]
63.Bhowmik A, Seemungal TAR, Sapsford RJ, Wedzicha JA. Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax. 2000;55:114–20. doi: 10.1136/thorax.55.2.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
64.Gompertz S, O’Brien C, Bayley DL, Hill SL, Stockley RA. Changes in bronchial inflammation during acute exacerbations of chronic bronchitis. Eur Respir J. 2001;17:1112–9. doi: 10.1183/09031936.01.99114901. [DOI] [PubMed] [Google Scholar]
65.Hill AT, Campbell EJ, Hill SL, Bayley DL, Stockley RA. Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis. Am J Med. 2000;109:288–95. doi: 10.1016/S0002-9343(00)00507-6. [DOI] [PubMed] [Google Scholar]
66.Soler N, Ewig S, Torres A, Filella X, Gonzalez J, Zaubet A. Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease. Eur Respir J. 1999;14:1015–22. doi: 10.1183/09031936.99.14510159. [DOI] [PubMed] [Google Scholar]
67.Bresser P, Out TA, van Alphen L, Jansen HM, Lutter R. Airway inflammation in nonobstructive and obstructive chronic bronchitis with chronic Haemophilus influenzae airway infection. Comparison with noninfected patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;162:947–52. doi: 10.1164/ajrccm.162.3.9908103. [DOI] [PubMed] [Google Scholar]
68.Sethi S, Muscarella K, Evans N, Klingman KL, Grant BJB, Murphy TF. Airway inflammation and etiology of acute exacerbations of chronic bronchitis. Chest. 2000;118:1557–65. doi: 10.1378/chest.118.6.1557. [DOI] [PubMed] [Google Scholar]
69.Bresser P, van Alphen L, Habets F J, et al. Persisting Haemophilus influenzae strains induce, lower levels of interleukin-6 and interleukin-8 in H292 lung epithelial cells than nonpersisting strains. Eur Respir J. 1997;10:2319–26. doi: 10.1183/09031936.97.10102319. [DOI] [PubMed] [Google Scholar]
70.Hill AT, Campbell EJ, Bayley DL, Hill SL, Stockley RA. Evidence for excessive bronchial inflammation during an acute exacerbation of chronic obstructive pulmonary disease in patients with α1-antitrypsin deficiency (PiZ) Am J Respir Crit Care Med. 1999;160:1968–75. doi: 10.1164/ajrccm.160.6.9904097. [DOI] [PubMed] [Google Scholar]
71.Miravitlles M, Espinosa C, Fernandez-Laso E, Study Group of Bacterial Infection in COPD et al. Relationship between bacterial flora in sputum and functional impairment in patients with acute exacerbations of COPD. Chest. 1999;116:40–6. doi: 10.1378/chest.116.1.40. [DOI] [PubMed] [Google Scholar]
72.Eller J, Ede A, Schaberg T, Niederman M, Mauch H, Lode H. Infective exacerbations of chronic obstructive pulmonary disease. Relation between bacteriologic etiology and lung function. Chest. 1998;113:1542–8. doi: 10.1378/chest.113.6.1542. [DOI] [PubMed] [Google Scholar]
73.O’Brien C, Guest PJ, Hill SL, Stockley RA. Physiological and radiological characterisation of patients diagnosed with chronic obstructive pulmonary disease in primary care. Thorax. 2000;55:635–42. doi: 10.1136/thorax.55.8.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
74.Blasi F, Damato S, Cosentini R, Group Chlamydia InterAction with COPD (CIAC) Study et al. Chlamydia pneumoniae and chronic bronchitis: Association with severity and bacterial clearance following treatment. Thorax. 2002;57:672–6. doi: 10.1136/thorax.57.8.672. [DOI] [PMC free article] [PubMed] [Google Scholar]
75.Lieberman D, Ben-Yaakov M, Lazarovich Z, Ohana B, Boldur I. Chlamydia pneumoniae infection in acute exacerbations of chronic obstructive pulmonary disease: Analysis of 250 hospitalizations. Eur J Clin Microbiol Infect Dis. 2001;20:698–704. doi: 10.1007/s100960100596. [DOI] [PubMed] [Google Scholar]
76.Karnak D, Beng-sun S, Beder S, Kayacan O. Chlamydia pneumoniae infection and acute exacerbation of chronic obstructive pulmonary disease (COPD) Respir Med. 2001;95:811–6. doi: 10.1053/rmed.2001.1159. [DOI] [PubMed] [Google Scholar]
77.Mogulkoc N, Karakurt S, Isalska B, et al. Acute purulent exacerbation of chronic obstructive pulmonary disease and Chlamydia pneumoniae infection. Am J Respir Crit Care Med. 1999;160:349–53. doi: 10.1164/ajrccm.160.1.9809041. [DOI] [PubMed] [Google Scholar]
78.Wedzicha JA. Exacerbations. Etiology and pathophysiologic mechanisms. Chest. 2002;121:136S–41S. doi: 10.1378/chest.121.5_suppl.136S. [DOI] [PMC free article] [PubMed] [Google Scholar]
79.Seemungal T, Harper-Owen R, Bhowmik A, et al. Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;164:1618–23. doi: 10.1164/ajrccm.164.9.2105011. [DOI] [PubMed] [Google Scholar]
80.Seemungal TA, Harper-Owen R, Bhowmik A, Jeffries DJ, Wedzicha JA. Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease. Eur Respir J. 2000;16:677–83. doi: 10.1034/j.1399-3003.2000.16d19.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
81.Seemungal TA, Wedzicha JA. Viral infections in obstructive airway disease. Curr Opin Pulm Med. 2003;9:111–6. doi: 10.1097/00063198-200303000-00004. [DOI] [PubMed] [Google Scholar]
82.American Thoracic Society Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1995;152:S77–S120. [PubMed] [Google Scholar]
83.Sohy C, Pilette C, Niederman MS, Sibile Y. Acute exacerbation of chronic obstructive pulmonary disease and antibiotics: what studies are still-needed? Eur Respir J. 2002;19:966–75. doi: 10.1183/09031936.02.00291302. [DOI] [PubMed] [Google Scholar]
84.Rodrigues-Roisin R. Toward a consensus definition for COPD exacerbations. Chest. 2000;117:398S–401S. doi: 10.1378/chest.117.5_suppl_2.398S. [DOI] [PubMed] [Google Scholar]
85.Seemungal TAR, Donaldson GC, Bhowmik A, Jeffries DJ, Wedzicha JA. Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;161:1608–13. doi: 10.1164/ajrccm.161.5.9908022. [DOI] [PubMed] [Google Scholar]
86.Emerman CL, Cydulka RK. Evaluation of high-yield criteria for chest radiography in acute exacerbation of chronic obstructive pulmonary disease. Ann Emerg Med. 1993;22:780–4. doi: 10.1016/s0196-0644(05)81847-5. [DOI] [PubMed] [Google Scholar]
87.Sherman S, Skoney JA, Ravikrishnan KP. Routine chest radiographs in exacerbations of chronic obstructive pulmonary disease. Diagnostic value. Arch Intern Med. 1989;149:2493–6. doi: 10.1001/archinte.149.11.2493. [DOI] [PubMed] [Google Scholar]
88.Tsai TW, Gallagher EJ, Lombardi G, Gennis P, Carter W. Guidelines for the selective ordering of admission chest radiography in adult obstructive airway disease. Ann Emerg Med. 1993;22:1854–8. doi: 10.1016/S0196-0644(05)80992-8. [DOI] [PubMed] [Google Scholar]
89.Bach PB, Brown C, Gelfand SE, McCroy DC. Management of acute exacerbations of chronic obstructive pulmonary disease: A summary and appraisal of published evidence. Ann Intern Med. 2001;134:600–20. doi: 10.7326/0003-4819-134-7-200104030-00016. [DOI] [PubMed] [Google Scholar]
90.Snow V, Lascher S, Mottur-Pielson C. Evidence base for management of acute exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 2001;134:595–9. doi: 10.7326/0003-4819-134-7-200104030-00015. [DOI] [PubMed] [Google Scholar]
91.Saint S, Bent S, Vittinghoff E, Grady D. Antibiotics in chronic obstructive pulmonary disease exacerbations. A metaanalysis. JAMA. 1995;273:957–60. doi: 10.1001/jama.273.12.957. [DOI] [PubMed] [Google Scholar]
92.Nouira S, Marghli S, Belghith M, Besbes L, Elatrous S, Abrough F. Once daily oral ofloxacin in chronic obstructive pulmonary disease exacerbation, requiring mechanical ventilation: A randomised placebo-controlled trial. Lancet. 2001;358:2020–5. doi: 10.1016/S0140-6736(01)07097-0. [DOI] [PubMed] [Google Scholar]
93.Allegra L, Blasi F, de Bernardi B, Cosentini R, Tarsia P. Antibiotic treatment and baseline severity or disease in acute exacerbations of chronic bronchitis: A re-evaluation of previously published data of a placebo-controlled randomized study. Pulm Pharmaco Therapeut. 2001;14:149–55. doi: 10.1006/pupt.2001.0289. [DOI] [PubMed] [Google Scholar]
94.Anthonisen N, Manfreda J, Warren C, Hersfield E, Harding G, Nelson N. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Int Med. 1987;106:196–204. doi: 10.7326/0003-4819-106-2-196. [DOI] [PubMed] [Google Scholar]
95.Adams SG, Melo J, Luther M, Anzueto A. Antibiotics are associated with lower relapse rates in outpatients with acute exacerbations of COPD. Chest. 2000;117:1345–52. doi: 10.1378/chest.117.5.1345. [DOI] [PubMed] [Google Scholar]
96.Niroumand M, Grossman R. Airway infection. Infect Dis Clin N Am. 1998;12:671–88. doi: 10.1016/S0891-5520(05)70204-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
97.Miravitlles M, Murio C., Guerrero T. Factors associated with relapse after ambulatory treatment of acute exacerbations of chronic bronchitis. DAFNE Study Group. Eur Respir J. 2001;17:928–33. doi: 10.1183/09031936.01.17509280. [DOI] [PubMed] [Google Scholar]
98.Seemungal TAR, Donaldson GC, Paul EA, Bestall JC, Jeffries DJ, Wedzicha JA. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157:1418–22. doi: 10.1164/ajrccm.157.5.9709032. [DOI] [PubMed] [Google Scholar]
99.Saint S, Flaherty KR, Abrahamse P, Martinez FJ, Fendrick AM. Acute exacerbations of chronic bronchitis: Disease-specific issues that influence the cost-effectiveness of antimicrobial therapy. Clin Ther. 2001;23:499–512. doi: 10.1016/S0149-2918(01)80053-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
100.Ball P, Harris J, Lowson D, Tillotson G, Wilson R. Acute infective exacerbations of chronic bronchitis. Q J Med. 1995;88:61–8. [PubMed] [Google Scholar]
101.Sethi S. Etiology and management of infection in chronic obstructive pulmonary disease. Clin Pulm Med. 1999;6:327–32. [Google Scholar]
102.Anzueto AR. Risk stratification in acute exacerbations of chronic bronchitis: When and how to treat. Consultant. 2002;41(Suppl 12):S5–12. [Google Scholar]
103.Flaherty KR, Saint S, Fendrick AM, Martinez FJ. The spectrum of acute bronchitis: Using baseline factors to guide empirical therapy. Postgrad Med. 2001;109:39–47. doi: 10.3810/pgm.2001.02.859. [DOI] [PubMed] [Google Scholar]
104.Niederman MS. Antimicrobial therapy for acute exacerbations of chronic bronchitis: A critical path and consensus. Consultant. 2002;42(Suppl 12):S39–44. [Google Scholar]
105.Dewan NA, Rafique S, Kanwar B, et al. Acute exacerbation of COPD: Factors associated with poor treatment outcome. Chest. 2000;117:662–71. doi: 10.1378/chest.117.3.662. [DOI] [PubMed] [Google Scholar]
106.Shah PM, Maesen FPV, Domann A, Vetter N, Fiss E, Wesch R. Levofloxacin versus cefuroxime axetil in the treatment of acute exacerbation of chronic bronchitis: Results of a randomized, double-blind study. J Antimicrob Chemother. 1999;43:529–39. doi: 10.1093/jac/43.4.529. [DOI] [PubMed] [Google Scholar]
107.Wilson R, Kubin R, Ballin I, et al. Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis. J Antimicrob Chemother. 1999;44:501–13. doi: 10.1093/jac/44.4.501. [DOI] [PubMed] [Google Scholar]
108.Martinez FJ. The impact of antimicrobial selection on AECB: Resistance patterns of common respiratory pathogens. Consultant. 2002;42(Suppl 12):S33–8. [Google Scholar]
109.Doern GV. Antimicrobial use and the emergency of antimicrobial resistance with Streptococcus pneumoniae in the United States. Clin Inf Dis. 2001;33(Suppl 3):S187–92. doi: 10.1086/321847. [DOI] [PubMed] [Google Scholar]
110.Seaton RA, Steinke DT, Phillips G, MacDonald T, Davey PG. Community antibiotic therapy, hospitialization and subsequent respiratory tract isolation of Haemophilus influenzae resistance to amoxycillin: A nested case-control study. J Antimicrob Chemother. 2000;46:307–9. doi: 10.1093/jac/46.2.307. [DOI] [PubMed] [Google Scholar]
111.Thornsberry C, Sahm DF, Kelly LJ, et al. Regional trends in antimicrobial resistance among clinical isolates of Streptococcus pneumomiae, Haemophilus influenzae, and Moraxella catarrhalis in the United States: Results from the TRUST surveillance program, 1999–2000. Clin Inf Dis. 2002;34(Suppl 1):S4–S16. doi: 10.1086/324525. [DOI] [PubMed] [Google Scholar]
112.Lynch JP, III, Martinez FJ. Clinical relevance of macrolide-resistant Streptococcus pneumoniae for community acquired pneumonia. Clin Inf Dis. 2002;34(Suppl 1):S27–46. doi: 10.1086/324527. [DOI] [PubMed] [Google Scholar]
113.Hyde TB, Gay K, Stephens DS, et al. Macrolide resistance among invasive Streptococcus pneumoniae isolates. JAMA. 2001;285:1857–62. doi: 10.1001/jama.286.15.1857. [DOI] [PubMed] [Google Scholar]
114.Blondeau JM. A review or the comparative in-vitro activities of 12 antimicrobial agents, with a focus on five new ‘respiratory quinolones’. J Antimicrob Chemother. 1999;43(Suppl B):1–11. doi: 10.1093/jac/43.suppl_2.1. [DOI] [PubMed] [Google Scholar]
115.Thomson KS, Chartrand SA, Sanders CC, Block SL. In-vitro activity of levofloxacin against Streptococcus pneumoniae with various levels of penicillin resistance. J Antimicrob Chemother. 1999;43(Suppl C):15–9. doi: 10.1093/jac/43.suppl_3.15. [DOI] [PubMed] [Google Scholar]
116.Ho PL, Yung RWH, Tsang DNC, et al. Increasing resistance of Streptococcus pneumoniae to fluoroquinolones: Results of a Hong Kong multicenter study in 2000. J Antimicrob Chemother. 2001;48:659–65. doi: 10.1093/jac/48.5.659. [DOI] [PubMed] [Google Scholar]
117.Chen DK, McGeer A, De Azavedo JC, Low DE. Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. N Engl J Med. 1999;341:233–9. doi: 10.1056/NEJM199907223410403. [DOI] [PubMed] [Google Scholar]
118.Brueggemann AB, Coffman SL, Rhomberg P, et al. Fluoquinolone resistance in Streptococcus pneumoniae in United States since 1994–1995. Antimicrob Agent Chemother. 2002;46:680–8. doi: 10.1128/AAC.46.3.680-688.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
119.Daily P, Gelling L, Rothrock G, et al. Resistance of Streptococcus pneumoniae to fluoroquinolones—United States, 1995–1999. MMWR Morb Mortal Wkly Rep. 2001;50:800–4. [PubMed] [Google Scholar]
120.Ho PL, Tse WS, Tsang KWT, et al. Risk factors for acquisition of levofloxacin-resistance Streptococcus pneumoniae: A case-control study. Clin Inf Dis. 2001;32:701–7. doi: 10.1086/319222. [DOI] [PubMed] [Google Scholar]
121.Doern GV, Jones RN, Pfaller MA, Kugler K. The SENTRY Participants Group. Haemophilus influenzae and Moraxella catarrhalis from patients with community-acquired respiratory tract infections: Antimicrobial susceptibility patterns from the SENTRY antimicrobial surveillance program (United States and Canada, 1997) J Antimicrob Chemother. Antimicrob Agent Chemother. 1999;43:385–9. doi: 10.1128/aac.43.2.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
122.Richter SS, Brueggemann AB, Huynh HK, et al. A 1997–1998 national surveillance study: Moraxella catarrhalis and Haemophilus influenzae antimicrobial resistance in 34 US insitutions. Int J Antimicrob Agent. 1999;13:99–107. doi: 10.1016/S0924-8579(99)00112-0. [DOI] [PubMed] [Google Scholar]
123.Zhanel GG, Karlowsky JA, Low DE, Hoban DJ. Antibiotic resistance in respiratory tract isolates of Haemophilus influenzae and Moraxella catarrhalis collected from across Canada in 1997–1998. J Antimicrob Chemother. 2000;45:655–62. doi: 10.1093/jac/45.5.655. [DOI] [PubMed] [Google Scholar]
124.Murphy TF, Sethi S, Klingman KL, Brueggemann AB, Doern GV. Simultaneous respiratory tract colonization by multiple strains of nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease: Implications for antibiotic therapy. J Infect Dis. 1999;180:404–9. doi: 10.1086/314870. [DOI] [PubMed] [Google Scholar]
125.Verduin CM, Hol C, Fleer A, van Belkum A. Moraxella catarrhalis: From emerging to established pathogen. Clin Microbial Rev. 2002;15:125–44. doi: 10.1128/CMR.15.1.125-144.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
126.Pechere JC, Lacey L. Optimizing economic outcomes in antibiotic therapy of patients with acute bacterial exacerbations of chronic bronchitis. J Antimicrob Chemother. 2000;45:19–24. doi: 10.1093/jac/45.suppl_2.19. [DOI] [PubMed] [Google Scholar]
127.Madaras-Kelly KJ, Magdanz SB, Johnson CK, Jue SG. Clinical outcomes of ambulatory acute exacerbations of chronic bronchitis with older versus newer antimicrobials. Ann Pharmacother. 2002;36:975–80. doi: 10.1345/aph.1A315. [DOI] [PubMed] [Google Scholar]
128.Wilson R, Schentag JJ, Ball P, Mandell L. A comparison of gemifloxacin and clarithromycin in acute exacerbations of chronic bronchitis and long-term clinical outcomes. Clin Ther. 2002;24:639–52. doi: 10.1016/S0149-2918(02)85139-6. [DOI] [PubMed] [Google Scholar]
129.Weiss K, Restieri C, Gauthier R, et al. A nosocomial outbreak of fluoroquinolone-resistant Streptococcus pneumoniae. Clin Inf Dis. 2001;33:517–22. doi: 10.1086/322658. [DOI] [PubMed] [Google Scholar]
130.DeAbate CA, Russell M, McElvaine P, et al. Safety and efficacy of oral levofloxacin versus cefuroxime axetil in acute bacterial exacerbation of chronic bronchitis. Respir Care. 1997;42:206–13. [Google Scholar]
131.Habib MP, Gentry LO, Rodriguez-Gomez G, et al. Multicenter, randomized study comparing efficacy and safety of oral levofloxacin and cefaclor in treatment of acute bacterial exacerbations of chronic bronchitis. Infect Dis Clin Pract. 1998;7:101–9. doi: 10.1097/00019048-199802000-00009. [DOI] [Google Scholar]
132.Anzuelo A, Niederman MS, Tillotson GS, Bronchitis Study Group Etiology, susceptibility, and treatment of acute bacterial exacerbations of complicated chronic bronchitis in the primary care setting: Ciprofloxacin 750 mg bid versus clarithromycin 500 mg bid. Clin Ther. 1998;20:835–50. doi: 10.1016/s0149-2918(98)80071-4. [DOI] [PubMed] [Google Scholar]
133.Chodosh S, Schreurs A, Siami G, Group Bronchitis Study et al. Efficacy of oral ciprofloxacin vs clarithromycin for treatment of acute bacterial exacerbations of chronic bronchitis. Clin Inf Dis. 1998;27:730–8. doi: 10.1086/514934. [DOI] [PubMed] [Google Scholar]
134.Grossman R, Mukherjee J, Vaughan D, et al. A 1-year community-based health economic study of ciprofloxacin vs usual antibiotic treatment in acute exacerbations of chronic bronchitis. The Canadian Ciprofloxacin Health Economic Study Group. Chest. 1998;113:131–41. doi: 10.1378/chest.113.1.131. [DOI] [PubMed] [Google Scholar]
135.Torrance G, Walker V, Grossman R, et al. Economic evaluation of ciprofloxacin compared with usual antibacterial care for the treatment of acute exacerbations of chronic bronchitis in patients followed for 1 year. Pharmacoeconomics. 1999;16:499–520. doi: 10.2165/00019053-199916050-00007. [DOI] [PubMed] [Google Scholar]
136.Destache CJ, Dewan N, O’Donohue WJ, Campbell JC, Angelillo VA. Clinical and economic considerations in the treatment of acute exacerbations of chronic bronchitis. J Antimicrob Chemother. 1999;43(Suppl A):107–113. doi: 10.1093/jac/43.suppl_1.107. [DOI] [PubMed] [Google Scholar]
137.Stoller JK. Acute exacerbations of chronic obstructive pulmonary disease. N Engl J Med. 2002;346:988–94. doi: 10.1056/NEJMcp012477. [DOI] [PubMed] [Google Scholar]
138.McCroy DC, Brown C, Gelfand SE, Bach PB. Management of exacerbations of COPD: A summary and appraisal of the published evidence. Chest. 2001;119:1190–209. doi: 10.1378/chest.119.4.1190. [DOI] [PubMed] [Google Scholar]
139.Singh JM, Palda VA, Stanbrook MB, Chapman KR. Corticosteroid therapy for patients with acute exacerbations of chronic obstructive pulmonary disease. A systematic review. Arch Intern Med. 2002;162:2527–36. doi: 10.1001/archinte.162.22.2527. [DOI] [PubMed] [Google Scholar]
140.Niewoehner DE, Erbland ML, Deupree RH, Department of Veterans Affairs Cooperative Study Group et al. Effect of systemic glucocorticoids on exacerbationsis of chronic obstructive pulmonary disease. N Engl J Med. 1999;340:1941–7. doi: 10.1056/NEJM199906243402502. [DOI] [PubMed] [Google Scholar]
141.Sayner A, Aytemur AZ, Cirit M, Unsal I. Systemic glucocorticoids in severe exacerbations of COPD. Chest. 2001;119:726–30. doi: 10.1378/chest.119.3.726. [DOI] [PubMed] [Google Scholar]
142.Davies L, Nisar M, Pearson MG, Costello RW, Earis JE, Calverley PMA. Oral corticosteroid trials in the management of stable chronic obstructive pulmonary disease. Q J Med. 1999;92:395–400. doi: 10.1093/qjmed/92.7.395. [DOI] [PubMed] [Google Scholar]
143.Maltais F, Ostinelli J, Bourbeau J, et al. Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: A randomized controlled trial. Am J Respir Crit Care Med. 2002;165:698–703. doi: 10.1164/ajrccm.165.5.2109093. [DOI] [PubMed] [Google Scholar]
144.Sethi S. Infectious exacerbations of chronic bronchitis: diagnosis and management. J Antimicrob Chemother. 1999;43(Suppl A):97–105. doi: 10.1093/jac/43.suppl_1.97. [DOI] [PubMed] [Google Scholar]
145.Dere WH. Acute bronchitis: Results of U.S. and European trials of antibiotic therapy. Am J Med. 1992;92(Suppl 6A):53S–7S. doi: 10.1016/0002-9343(92)90608-E. [DOI] [PMC free article] [PubMed] [Google Scholar]
146.Jonsson JS, Sigurdsson JA, Kristinsson KG, Guthnadottir M, Magnusson S. Acute bronchitis in adults. How close do we come to its aetiology in general practice? Scand J Prim Health Care. 1997;15:156–60. doi: 10.3109/02813439709018507. [DOI] [PubMed] [Google Scholar]
147.Ball P. Epidemiology and treatment of chronic bronchitis and its exacerbations. Chest. 1995;108:43S–52S. doi: 10.1378/chest.108.2_Supplement.43S. [DOI] [PMC free article] [PubMed] [Google Scholar]
148.Gwaltney JM., Jr. Acute bronchitis. In: Mandell G., Bennett J., Dolin R., editors. Mandell: Principles and Practice of Infectious Disease. 5th ed. Philadelphia: Churchill Livingstone; 2000. pp. 703–6. [Google Scholar]
149.Kaiser L, Lew D, Hirschel B, et al. Effects of antibiotic, treatment in the subset of common-cold patients who have bacteria in nasopharyngeal secretions. Lancet. 1996;347:1507–10. doi: 10.1016/S0140-6736(96)90670-4. [DOI] [PubMed] [Google Scholar]
150.Falck G, Heyman L, Gnarpe J, Gnarpe H. Chlamydia Pneumoniae (TWAR): A common agent in acute bronchitis. Scand J Infect Dis. 1994;26:179–87. doi: 10.3109/00365549409011782. [DOI] [PubMed] [Google Scholar]
151.Buscho RO, Saxtan D, Shultz PS, Finch E, Mufson MA. Infections with viruses and Mycoplasma pneumoniae during exacerbations of chronic bronchitis. J Infect Dis. 1978;137:377–83. doi: 10.1093/infdis/137.4.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
152.Smith CB, Goldern CA, Kanner RE, Renzetti AD. Association of viral and Mycoplasma pneumoniae infections with acute respiratory illness in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1980;121:225–32. doi: 10.1164/arrd.1980.121.2.225. [DOI] [PubMed] [Google Scholar]
153.Herwaldt LA. Pertussis in adults: What physicians need to know. Arch Intern Med. 1991;151:1510–2. doi: 10.1001/archinte.151.8.1510. [DOI] [PubMed] [Google Scholar]
154.Falsey AR, McCann RM, Hall WJ, et al. The “common cold” in frail older persons: Impact of rhinovirus and coronavirus in a senior daycare center. JAGS. 1997;45:706–11. doi: 10.1111/j.1532-5415.1997.tb01474.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
155.Hendley JO, Fishburne HB, Swaltney JM. Coronavirus infections in working adults: Eight-year study with 229 E and OC 43. Am Rev Respir Dis. 1972;105:805–11. doi: 10.1164/arrd.1972.105.5.805. [DOI] [PubMed] [Google Scholar]
156.Greenberg SB, Allen M, Wilson J, Atmar RL. Respiratory viral infections in adults with and without chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;162:167–73. doi: 10.1164/ajrccm.162.1.9911019. [DOI] [PubMed] [Google Scholar]
157.Rhode G, Wiethege A, Borg I, et al. Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: A case-control study. Thorax. 2003;58:37–42. doi: 10.1136/thorax.58.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
158.Seemungal TA, Wedzicha JA, MacCallum PK, Johnston SL, Lambert PA. Chlamydia pneumoniae and COPD exacerbation. Thorax. 2002;57:1087–8. doi: 10.1136/thorax.57.12.1087-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
159.Fahey T, Stocks N, Thomas T. Quantitative systematic review of randomised controlled trials comparing antibiotic with placebo for acute cough in adults. BMJ. 1998;316:906–10. doi: 10.1136/bmj.316.7135.906. [DOI] [PMC free article] [PubMed] [Google Scholar]
160.Smucny JJ, Becker LA, Glazier RH, McIsaac W. Are antibiotics effective treatment for acute bronchitis? A meta-analysis. J Fam Pract. 1998;47:453–60. [PubMed] [Google Scholar]
161.Bent S, Saint S, Vittinghoff E, Grady D. Antibiotics in acute bronchitis: A metal-analysis. Am J Med. 1999;07:62–7. doi: 10.1016/S0002-9343(99)00167-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
162.Evans AT, Husain S, Durairaj L, Sadowski LS, Charles-Damte M, Wang Y. Azithromycin for acute bronchitis: A randomised, double-blind, controlled trial. Lancet. 2002;359:1648–54. doi: 10.1016/S0140-6736(02)08597-5. [DOI] [PubMed] [Google Scholar]
163.Lode H. Respiratory tract infections: When is antibiotic therapy indicated? Clin Ther. 1991;13:149–56. [PubMed] [Google Scholar]
164.Hueston W J. Albuterol delivered by metered-dose inhaler to treat acute bronchitis. J Fam Pract. 1994;39. [PubMed]
165.Grossman R. Guidelines for the treatment of acute exacerbations of chronic bronchitis. Chest. 1997;112(Suppl 6):311S–3S. doi: 10.1378/chest.112.6_supplement.310s. [DOI] [PubMed] [Google Scholar]
166.Wilson R. Outcome predictors in bronchitis. Chest. 1995;106(Suppl):53S–57S. doi: 10.1378/chest.108.2_supplement.53s. [DOI] [PubMed] [Google Scholar]
167.Adams SG, Anzueto A. Antibiotic therapy in acute exacerbations of chronic bronchitis: Part 1. The rationale. Pulm Perspect. 2002;19:6–8. [Google Scholar]
168.Adams SG, Anzueto A. Antibiotic therapy in acute exacerbations of chronic bronchitis: Part 2. Pul Perspect. 2002;19:1–5. doi: 10.1053/srin.2000.18077. [DOI] [PubMed] [Google Scholar]

[CR1] 1.Knutson D, Braun C. Diagnosis and management of acute bronchitis. Am Fam Phy. 2002;65:2039–44. [PubMed] [Google Scholar]

[CR2] 2.Gonzales R, Sande MA. Uncomplicated acute bronchitis. Ann Intern Med. 2000;133:981–91. doi: 10.7326/0003-4819-133-12-200012190-00014. [DOI] [PubMed] [Google Scholar]

[CR3] 3.Steinman MA, Landefeld CS, Gonzales R. Predictors of broad-spectrum antibiotic prescribing for acute respiratory tract infections in adult primary care. JAMA. 2003;289:719–25. doi: 10.1001/jama.289.6.719. [DOI] [PubMed] [Google Scholar]

[CR4] 4.Gonzales R, Steiner JF, Sande MA. Antibiotic prescribing for adults with colds, upper respiratory tract infections, and bronchitis by ambulatory care physicians. JAMA. 1997;278:901–4. doi: 10.1001/jama.278.11.901. [DOI] [PubMed] [Google Scholar]

[CR5] 5.Cantrell R, Young AF, Martin BC. Antibiotic prescribing in ambulatory care settings for adults with colds, upper respiratory tract infections, and bronchitis. Clin Ther. 2002;24:170–82. doi: 10.1016/S0149-2918(02)85013-5. [DOI] [PubMed] [Google Scholar]

[CR6] 6.Niederman MS, McCombs JS, Unger AN, Kumar A, Popovian R. Treatment cost of acute exacerbations of chronic bronchitis. Clin Therapeut. 1999;21:576–91. doi: 10.1016/S0149-2918(00)88310-1. [DOI] [PubMed] [Google Scholar]

[CR7] 7.Hall CB, Geiman JM, Biggar R, Kotok KI, Hogan PM, Douglas GR., Jr. Respiratory syncytial virus infection within families. N Engl J Med. 1976;294:414–9. doi: 10.1056/NEJM197602192940803. [DOI] [PubMed] [Google Scholar]

[CR8] 8.Falsey AR, Walsh EE. Respiratory syncytial virus infection in adults. Clin Microbiol Rev. 2000;13:371–84. doi: 10.1128/CMR.13.3.371-384.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR9] 9.Dowell SF, Anderson LJ, Gary HEJ, Erdman DD, Plouffe JF, File TM., Jr. Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults. J Infect Dis. 1996;174:456–62. doi: 10.1093/infdis/174.3.456. [DOI] [PubMed] [Google Scholar]

[CR10] 10.Falsey AR, Cunningham CK, Barker WH, et al. Respiratory syncytial virus and influenza A infections in the hospitalized elderly. J Infect Dis. 1995;172:389–94. doi: 10.1093/infdis/172.2.389. [DOI] [PubMed] [Google Scholar]

[CR11] 11.Monto AS, Gravenstein S, Elliott M, Colopy M, Schweinle J. Clinical signs and symptoms predicting influenza infection. Arch Intern Med. 2000;160:3243–7. doi: 10.1001/archinte.160.21.3243. [DOI] [PubMed] [Google Scholar]

[CR12] 12.Macfarlane JT, Colville A, Guion A, Macfarlane RM, Rose EH. Prospective study of aetiology and outcome of adult lower-respiratory-tract infections in the community. Lancet. 1993;341:511–514. doi: 10.1016/0140-6736(93)90275-L. [DOI] [PubMed] [Google Scholar]

[CR13] 13.Macfarlane J, Holmes W, Gard P, et al. Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community. Thorax. 2001;56:109–14. doi: 10.1136/thorax.56.2.109. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR14] 14.Hament JM, Kimpen JLL, Fleer A, Wolfs TFW. Respiratory viral infection predisposing for bacterial disease: A concise review. FEMS Immunol Med Microbiol. 1999;26:189–95. doi: 10.1111/j.1574-695X.1999.tb01389.x. [DOI] [PubMed] [Google Scholar]

[CR15] 15.Hahn DL, Azenabor AA, Beatty WL, Byrne GI. Chlamydia pneumoniae as a respiratory pathogen. Front Biosci. 2002;7:66–76. doi: 10.2741/hahn. [DOI] [PubMed] [Google Scholar]

[CR16] 16.von Konig CHW, Halperin S, Riffelmann M, Guiso N. Pertussis of adults and infants. Lancet Inf Dis. 2002;2:744–50. doi: 10.1016/S1473-3099(02)00452-8. [DOI] [PubMed] [Google Scholar]

[CR17] 17.Anonymous. Resurgence of pertussis United States, 1993. MMWR Morb Mortal Wkly Rep. 1993;42:952-3/959-60. [PubMed]

[CR18] 18.Metlay JP, Kapoor WN, Fine JM. Does this patient have community-acquired pneumonia? diagnosing pneumonia by history and physical examination. JAMA. 1997;278:1440–5. doi: 10.1001/jama.278.17.1440. [DOI] [PubMed] [Google Scholar]

[CR19] 19.Metlay JP, Fine MJ. Testing strategies in the initial management of patients with community-acquired pneumonia. Ann Intern Med. 2003;138:109–18. doi: 10.7326/0003-4819-138-2-200301210-00012. [DOI] [PubMed] [Google Scholar]

[CR20] 20.Ruiz M, Arosio C, Salman P, Bauer TT, Torres A. Diagnosis of pneumonia and monitoring of infection eradication. Drugs. 2000;60:1289–302. doi: 10.2165/00003495-200060060-00004. [DOI] [PubMed] [Google Scholar]

[CR21] 21.McFadden JP, Price RC, Eastwood HD, Briggs RS. Raised respiratory rate in elderly patients: A valuable physical sign. Br Med J. 1982;284:626–7. doi: 10.1136/bmj.284.6316.626. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR22] 22.Metlay JP, Schulz R, Li YH, et al. Influence of age on symptoms at presentation in patients with community-acquired pneumonia. Arch Intern Med. 1997;157:1453–9. doi: 10.1001/archinte.157.13.1453. [DOI] [PubMed] [Google Scholar]

[CR23] 23.Seppa Y, Bloigu A, Honkanen PO, Miettinen L, Syrjala H. Severity assessment of lower respiratory tract infection in elderly patients in primary care. Arch Intern Med. 2001;161:2709–13. doi: 10.1001/archinte.161.22.2709. [DOI] [PubMed] [Google Scholar]

[CR24] 24.Wipf JE, Lipsky BJ, Hirschmann JV, et al. Diagnosing pneumonia by physical examination. Relevant or relic? Arch Intern Med. 1999;59:1082–7. doi: 10.1001/archinte.159.10.1082. [DOI] [PubMed] [Google Scholar]

[CR25] 25.Dumyati G, Falsey AR. Antivirals for influenza. What is their role in the older patient? Drugs Aging. 2002;19:777–86. doi: 10.2165/00002512-200219100-00006. [DOI] [PubMed] [Google Scholar]

[CR26] 26.Bloivin G, Hardy I, Tellier G, Mazaide J. Predicting influenza infections during epidemics with use of a clinical case definition. Clin Inf Dis. 2003;31:1166–9. doi: 10.1086/317425. [DOI] [PubMed] [Google Scholar]

[CR27] 27.Walsh EE, Cox C, Falsey AR. Clinical features of influenza A virus infection in older hospitalized persons. J Am Geriatr Soc. 2002;50:1498–503. doi: 10.1046/j.1532-5415.2002.50404.x. [DOI] [PubMed] [Google Scholar]

[CR28] 28.Neuzil KM, O’Connor TZ, Gorse GJ, Nichol KL. Recognizing influenza in older patients with chronic obstructive pulmonary disease who have received influenza vaccine. Clin Inf Dis. 2003;36:169–74. doi: 10.1086/345668. [DOI] [PubMed] [Google Scholar]

[CR29] 29.Irwin RS, Boulet LP, Cloutier MM, et al. Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians. Chest. 1998;114:133S–81S. doi: 10.1378/chest.114.2_supplement.133s. [DOI] [PubMed] [Google Scholar]

[CR30] 30.Williamson HA., Jr. Pulmonary function tests in acute bronchitis: Evidence for reversible airflow obstruction. J Fam Pract. 1987;3:251–6. [PubMed] [Google Scholar]

[CR31] 31.Boldy DA, Skidmore SJ, Ayres JG. Acute bronchitis in the community: Clinical features, infective factors, changes in pulmonary function and bronchial reactivity to histamine. Respir Med. 1990;84:377–85. doi: 10.1016/S0954-6111(08)80072-8. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR32] 32.Jonsson JS, Gislason T, Gislason D, Sigurdsson JA. Acute bronchitis and clinical outcome three years later: Prospective cohort study. BMJ. 1998;317:1433–1433. doi: 10.1136/bmj.317.7170.1433. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR33] 33.Metlay JP, Stafford RS, Singer DE. National trends in the use of antibiotics by primary care physicians for adult patients with cough. Arch Intern Med. 1998;158:1813–8. doi: 10.1001/archinte.158.16.1813. [DOI] [PubMed] [Google Scholar]

[CR34] 34.Dosh SA, Hickner J, Mainous AG, III, Ebell MH. Predictors of antibiotic prescribing for nonspecific upper respiratory infections, acute bronchitis, and acute sinusitis: An UPRNet study. J Fam Pract. 2000;49:407–14. [PubMed] [Google Scholar]

[CR35] 35.Hueston WJ, Hopper JE, Dacus EN, Mainous AG., III Why are antibiotics prescribed for patients with acute bronchitis? A postintervention analysis. J Am Board Fam Pract. 2000;13:398–402. doi: 10.3122/15572625-13-6-398. [DOI] [PubMed] [Google Scholar]

[CR36] 36.Linder JA, Sim I. Antibiotic treatment of acute bronchitis in smokers. A systematic review. J Gen Intern Med. 2002;17:230–4. doi: 10.1046/j.1525-1497.2002.10405.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR37] 37.Gonzales R, Bartlett JG, Besser RE, et al. Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: Background. Ann Emerg Med. 2001;37:720–7. doi: 10.1067/mem.2001.em376720. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR38] 38.Macfarlane J, Holmes W, Gard P, Thornhill D, Macfarlane R, Hubbard R. Reducing antibiotic use for acute bronchitis in primary care: blinded randomised controlled trial of patient information leaflet. BMJ. 2002;324:1–6. doi: 10.1136/bmj.324.7329.91. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR39] 39.Gonzales R, Steiner JF, Lum A, Barrett PH., Jr. Decreasing antibiotic use in ambulatory practice. Impact of a multidimensional intervention on the treatment of uncomplicated acute bronchitis in adults. JAMA. 1999;281:1512–9. doi: 10.1001/jama.281.16.1512. [DOI] [PubMed] [Google Scholar]

[CR40] 40.Gonzales R, Steiner JF, Maselli J, Lum A, Barrett PH. Impact of reducing antibiotic prescribing for acute bronchitis on patient satisfaction. Eff Clin Pract. 2001;4:105–11. [PubMed] [Google Scholar]

[CR41] 41.Hueston WJ. A comparison of albuterol and erythromycin for the treatment of acute bronchitis. J Fam Pract. 1991;33:476–80. [PubMed] [Google Scholar]

[CR42] 42.Smucny JJ, Flynn CA, Becker LA, Glazier RH. Are β2-agonists effective treatment for acute bronchitis or acute cough in patients without underlying pulmonary disease? A systematic review. J Fam Pract. 2001;50:945–51. [PubMed] [Google Scholar]

[CR43] 43.Melbye H, Aasebo U, Straume B. Symptomatic effect of inhaled fenoterol in acute bronchitis: A placebo-controlled double-blind study. Fam Pract. 1991;8:216–22. doi: 10.1093/fampra/8.3.216. [DOI] [PubMed] [Google Scholar]

[CR44] 44.Sethi S, Murphy TF. Bacterial infection in chronic obstructive pulmonary disease in 2000: A state-of-the-art review. Clin Microbiol Rev. 2001;14:336–63. doi: 10.1128/CMR.14.2.336-363.2001. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR45] 45.White AJ, Gompertz S, Stockley RA. Chronic obstructive pulmonary disease 6: The etiology of exacerbations of chronic obstructive pulmonary disease. Thorax. 2003;58:73–80. doi: 10.1136/thorax.58.1.73. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR46] 46.Miravitlles M. Exacerbations of chronic obstructive pulmonary disease: When are bacteria important? Eur Respir J. 2002;20(Suppl 36):9S–19S. doi: 10.1183/09031936.02.00400302. [DOI] [PubMed] [Google Scholar]

[CR47] 47.Wilson R. Bacteria, antibiotics and COPD. Eur Respir J. 2001;17:995–1007. doi: 10.1183/09031936.01.17509950. [DOI] [PubMed] [Google Scholar]

[CR48] 48.Monso E, Ruiz J, Rosell A, et al. Bacterial infection in chronic obstructive pulmonary disease: A study of stable and exacerbated outpatients using the protected specimen brush. Am J Respir Crit Care Med. 1995;152:1316–20. doi: 10.1164/ajrccm.152.4.7551388. [DOI] [PubMed] [Google Scholar]

[CR49] 49.Fagon JY, Chastre J, Trouillet JL, et al. Characterization of distal bronchial microflora during acute exacerbation of chronic bronchitis. Use of the protected specimen brush technique in 54 mechanically ventilated patients. Am Rev Respir Dis. 1990;142:1004–8. doi: 10.1164/ajrccm/142.5.1004. [DOI] [PubMed] [Google Scholar]

[CR50] 50.Soler N, Torres A, Ewig S, et al. Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. Am J Respir Crit Care Med. 1998;157:1498–1505. doi: 10.1164/ajrccm.157.5.9711044. [DOI] [PubMed] [Google Scholar]

[CR51] 51.Pela R, Marchesani F, Agostinelli C, et al. Airways microbial flora in COPD patients in stable clinical conditions and during exacerbations: A bronchoscopic investigation. Monaldi Arch Chest Dis. 1998;53:262–7. [PubMed] [Google Scholar]

[CR52] 52.Zalacain R, Sobradillo V, Amilibia J, et al. Predisposing factors to bacterial colonization in chronic obstructive pulmonary disease. Eur Respir J. 1999;13:343–8. doi: 10.1034/j.1399-3003.1999.13b21.x. [DOI] [PubMed] [Google Scholar]

[CR53] 53.Bandi V, Apicella MA, Mason E, et al. Nontypeable Haemophilus influenzae in the lower respiratory tract of patients with chronic bronchitis. Am J Respir Crit Care Med. 2001;164:2114–9. doi: 10.1164/ajrccm.164.11.2104093. [DOI] [PubMed] [Google Scholar]

[CR54] 54.Groeneveld K, Eijk PP, van Alphen L, Jansen HM, Zanen HC. Haemophilus influenzae infections in patients with chronic obstructive pulmonary disease despite specific antibodies in serum and sputum. Am Rev Respir Dis. 1990;141:1316–21. doi: 10.1164/ajrccm/141.5_Pt_1.1316. [DOI] [PubMed] [Google Scholar]

[CR55] 55.Yi K, Sethi S, Murphy TF. Human immune response to nontypable Haemophilus influenzae in chronic bronchitis. J Infect Dis. 1997;176:1247–52. doi: 10.1086/514119. [DOI] [PubMed] [Google Scholar]

[CR56] 56.Patel IS, Seemungal TAR, Wilks M, Lloyd-Owen SJ, Donaldson GC, Wedzicha JA. Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations. Thorax. 2002;57:759–64. doi: 10.1136/thorax.57.9.759. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR57] 57.Wilkinson TMA, Patel IS, Wilks M, Donaldson GC, Wedzicha JA. Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2003;167:1090–5. doi: 10.1164/rccm.200210-1179OC. [DOI] [PubMed] [Google Scholar]

[CR58] 58.Sethi S, Evans N, Grant BJB, Murphy TF. New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med. 2002;347:465–71. doi: 10.1056/NEJMoa012561. [DOI] [PubMed] [Google Scholar]

[CR59] 59.Stockley RA, O’Brien C, Pye A, Hill SL. Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD. Chest. 2000;117:1638–45. doi: 10.1378/chest.117.6.1638. [DOI] [PubMed] [Google Scholar]

[CR60] 60.Aaron SD, Angel JB, Lunua M, et al. Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;163:349–55. doi: 10.1164/ajrccm.163.2.2003122. [DOI] [PubMed] [Google Scholar]

[CR61] 61.Saetta M, Di Stefano A, Maestrelli P, et al. Airway eosinophilia in chronic bronchitis during exacerbations. Am J Respir Crit Care Med. 1994;150:1646–52. doi: 10.1164/ajrccm.150.6.7952628. [DOI] [PubMed] [Google Scholar]

[CR62] 62.Balbi B, Bason C, Balleari E, et al. Increased bronchoalveolar granulocytes and granulocyte/macrophage colony-stimulating factor during exacerbations of chronic bronchitis. Eur Respir J. 1997;10:846–50. [PubMed] [Google Scholar]

[CR63] 63.Bhowmik A, Seemungal TAR, Sapsford RJ, Wedzicha JA. Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax. 2000;55:114–20. doi: 10.1136/thorax.55.2.114. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR64] 64.Gompertz S, O’Brien C, Bayley DL, Hill SL, Stockley RA. Changes in bronchial inflammation during acute exacerbations of chronic bronchitis. Eur Respir J. 2001;17:1112–9. doi: 10.1183/09031936.01.99114901. [DOI] [PubMed] [Google Scholar]

[CR65] 65.Hill AT, Campbell EJ, Hill SL, Bayley DL, Stockley RA. Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis. Am J Med. 2000;109:288–95. doi: 10.1016/S0002-9343(00)00507-6. [DOI] [PubMed] [Google Scholar]

[CR66] 66.Soler N, Ewig S, Torres A, Filella X, Gonzalez J, Zaubet A. Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease. Eur Respir J. 1999;14:1015–22. doi: 10.1183/09031936.99.14510159. [DOI] [PubMed] [Google Scholar]

[CR67] 67.Bresser P, Out TA, van Alphen L, Jansen HM, Lutter R. Airway inflammation in nonobstructive and obstructive chronic bronchitis with chronic Haemophilus influenzae airway infection. Comparison with noninfected patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;162:947–52. doi: 10.1164/ajrccm.162.3.9908103. [DOI] [PubMed] [Google Scholar]

[CR68] 68.Sethi S, Muscarella K, Evans N, Klingman KL, Grant BJB, Murphy TF. Airway inflammation and etiology of acute exacerbations of chronic bronchitis. Chest. 2000;118:1557–65. doi: 10.1378/chest.118.6.1557. [DOI] [PubMed] [Google Scholar]

[CR69] 69.Bresser P, van Alphen L, Habets F J, et al. Persisting Haemophilus influenzae strains induce, lower levels of interleukin-6 and interleukin-8 in H292 lung epithelial cells than nonpersisting strains. Eur Respir J. 1997;10:2319–26. doi: 10.1183/09031936.97.10102319. [DOI] [PubMed] [Google Scholar]

[CR70] 70.Hill AT, Campbell EJ, Bayley DL, Hill SL, Stockley RA. Evidence for excessive bronchial inflammation during an acute exacerbation of chronic obstructive pulmonary disease in patients with α1-antitrypsin deficiency (PiZ) Am J Respir Crit Care Med. 1999;160:1968–75. doi: 10.1164/ajrccm.160.6.9904097. [DOI] [PubMed] [Google Scholar]

[CR71] 71.Miravitlles M, Espinosa C, Fernandez-Laso E, Study Group of Bacterial Infection in COPD et al. Relationship between bacterial flora in sputum and functional impairment in patients with acute exacerbations of COPD. Chest. 1999;116:40–6. doi: 10.1378/chest.116.1.40. [DOI] [PubMed] [Google Scholar]

[CR72] 72.Eller J, Ede A, Schaberg T, Niederman M, Mauch H, Lode H. Infective exacerbations of chronic obstructive pulmonary disease. Relation between bacteriologic etiology and lung function. Chest. 1998;113:1542–8. doi: 10.1378/chest.113.6.1542. [DOI] [PubMed] [Google Scholar]

[CR73] 73.O’Brien C, Guest PJ, Hill SL, Stockley RA. Physiological and radiological characterisation of patients diagnosed with chronic obstructive pulmonary disease in primary care. Thorax. 2000;55:635–42. doi: 10.1136/thorax.55.8.635. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR74] 74.Blasi F, Damato S, Cosentini R, Group Chlamydia InterAction with COPD (CIAC) Study et al. Chlamydia pneumoniae and chronic bronchitis: Association with severity and bacterial clearance following treatment. Thorax. 2002;57:672–6. doi: 10.1136/thorax.57.8.672. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR75] 75.Lieberman D, Ben-Yaakov M, Lazarovich Z, Ohana B, Boldur I. Chlamydia pneumoniae infection in acute exacerbations of chronic obstructive pulmonary disease: Analysis of 250 hospitalizations. Eur J Clin Microbiol Infect Dis. 2001;20:698–704. doi: 10.1007/s100960100596. [DOI] [PubMed] [Google Scholar]

[CR76] 76.Karnak D, Beng-sun S, Beder S, Kayacan O. Chlamydia pneumoniae infection and acute exacerbation of chronic obstructive pulmonary disease (COPD) Respir Med. 2001;95:811–6. doi: 10.1053/rmed.2001.1159. [DOI] [PubMed] [Google Scholar]

[CR77] 77.Mogulkoc N, Karakurt S, Isalska B, et al. Acute purulent exacerbation of chronic obstructive pulmonary disease and Chlamydia pneumoniae infection. Am J Respir Crit Care Med. 1999;160:349–53. doi: 10.1164/ajrccm.160.1.9809041. [DOI] [PubMed] [Google Scholar]

[CR78] 78.Wedzicha JA. Exacerbations. Etiology and pathophysiologic mechanisms. Chest. 2002;121:136S–41S. doi: 10.1378/chest.121.5_suppl.136S. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR79] 79.Seemungal T, Harper-Owen R, Bhowmik A, et al. Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;164:1618–23. doi: 10.1164/ajrccm.164.9.2105011. [DOI] [PubMed] [Google Scholar]

[CR80] 80.Seemungal TA, Harper-Owen R, Bhowmik A, Jeffries DJ, Wedzicha JA. Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease. Eur Respir J. 2000;16:677–83. doi: 10.1034/j.1399-3003.2000.16d19.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR81] 81.Seemungal TA, Wedzicha JA. Viral infections in obstructive airway disease. Curr Opin Pulm Med. 2003;9:111–6. doi: 10.1097/00063198-200303000-00004. [DOI] [PubMed] [Google Scholar]

[CR82] 82.American Thoracic Society Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1995;152:S77–S120. [PubMed] [Google Scholar]

[CR83] 83.Sohy C, Pilette C, Niederman MS, Sibile Y. Acute exacerbation of chronic obstructive pulmonary disease and antibiotics: what studies are still-needed? Eur Respir J. 2002;19:966–75. doi: 10.1183/09031936.02.00291302. [DOI] [PubMed] [Google Scholar]

[CR84] 84.Rodrigues-Roisin R. Toward a consensus definition for COPD exacerbations. Chest. 2000;117:398S–401S. doi: 10.1378/chest.117.5_suppl_2.398S. [DOI] [PubMed] [Google Scholar]

[CR85] 85.Seemungal TAR, Donaldson GC, Bhowmik A, Jeffries DJ, Wedzicha JA. Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;161:1608–13. doi: 10.1164/ajrccm.161.5.9908022. [DOI] [PubMed] [Google Scholar]

[CR86] 86.Emerman CL, Cydulka RK. Evaluation of high-yield criteria for chest radiography in acute exacerbation of chronic obstructive pulmonary disease. Ann Emerg Med. 1993;22:780–4. doi: 10.1016/s0196-0644(05)81847-5. [DOI] [PubMed] [Google Scholar]

[CR87] 87.Sherman S, Skoney JA, Ravikrishnan KP. Routine chest radiographs in exacerbations of chronic obstructive pulmonary disease. Diagnostic value. Arch Intern Med. 1989;149:2493–6. doi: 10.1001/archinte.149.11.2493. [DOI] [PubMed] [Google Scholar]

[CR88] 88.Tsai TW, Gallagher EJ, Lombardi G, Gennis P, Carter W. Guidelines for the selective ordering of admission chest radiography in adult obstructive airway disease. Ann Emerg Med. 1993;22:1854–8. doi: 10.1016/S0196-0644(05)80992-8. [DOI] [PubMed] [Google Scholar]

[CR89] 89.Bach PB, Brown C, Gelfand SE, McCroy DC. Management of acute exacerbations of chronic obstructive pulmonary disease: A summary and appraisal of published evidence. Ann Intern Med. 2001;134:600–20. doi: 10.7326/0003-4819-134-7-200104030-00016. [DOI] [PubMed] [Google Scholar]

[CR90] 90.Snow V, Lascher S, Mottur-Pielson C. Evidence base for management of acute exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 2001;134:595–9. doi: 10.7326/0003-4819-134-7-200104030-00015. [DOI] [PubMed] [Google Scholar]

[CR91] 91.Saint S, Bent S, Vittinghoff E, Grady D. Antibiotics in chronic obstructive pulmonary disease exacerbations. A metaanalysis. JAMA. 1995;273:957–60. doi: 10.1001/jama.273.12.957. [DOI] [PubMed] [Google Scholar]

[CR92] 92.Nouira S, Marghli S, Belghith M, Besbes L, Elatrous S, Abrough F. Once daily oral ofloxacin in chronic obstructive pulmonary disease exacerbation, requiring mechanical ventilation: A randomised placebo-controlled trial. Lancet. 2001;358:2020–5. doi: 10.1016/S0140-6736(01)07097-0. [DOI] [PubMed] [Google Scholar]

[CR93] 93.Allegra L, Blasi F, de Bernardi B, Cosentini R, Tarsia P. Antibiotic treatment and baseline severity or disease in acute exacerbations of chronic bronchitis: A re-evaluation of previously published data of a placebo-controlled randomized study. Pulm Pharmaco Therapeut. 2001;14:149–55. doi: 10.1006/pupt.2001.0289. [DOI] [PubMed] [Google Scholar]

[CR94] 94.Anthonisen N, Manfreda J, Warren C, Hersfield E, Harding G, Nelson N. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Int Med. 1987;106:196–204. doi: 10.7326/0003-4819-106-2-196. [DOI] [PubMed] [Google Scholar]

[CR95] 95.Adams SG, Melo J, Luther M, Anzueto A. Antibiotics are associated with lower relapse rates in outpatients with acute exacerbations of COPD. Chest. 2000;117:1345–52. doi: 10.1378/chest.117.5.1345. [DOI] [PubMed] [Google Scholar]

[CR96] 96.Niroumand M, Grossman R. Airway infection. Infect Dis Clin N Am. 1998;12:671–88. doi: 10.1016/S0891-5520(05)70204-X. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR97] 97.Miravitlles M, Murio C., Guerrero T. Factors associated with relapse after ambulatory treatment of acute exacerbations of chronic bronchitis. DAFNE Study Group. Eur Respir J. 2001;17:928–33. doi: 10.1183/09031936.01.17509280. [DOI] [PubMed] [Google Scholar]

[CR98] 98.Seemungal TAR, Donaldson GC, Paul EA, Bestall JC, Jeffries DJ, Wedzicha JA. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157:1418–22. doi: 10.1164/ajrccm.157.5.9709032. [DOI] [PubMed] [Google Scholar]

[CR99] 99.Saint S, Flaherty KR, Abrahamse P, Martinez FJ, Fendrick AM. Acute exacerbations of chronic bronchitis: Disease-specific issues that influence the cost-effectiveness of antimicrobial therapy. Clin Ther. 2001;23:499–512. doi: 10.1016/S0149-2918(01)80053-9. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR100] 100.Ball P, Harris J, Lowson D, Tillotson G, Wilson R. Acute infective exacerbations of chronic bronchitis. Q J Med. 1995;88:61–8. [PubMed] [Google Scholar]

[CR101] 101.Sethi S. Etiology and management of infection in chronic obstructive pulmonary disease. Clin Pulm Med. 1999;6:327–32. [Google Scholar]

[CR102] 102.Anzueto AR. Risk stratification in acute exacerbations of chronic bronchitis: When and how to treat. Consultant. 2002;41(Suppl 12):S5–12. [Google Scholar]

[CR103] 103.Flaherty KR, Saint S, Fendrick AM, Martinez FJ. The spectrum of acute bronchitis: Using baseline factors to guide empirical therapy. Postgrad Med. 2001;109:39–47. doi: 10.3810/pgm.2001.02.859. [DOI] [PubMed] [Google Scholar]

[CR104] 104.Niederman MS. Antimicrobial therapy for acute exacerbations of chronic bronchitis: A critical path and consensus. Consultant. 2002;42(Suppl 12):S39–44. [Google Scholar]

[CR105] 105.Dewan NA, Rafique S, Kanwar B, et al. Acute exacerbation of COPD: Factors associated with poor treatment outcome. Chest. 2000;117:662–71. doi: 10.1378/chest.117.3.662. [DOI] [PubMed] [Google Scholar]

[CR106] 106.Shah PM, Maesen FPV, Domann A, Vetter N, Fiss E, Wesch R. Levofloxacin versus cefuroxime axetil in the treatment of acute exacerbation of chronic bronchitis: Results of a randomized, double-blind study. J Antimicrob Chemother. 1999;43:529–39. doi: 10.1093/jac/43.4.529. [DOI] [PubMed] [Google Scholar]

[CR107] 107.Wilson R, Kubin R, Ballin I, et al. Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis. J Antimicrob Chemother. 1999;44:501–13. doi: 10.1093/jac/44.4.501. [DOI] [PubMed] [Google Scholar]

[CR108] 108.Martinez FJ. The impact of antimicrobial selection on AECB: Resistance patterns of common respiratory pathogens. Consultant. 2002;42(Suppl 12):S33–8. [Google Scholar]

[CR109] 109.Doern GV. Antimicrobial use and the emergency of antimicrobial resistance with Streptococcus pneumoniae in the United States. Clin Inf Dis. 2001;33(Suppl 3):S187–92. doi: 10.1086/321847. [DOI] [PubMed] [Google Scholar]

[CR110] 110.Seaton RA, Steinke DT, Phillips G, MacDonald T, Davey PG. Community antibiotic therapy, hospitialization and subsequent respiratory tract isolation of Haemophilus influenzae resistance to amoxycillin: A nested case-control study. J Antimicrob Chemother. 2000;46:307–9. doi: 10.1093/jac/46.2.307. [DOI] [PubMed] [Google Scholar]

[CR111] 111.Thornsberry C, Sahm DF, Kelly LJ, et al. Regional trends in antimicrobial resistance among clinical isolates of Streptococcus pneumomiae, Haemophilus influenzae, and Moraxella catarrhalis in the United States: Results from the TRUST surveillance program, 1999–2000. Clin Inf Dis. 2002;34(Suppl 1):S4–S16. doi: 10.1086/324525. [DOI] [PubMed] [Google Scholar]

[CR112] 112.Lynch JP, III, Martinez FJ. Clinical relevance of macrolide-resistant Streptococcus pneumoniae for community acquired pneumonia. Clin Inf Dis. 2002;34(Suppl 1):S27–46. doi: 10.1086/324527. [DOI] [PubMed] [Google Scholar]

[CR113] 113.Hyde TB, Gay K, Stephens DS, et al. Macrolide resistance among invasive Streptococcus pneumoniae isolates. JAMA. 2001;285:1857–62. doi: 10.1001/jama.286.15.1857. [DOI] [PubMed] [Google Scholar]

[CR114] 114.Blondeau JM. A review or the comparative in-vitro activities of 12 antimicrobial agents, with a focus on five new ‘respiratory quinolones’. J Antimicrob Chemother. 1999;43(Suppl B):1–11. doi: 10.1093/jac/43.suppl_2.1. [DOI] [PubMed] [Google Scholar]

[CR115] 115.Thomson KS, Chartrand SA, Sanders CC, Block SL. In-vitro activity of levofloxacin against Streptococcus pneumoniae with various levels of penicillin resistance. J Antimicrob Chemother. 1999;43(Suppl C):15–9. doi: 10.1093/jac/43.suppl_3.15. [DOI] [PubMed] [Google Scholar]

[CR116] 116.Ho PL, Yung RWH, Tsang DNC, et al. Increasing resistance of Streptococcus pneumoniae to fluoroquinolones: Results of a Hong Kong multicenter study in 2000. J Antimicrob Chemother. 2001;48:659–65. doi: 10.1093/jac/48.5.659. [DOI] [PubMed] [Google Scholar]

[CR117] 117.Chen DK, McGeer A, De Azavedo JC, Low DE. Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. N Engl J Med. 1999;341:233–9. doi: 10.1056/NEJM199907223410403. [DOI] [PubMed] [Google Scholar]

[CR118] 118.Brueggemann AB, Coffman SL, Rhomberg P, et al. Fluoquinolone resistance in Streptococcus pneumoniae in United States since 1994–1995. Antimicrob Agent Chemother. 2002;46:680–8. doi: 10.1128/AAC.46.3.680-688.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR119] 119.Daily P, Gelling L, Rothrock G, et al. Resistance of Streptococcus pneumoniae to fluoroquinolones—United States, 1995–1999. MMWR Morb Mortal Wkly Rep. 2001;50:800–4. [PubMed] [Google Scholar]

[CR120] 120.Ho PL, Tse WS, Tsang KWT, et al. Risk factors for acquisition of levofloxacin-resistance Streptococcus pneumoniae: A case-control study. Clin Inf Dis. 2001;32:701–7. doi: 10.1086/319222. [DOI] [PubMed] [Google Scholar]

[CR121] 121.Doern GV, Jones RN, Pfaller MA, Kugler K. The SENTRY Participants Group. Haemophilus influenzae and Moraxella catarrhalis from patients with community-acquired respiratory tract infections: Antimicrobial susceptibility patterns from the SENTRY antimicrobial surveillance program (United States and Canada, 1997) J Antimicrob Chemother. Antimicrob Agent Chemother. 1999;43:385–9. doi: 10.1128/aac.43.2.385. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR122] 122.Richter SS, Brueggemann AB, Huynh HK, et al. A 1997–1998 national surveillance study: Moraxella catarrhalis and Haemophilus influenzae antimicrobial resistance in 34 US insitutions. Int J Antimicrob Agent. 1999;13:99–107. doi: 10.1016/S0924-8579(99)00112-0. [DOI] [PubMed] [Google Scholar]

[CR123] 123.Zhanel GG, Karlowsky JA, Low DE, Hoban DJ. Antibiotic resistance in respiratory tract isolates of Haemophilus influenzae and Moraxella catarrhalis collected from across Canada in 1997–1998. J Antimicrob Chemother. 2000;45:655–62. doi: 10.1093/jac/45.5.655. [DOI] [PubMed] [Google Scholar]

[CR124] 124.Murphy TF, Sethi S, Klingman KL, Brueggemann AB, Doern GV. Simultaneous respiratory tract colonization by multiple strains of nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease: Implications for antibiotic therapy. J Infect Dis. 1999;180:404–9. doi: 10.1086/314870. [DOI] [PubMed] [Google Scholar]

[CR125] 125.Verduin CM, Hol C, Fleer A, van Belkum A. Moraxella catarrhalis: From emerging to established pathogen. Clin Microbial Rev. 2002;15:125–44. doi: 10.1128/CMR.15.1.125-144.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR126] 126.Pechere JC, Lacey L. Optimizing economic outcomes in antibiotic therapy of patients with acute bacterial exacerbations of chronic bronchitis. J Antimicrob Chemother. 2000;45:19–24. doi: 10.1093/jac/45.suppl_2.19. [DOI] [PubMed] [Google Scholar]

[CR127] 127.Madaras-Kelly KJ, Magdanz SB, Johnson CK, Jue SG. Clinical outcomes of ambulatory acute exacerbations of chronic bronchitis with older versus newer antimicrobials. Ann Pharmacother. 2002;36:975–80. doi: 10.1345/aph.1A315. [DOI] [PubMed] [Google Scholar]

[CR128] 128.Wilson R, Schentag JJ, Ball P, Mandell L. A comparison of gemifloxacin and clarithromycin in acute exacerbations of chronic bronchitis and long-term clinical outcomes. Clin Ther. 2002;24:639–52. doi: 10.1016/S0149-2918(02)85139-6. [DOI] [PubMed] [Google Scholar]

[CR129] 129.Weiss K, Restieri C, Gauthier R, et al. A nosocomial outbreak of fluoroquinolone-resistant Streptococcus pneumoniae. Clin Inf Dis. 2001;33:517–22. doi: 10.1086/322658. [DOI] [PubMed] [Google Scholar]

[CR130] 130.DeAbate CA, Russell M, McElvaine P, et al. Safety and efficacy of oral levofloxacin versus cefuroxime axetil in acute bacterial exacerbation of chronic bronchitis. Respir Care. 1997;42:206–13. [Google Scholar]

[CR131] 131.Habib MP, Gentry LO, Rodriguez-Gomez G, et al. Multicenter, randomized study comparing efficacy and safety of oral levofloxacin and cefaclor in treatment of acute bacterial exacerbations of chronic bronchitis. Infect Dis Clin Pract. 1998;7:101–9. doi: 10.1097/00019048-199802000-00009. [DOI] [Google Scholar]

[CR132] 132.Anzuelo A, Niederman MS, Tillotson GS, Bronchitis Study Group Etiology, susceptibility, and treatment of acute bacterial exacerbations of complicated chronic bronchitis in the primary care setting: Ciprofloxacin 750 mg bid versus clarithromycin 500 mg bid. Clin Ther. 1998;20:835–50. doi: 10.1016/s0149-2918(98)80071-4. [DOI] [PubMed] [Google Scholar]

[CR133] 133.Chodosh S, Schreurs A, Siami G, Group Bronchitis Study et al. Efficacy of oral ciprofloxacin vs clarithromycin for treatment of acute bacterial exacerbations of chronic bronchitis. Clin Inf Dis. 1998;27:730–8. doi: 10.1086/514934. [DOI] [PubMed] [Google Scholar]

[CR134] 134.Grossman R, Mukherjee J, Vaughan D, et al. A 1-year community-based health economic study of ciprofloxacin vs usual antibiotic treatment in acute exacerbations of chronic bronchitis. The Canadian Ciprofloxacin Health Economic Study Group. Chest. 1998;113:131–41. doi: 10.1378/chest.113.1.131. [DOI] [PubMed] [Google Scholar]

[CR135] 135.Torrance G, Walker V, Grossman R, et al. Economic evaluation of ciprofloxacin compared with usual antibacterial care for the treatment of acute exacerbations of chronic bronchitis in patients followed for 1 year. Pharmacoeconomics. 1999;16:499–520. doi: 10.2165/00019053-199916050-00007. [DOI] [PubMed] [Google Scholar]

[CR136] 136.Destache CJ, Dewan N, O’Donohue WJ, Campbell JC, Angelillo VA. Clinical and economic considerations in the treatment of acute exacerbations of chronic bronchitis. J Antimicrob Chemother. 1999;43(Suppl A):107–113. doi: 10.1093/jac/43.suppl_1.107. [DOI] [PubMed] [Google Scholar]

[CR137] 137.Stoller JK. Acute exacerbations of chronic obstructive pulmonary disease. N Engl J Med. 2002;346:988–94. doi: 10.1056/NEJMcp012477. [DOI] [PubMed] [Google Scholar]

[CR138] 138.McCroy DC, Brown C, Gelfand SE, Bach PB. Management of exacerbations of COPD: A summary and appraisal of the published evidence. Chest. 2001;119:1190–209. doi: 10.1378/chest.119.4.1190. [DOI] [PubMed] [Google Scholar]

[CR139] 139.Singh JM, Palda VA, Stanbrook MB, Chapman KR. Corticosteroid therapy for patients with acute exacerbations of chronic obstructive pulmonary disease. A systematic review. Arch Intern Med. 2002;162:2527–36. doi: 10.1001/archinte.162.22.2527. [DOI] [PubMed] [Google Scholar]

[CR140] 140.Niewoehner DE, Erbland ML, Deupree RH, Department of Veterans Affairs Cooperative Study Group et al. Effect of systemic glucocorticoids on exacerbationsis of chronic obstructive pulmonary disease. N Engl J Med. 1999;340:1941–7. doi: 10.1056/NEJM199906243402502. [DOI] [PubMed] [Google Scholar]

[CR141] 141.Sayner A, Aytemur AZ, Cirit M, Unsal I. Systemic glucocorticoids in severe exacerbations of COPD. Chest. 2001;119:726–30. doi: 10.1378/chest.119.3.726. [DOI] [PubMed] [Google Scholar]

[CR142] 142.Davies L, Nisar M, Pearson MG, Costello RW, Earis JE, Calverley PMA. Oral corticosteroid trials in the management of stable chronic obstructive pulmonary disease. Q J Med. 1999;92:395–400. doi: 10.1093/qjmed/92.7.395. [DOI] [PubMed] [Google Scholar]

[CR143] 143.Maltais F, Ostinelli J, Bourbeau J, et al. Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: A randomized controlled trial. Am J Respir Crit Care Med. 2002;165:698–703. doi: 10.1164/ajrccm.165.5.2109093. [DOI] [PubMed] [Google Scholar]

[CR144] 144.Sethi S. Infectious exacerbations of chronic bronchitis: diagnosis and management. J Antimicrob Chemother. 1999;43(Suppl A):97–105. doi: 10.1093/jac/43.suppl_1.97. [DOI] [PubMed] [Google Scholar]

[CR145] 145.Dere WH. Acute bronchitis: Results of U.S. and European trials of antibiotic therapy. Am J Med. 1992;92(Suppl 6A):53S–7S. doi: 10.1016/0002-9343(92)90608-E. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR146] 146.Jonsson JS, Sigurdsson JA, Kristinsson KG, Guthnadottir M, Magnusson S. Acute bronchitis in adults. How close do we come to its aetiology in general practice? Scand J Prim Health Care. 1997;15:156–60. doi: 10.3109/02813439709018507. [DOI] [PubMed] [Google Scholar]

[CR147] 147.Ball P. Epidemiology and treatment of chronic bronchitis and its exacerbations. Chest. 1995;108:43S–52S. doi: 10.1378/chest.108.2_Supplement.43S. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR148] 148.Gwaltney JM., Jr. Acute bronchitis. In: Mandell G., Bennett J., Dolin R., editors. Mandell: Principles and Practice of Infectious Disease. 5th ed. Philadelphia: Churchill Livingstone; 2000. pp. 703–6. [Google Scholar]

[CR149] 149.Kaiser L, Lew D, Hirschel B, et al. Effects of antibiotic, treatment in the subset of common-cold patients who have bacteria in nasopharyngeal secretions. Lancet. 1996;347:1507–10. doi: 10.1016/S0140-6736(96)90670-4. [DOI] [PubMed] [Google Scholar]

[CR150] 150.Falck G, Heyman L, Gnarpe J, Gnarpe H. Chlamydia Pneumoniae (TWAR): A common agent in acute bronchitis. Scand J Infect Dis. 1994;26:179–87. doi: 10.3109/00365549409011782. [DOI] [PubMed] [Google Scholar]

[CR151] 151.Buscho RO, Saxtan D, Shultz PS, Finch E, Mufson MA. Infections with viruses and Mycoplasma pneumoniae during exacerbations of chronic bronchitis. J Infect Dis. 1978;137:377–83. doi: 10.1093/infdis/137.4.377. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR152] 152.Smith CB, Goldern CA, Kanner RE, Renzetti AD. Association of viral and Mycoplasma pneumoniae infections with acute respiratory illness in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1980;121:225–32. doi: 10.1164/arrd.1980.121.2.225. [DOI] [PubMed] [Google Scholar]

[CR153] 153.Herwaldt LA. Pertussis in adults: What physicians need to know. Arch Intern Med. 1991;151:1510–2. doi: 10.1001/archinte.151.8.1510. [DOI] [PubMed] [Google Scholar]

[CR154] 154.Falsey AR, McCann RM, Hall WJ, et al. The “common cold” in frail older persons: Impact of rhinovirus and coronavirus in a senior daycare center. JAGS. 1997;45:706–11. doi: 10.1111/j.1532-5415.1997.tb01474.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR155] 155.Hendley JO, Fishburne HB, Swaltney JM. Coronavirus infections in working adults: Eight-year study with 229 E and OC 43. Am Rev Respir Dis. 1972;105:805–11. doi: 10.1164/arrd.1972.105.5.805. [DOI] [PubMed] [Google Scholar]

[CR156] 156.Greenberg SB, Allen M, Wilson J, Atmar RL. Respiratory viral infections in adults with and without chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;162:167–73. doi: 10.1164/ajrccm.162.1.9911019. [DOI] [PubMed] [Google Scholar]

[CR157] 157.Rhode G, Wiethege A, Borg I, et al. Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: A case-control study. Thorax. 2003;58:37–42. doi: 10.1136/thorax.58.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR158] 158.Seemungal TA, Wedzicha JA, MacCallum PK, Johnston SL, Lambert PA. Chlamydia pneumoniae and COPD exacerbation. Thorax. 2002;57:1087–8. doi: 10.1136/thorax.57.12.1087-a. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR159] 159.Fahey T, Stocks N, Thomas T. Quantitative systematic review of randomised controlled trials comparing antibiotic with placebo for acute cough in adults. BMJ. 1998;316:906–10. doi: 10.1136/bmj.316.7135.906. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR160] 160.Smucny JJ, Becker LA, Glazier RH, McIsaac W. Are antibiotics effective treatment for acute bronchitis? A meta-analysis. J Fam Pract. 1998;47:453–60. [PubMed] [Google Scholar]

[CR161] 161.Bent S, Saint S, Vittinghoff E, Grady D. Antibiotics in acute bronchitis: A metal-analysis. Am J Med. 1999;07:62–7. doi: 10.1016/S0002-9343(99)00167-9. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR162] 162.Evans AT, Husain S, Durairaj L, Sadowski LS, Charles-Damte M, Wang Y. Azithromycin for acute bronchitis: A randomised, double-blind, controlled trial. Lancet. 2002;359:1648–54. doi: 10.1016/S0140-6736(02)08597-5. [DOI] [PubMed] [Google Scholar]

[CR163] 163.Lode H. Respiratory tract infections: When is antibiotic therapy indicated? Clin Ther. 1991;13:149–56. [PubMed] [Google Scholar]

[CR164] 164.Hueston W J. Albuterol delivered by metered-dose inhaler to treat acute bronchitis. J Fam Pract. 1994;39. [PubMed]

[CR165] 165.Grossman R. Guidelines for the treatment of acute exacerbations of chronic bronchitis. Chest. 1997;112(Suppl 6):311S–3S. doi: 10.1378/chest.112.6_supplement.310s. [DOI] [PubMed] [Google Scholar]

[CR166] 166.Wilson R. Outcome predictors in bronchitis. Chest. 1995;106(Suppl):53S–57S. doi: 10.1378/chest.108.2_supplement.53s. [DOI] [PubMed] [Google Scholar]

[CR167] 167.Adams SG, Anzueto A. Antibiotic therapy in acute exacerbations of chronic bronchitis: Part 1. The rationale. Pulm Perspect. 2002;19:6–8. [Google Scholar]

[CR168] 168.Adams SG, Anzueto A. Antibiotic therapy in acute exacerbations of chronic bronchitis: Part 2. Pul Perspect. 2002;19:1–5. doi: 10.1053/srin.2000.18077. [DOI] [PubMed] [Google Scholar]

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Acute bronchitis: State of the art diagnosis and therapy

Fernando J Martinez, MD, MS

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PERMALINK

Acute bronchitis: State of the art diagnosis and therapy

Fernando J Martinez, MD, MS

Abstract

Footnotes

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ACTIONS

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