Summary
Thrombocytopenia is the most common cause of bleeding tendency, and, if due to impaired platelet production, is best treated by platelet transfusions. Prophylactic transfusions for asymptomatic patients should be considered if platelet count is below 20000/μl. However, if bleeding occurs or surgery is inevitable, platelet count should be maintained above 50000/μl. The benefit of platelet transfusions has to be balanced against risks like fever, infections and haemolysis.
The effectiveness of platelet transfusions should be examined after 1 and 24 hrs by measuring the corrected count increment (CCI). Not only alloimmunization is a reason for unsatisfactory platelet increments. A poor CCI can also be due to fever, sepsis, hepato-splenomegaly or special drugs, which must be taken into account when assessing the demand for platelet transfusions.
Key words: Platelet transfusion therapy, White cell-depleted blood products, Corrected Count Increment (CCI)
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Abkürzungsverzeichnis
- ALL
akute lymphatische Leukämie
- AML
akute myeloische Leukämie
- ARDS
Adult Respiratory Distress Syndrome
- BZ
Blutungszeit
- CCI
Corrected Count Increment
- CML
chronische myeloische Leukämie
- CMV
Cytomegalievirus
- DCT
direkter Coombstest
- DIC
disseminierte intravasale Gerinnung
- EK
Erythrozytenkonzentrat
- GVHD
Graft Versus Host Disease
- KG
Körpergewicht
- KMT
Knochenmarktransplantation
- PML
Promyelozytenleukämie
- PRP
plättchenreiches Plasma
- PTP
post-transfusionelle thrombozytopenische Purpura
- SSA
schwere aplastische Anämie
- TK
Thrombozytenkonzentrat
- VK
Variationskoeffizient
Literatur
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