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. 1991;69(9):379–386. [Article in German] doi: 10.1007/BF01647409

Thrombozytentransfusion: Klinik, Kontrollen und Komplikationen

Platelet transfusion therapy: Clinical considerations, controls, and complications

D Söhngen 1, W Schneider 1
PMCID: PMC7095859  PMID: 1921239

The content is available as a PDF (872.6 KB).

Abkürzungsverzeichnis

ALL

akute lymphatische Leukämie

AML

akute myeloische Leukämie

ARDS

Adult Respiratory Distress Syndrome

BZ

Blutungszeit

CCI

Corrected Count Increment

CML

chronische myeloische Leukämie

CMV

Cytomegalievirus

DCT

direkter Coombstest

DIC

disseminierte intravasale Gerinnung

EK

Erythrozytenkonzentrat

GVHD

Graft Versus Host Disease

KG

Körpergewicht

KMT

Knochenmarktransplantation

PML

Promyelozytenleukämie

PRP

plättchenreiches Plasma

PTP

post-transfusionelle thrombozytopenische Purpura

SSA

schwere aplastische Anämie

TK

Thrombozytenkonzentrat

VK

Variationskoeffizient

Literatur

  • 1.Alter HJ, Purcell RH, Holland PV, et al. Donor transaminase and recipient hepatitis. Impact on blood transfusion services. J Am Med Assoc. 1981;246:630–634. [PubMed] [Google Scholar]
  • 2.Alter HJ, Purcell RH, Shih JW, et al. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med. 1989;231:1494–1500. doi: 10.1056/NEJM198911303212202. [DOI] [PubMed] [Google Scholar]
  • 3.Andrews AT, Zmijewski CM, Bowman HS, et al. Transfusion reaction with pulmonary infiltration associated with HLA specific leukocyte antibodies. Am J Clin Pathol. 1976;66:483–487. doi: 10.1093/ajcp/66.3.483. [DOI] [PubMed] [Google Scholar]
  • 4.Aster RH. Pooling of platelets in the spleen: role in the pathogeneses of “hypersplenic” thrombocytopenia. J Clin Invest. 1966;45:645–657. doi: 10.1172/JCI105380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Baldwin ML, Ness PM, Scott D, et al. Alloimmunization to D-antigen and HLA in D-negative immunosuppressed oncology patients. Transfusion. 1988;28:330–333. doi: 10.1046/j.1537-2995.1988.28488265260.x. [DOI] [PubMed] [Google Scholar]
  • 6.Boughton BJ et al. (1988) Thrombocytopenia after routine blood transfusion is prevented by microaggregate filtration. In: Book of Abstracts. XX. Congress of ISBT and BBTS, London, p 104
  • 7.Braine HG, et al. Bacterial sepsis secondary to platelet transfusion: an adverse effect of extended storage at room temperature. Transfusion. 1986;26:391–392. doi: 10.1046/j.1537-2995.1986.26486262752.x. [DOI] [PubMed] [Google Scholar]
  • 8.Buechner T, Hiddemann W. Treatment strategies in acute myeloid leukemia (AML) Blut. 1990;60:61–67. doi: 10.1007/BF01720509. [DOI] [PubMed] [Google Scholar]
  • 9.Consensus Conference. Platelet Transfusion Therapy JAMA. 1987;257:1777–1780. [PubMed] [Google Scholar]
  • 10.Daly PA, Schiffer CA, Aisner J, et al. Platelet transfusion therapy. JAMA. 1980;243:435–438. doi: 10.1001/jama.243.5.435. [DOI] [PubMed] [Google Scholar]
  • 11.Duke WW. The relation of blood platelets to hemorrhagic disease: description of a method for determining the bleeding time and coagulation time and report of three courses of hemorrhagic disease relieved by transfusion. JAMA. 1910;55:1185–1192. [Google Scholar]
  • 12.Eisenstaedt R. Blood component therapy in the treatment of platelet disorders. Semin Hematol. 1986;23:1–7. [PubMed] [Google Scholar]
  • 13.Gathof B, Eberle J, Bäcker V, et al. HIV-Infektion und Blutspendewesen. Internist. 1988;29:124–130. [PubMed] [Google Scholar]
  • 14.Gaxolos LA, Freireich EJ, Mantel N. The quantitative relation between platelet count and hemorrhage in patients with acute leukemia. N Engl J Med. 1962;266:905–909. doi: 10.1056/NEJM196205032661802. [DOI] [PubMed] [Google Scholar]
  • 15.Harker LA, Slichter SJ. The bleeding time as a screening test for evaluation of platelet function. N Engl J Med. 1972;287:155–159. doi: 10.1056/NEJM197207272870401. [DOI] [PubMed] [Google Scholar]
  • 16.Hartert HH. Resonance Thrombography. Theoretical and practical aspects. Biorheology. 1981;18:693–701. doi: 10.3233/bir-1981-183-631. [DOI] [PubMed] [Google Scholar]
  • 17.Hathaway WE. The bleeding newborn. Semin Hematol. 1975;12:175–188. [PubMed] [Google Scholar]
  • 18.Heal JM, Singal S, Sardisco E, et al. Bacterial proliferation in platelet concentrates. Transfusion. 1986;26:388–389. doi: 10.1046/j.1537-2995.1986.26486262751.x. [DOI] [PubMed] [Google Scholar]
  • 19.Hendersen ES, Lister TA, editors. Leukemia. 5th ed. Philadelphia London Toronto Montreal Sydney Tokyo: Saunders; 1990. pp. 711–731. [Google Scholar]
  • 20.Heyman MR, Schiffer CA. Platelet transfusion therapy for the cancer patient. Semin Oncol. 1990;17:198–209. [PubMed] [Google Scholar]
  • 21.Higby DJ, Burnett D. Granulocyte transfusions: Current status. Blood. 1980;55:2–8. [PubMed] [Google Scholar]
  • 22.Higby DJ, Cohen E, Holland JF, et al. The prophylactic treatment of thrombocytopenic leukemic patients with platelets: a double blind study. Transfusion. 1974;14:440–446. doi: 10.1111/j.1537-2995.1974.tb04558.x. [DOI] [PubMed] [Google Scholar]
  • 23.Höcker P, Hinterberger W, Lechner K, et al. Supportive Therapie mit Thrombozytenkonzentraten bei Patienten mit akuter Leukämie. Beitr Infusionsther Klin Ernähr. 1987;18:115–122. [PubMed] [Google Scholar]
  • 24.Hutchinson RE, Schell MJ, Nelson EJ, et al. Beneficial effect of brief pretransfusion incubation of platelets at 37° C. Lancet. 1989;6:986–988. doi: 10.1016/s0140-6736(89)92629-9. [DOI] [PubMed] [Google Scholar]
  • 25.International Forum Which are the parameters to be controlled in platelet concentrates in order that they may be offered to the medical profession as a standardized product with specific properties? Vox Sang. 1981;40:115–126. [PubMed] [Google Scholar]
  • 26.Kratzer MA, Born GV. Simulation of primary haemostasis in vitro. Haemostasis. 1985;15:357–362. doi: 10.1159/000215173. [DOI] [PubMed] [Google Scholar]
  • 27.Kretschmer V. Verschiedene Aspekte der Thrombozytentransfusion. In: Peter K, Groh J, editors. Anästhesiologie und Intensivmedizin — ZAK München 1987, Bd IV — Hauptthemen. Berlin Heidelberg New York Tokyo: Springer; 1988. pp. 175–190. [Google Scholar]
  • 28.Kretschmer V. Side effects and technical problems in cytopheresis with cell separators. Results of a retrospective multicenter study. Infusionsther. 1987;14(suppl 4):7–16. doi: 10.1159/000226199. [DOI] [PubMed] [Google Scholar]
  • 29.Kretschmer V, Schikor B, Söhngen D, et al. In vitro bleeding test — a sensitive method for the detection of platelet function impairment and a potential test for the control of low-dose aspirin efficacy. Blut. 1989;59:188. doi: 10.1007/BF00320066. [DOI] [PubMed] [Google Scholar]
  • 30.Kretschmer V, Schikor B, Söhngen D, et al. In vitro bleeding test — a simple method for the detection of aspirin effects on platelet function. Thromb Res. 1989;56:593–602. doi: 10.1016/0049-3848(89)90267-3. [DOI] [PubMed] [Google Scholar]
  • 31.Lasky LC, Warkentin PI, Kersey JH, et al. Hemotherapy in patients undergoing blood group incompatible bone marrow transplantation. Transfusion. 1983;23:277–285. doi: 10.1046/j.1537-2995.1983.23483276858.x. [DOI] [PubMed] [Google Scholar]
  • 32.Lichtiger B, Surgeon J, Rhorer S. Rh-incompatible platelet transfusion therapy in cancer patients. Vox Sang. 1983;45:139–143. doi: 10.1111/j.1423-0410.1983.tb01898.x. [DOI] [PubMed] [Google Scholar]
  • 33.Loos JA, van Aken WG. Herstellung von Blutkomponenten. In: Müller-Eckhardt C, editor. Transfusionsmedizin. Berlin Heidelberg New York London Paris Tokyo: Springer; 1988. pp. 232–244. [Google Scholar]
  • 34.Marx R, Thies HA. Herzinfarkt und Blutgerinnung. Stuttgart: Schattauer; 1972. pp. 1185–1192. [Google Scholar]
  • 35.McLeod BC, Sassetti RJ, Weens JH, et al. Haemolytic transfusion reaction due to ABO incompatible plasma in a platelet concentrate. Scand J Haematol. 1982;28:193–196. doi: 10.1111/j.1600-0609.1982.tb00514.x. [DOI] [PubMed] [Google Scholar]
  • 36.Mielke CHJ, Kaneshiro MM, Maher IA, et al. The standardized normal Ivy bleeding time and its prolongation by aspirin. Blood. 1969;34:204–215. [PubMed] [Google Scholar]
  • 37.Moroff G, George M, Siegl M, et al. The influence of irradiation on stored platelets. Transfusion. 1986;26:453–456. doi: 10.1046/j.1537-2995.1986.26587020124.x. [DOI] [PubMed] [Google Scholar]
  • 38.Müller-Eckhardt C, editor. Transfusionsmedizin. Berlin Heidelberg New York London Paris Tokyo: Springer; 1988. pp. 367–372. [Google Scholar]
  • 39.Müller-Eckhardt C. Annotation, Posttransfusion purpura. Br J Haematol. 1986;64:419–424. doi: 10.1111/j.1365-2141.1986.tb02198.x. [DOI] [PubMed] [Google Scholar]
  • 40.Pierce RN, Reich LM, Mayer K. Hemolyses following platelet transfusions from ABO-incompatible donors. Transfusion. 1985;25:60–62. doi: 10.1046/j.1537-2995.1985.25185116506.x. [DOI] [PubMed] [Google Scholar]
  • 41.Racz Z, Thék M. Buffy Coat or Platelet-Rich Plasma? Vox Sang. 1984;47:108–113. doi: 10.1111/j.1423-0410.1984.tb01571.x. [DOI] [PubMed] [Google Scholar]
  • 42.Roelcke D. Komplikationen und Nebenwirkungen von Bluttransfusionen. In: Müller-Eckhardt C, editor. Transfusionsmedizin. Berlin Heidelberg New York London Paris Tokyo: Springer; 1988. pp. 554–589. [Google Scholar]
  • 43.Seidl S, Kühnl P. Durch Bluttransfusion übertragbare Infektionskrankheiten. In: Müller-Eckhardt C, editor. Transfusionsmedizin. Berlin Heidelberg New York London Paris Tokyo: Springer; 1988. pp. 592–611. [Google Scholar]
  • 44.Shulman NR, Jordan JV, et al. Platelet Kinetics. In: Colman RW, Hirsh J, Marder VJ, et al., editors. Hemostasis and Thrombosis. Basic Principles and Clinical Practice nd edn. Philadelphia London St Louis Sao Paulo Sydney: Lippincott; 1987. pp. 431–451. [Google Scholar]
  • 45.Sibinga CTS. Platelets for Transfusion: Collection, Processing and Preservation Aspects. Blut. 1987;55:475–481. doi: 10.1007/BF00320214. [DOI] [PubMed] [Google Scholar]
  • 46.Simon TL. Platelets: Uses, Abuses and Indications. In: Kolins J, McCarthy LJ, editors. Contemporary Transfusion Practice. Arlington: American Association of Blood Banks; 1987. pp. 47–63. [Google Scholar]
  • 47.Slichter SJ. Controversies in platelet transfusion therapy. Ann Rev Med. 1980;31:509–540. doi: 10.1146/annurev.me.31.020180.002453. [DOI] [PubMed] [Google Scholar]
  • 48.Söhngen D, Schröter A, Saure A, et al. Thrombozytenlagerung als plättchenreiche Plasmen (PRP) oder Konzentrate (TK) Beitr Infusionsther Klin Ernähr. 1988;21:91–99. [PubMed] [Google Scholar]
  • 49.Söhngen D, Lies M, Kretschmer V, Egbring R. Thrombozytenfunktion in vitro bei 5-Tage-Lagerung. Beitr Infusionsther Klin Ernähr. 1987;18:163–166. [PubMed] [Google Scholar]
  • 50.Solomon J, Bofenkamp T, Fahey JL, et al. Platelet prophylaxis in acute non-Lymphoblastic Leukaemia. Lancet. 1978;4:267. doi: 10.1016/s0140-6736(78)90505-6. [DOI] [PubMed] [Google Scholar]
  • 51.Sonntag VHK. Malaria transmission by platelet concentrate transfusion. JAMA. 1978;240:2285–2286. [PubMed] [Google Scholar]
  • 52.Stangel W. Gewinnung, Konservierung, Lagerung von Transfusionsblut. In: Müller-Eckhardt C, editor. Transfusionsmedizin. Berlin Heidelberg New York London Paris Tokyo: Springer; 1988. pp. 204–229. [Google Scholar]
  • 53.Storb R, Weiden PL. Transfusion problems associated with transplantation. Semin Hematol. 1981;18:163–176. [PubMed] [Google Scholar]
  • 54.Sugg V, Schenzle D, Hess G. Antibodies to hepatitis B core antigen in blood donors screened for alanine aminotransferase level and hepatitis non-A, non-B in recipients. Transfusion. 1988;28:386–388. doi: 10.1046/j.1537-2995.1988.28488265274.x. [DOI] [PubMed] [Google Scholar]
  • 55.The Lancet (1990) ABO incompatibility and platelet transfusion. 335:142–143 [PubMed]
  • 56.Thomson JS, Severson CD, Parmely MJ, et al. Pulmonary “hypersensitivity” reactions induced by transfusion of NonHLA leucoagglutinins. N Engl J Med. 1971;20:1120–1125. doi: 10.1056/NEJM197105202842003. [DOI] [PubMed] [Google Scholar]
  • 57.Tomasulo PA, Lenes BA. Platelet Transfusion Therapy. In: Menitove JE, McCarthy LJ, editors. Hemostatic Disorders and the Blood Bank. Arlington: American Association of Blood Banks; 1984. pp. 63–89. [Google Scholar]
  • 58.Wernet P, Schnaidt M, Mayer G, et al. Die Tübinger Konzeption der transfusionsmedizinischen Versorgung bei Knochenmarktransplantationen. Beitr Infusionsther Klin Ernähr. 1987;18:23–127. [PubMed] [Google Scholar]
  • 59.Wiesneth M. Transfusionsstrategie bei der Substitution mit Thrombozyten und Granulozyten. Beitr Infusionsther Klin Ernähr. 1987;18:108–114. [PubMed] [Google Scholar]

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