Zusammenfassung
1. Die bronchokonstriktorische Wirkung von Propranololaerosol wurde an Meerschweinchen und an 5 Patienten mit Asthma bronchiale untersucht.
2. Beim Meerschwein gelang es regelmäßig durch die Einatmung von 12% Propranololaerosol schwere Dyspnoe hervorzurufen, die in ähnlicher Form auftrat wie beim anaphylaktischen Mikroschock.
3. Bei Asthmatikern mit nachweisbarer Bronchial-obstruktion wurde diese durch die Einatmung von 1- oder 5%igem Propranololaerosol regelmäßig verstärkt.
4. Atropin und Hexamethonium verminderten im Tierversuch und bei Patienten mit Asthma bronchiale signifikant die Propranololwirkung; Guanethidin und Mepyramin blieben wirkungslos.
Summary
1. The bronchoconstrictor effect of propranolol aerosol was investigated on guinea-pigs and on 5 patients with bronchial asthma.
2. In guinea-pigs a 12% propranolol aerosol regulare caused severe dyspnoea similar to that observed in the anaphylactic microshock.
3. The bronchial obstruction present in asthmatics became more pronounced after inhaling a 1% or 5% propranolol aerosol.
4. In guinea-pigs and in asthmatics the propranolol effect was significantly antagonized by atropine and by hexamethonium; guanethidine and mepyramine had no effect.
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