In the original article, there was a mistake in Tables 1–4 as published. The units for Procalcitonin (PCT) concentration were erroneously stated as ng/mL, but should be stated as pg/mL. The corrected Tables appear below.
Table 1.
Comparisons of blood biomarker concentration with effusion biomarker concentrations in dogs with septic peritonitis (SP) and in dogs with non-septic peritonitis (NSA).
| SP | NSA | |||||||
|---|---|---|---|---|---|---|---|---|
| Blood median IQR | Effusion median IQR | P-value | Pcorr | Blood median IQR | Effusion median IQR | P-value | Pcorr | |
| Glucose (mg/dL) | 111 | 20 | 0.0011 | 0.0121 | 101 | 94 | 0.1648 | 1.8128 |
| 81–124 | 20–108 | 79–118 | 78–99 | |||||
| Glucose (mmol/L) | 6.2 | 1.1 | 0.0011 | 0.0121 | 5.6 | 5.2 | 0.1648 | 1.8128 |
| 4.5–6.9 | 1.1–6.0 | 4.4–6.6 | 4.4–5.5 | 0.1648 | 1.8128 | |||
| Lactate (mmol/L) | 2.7 | 7.9 | 0.0066 | 0.0726 | 2.0 | 1.8 | 0.6998 | 7.6978 |
| 1.2–4.2 | 2.7–11.3 | 1.3–2.6 | 1.1–2.8 | |||||
| cfDNA (ng/mL) | 379 | 1085 | 0.0003 | 0.0033 | 410 | 470 | 0.7381 | 8.1191 |
| 316–430 | 493–2723 | 316–629 | 269–1157 | |||||
| Nucleosomes (AU) | 0.35 | 13.1 | 0.0001 | 0.0011 | 0.6 | 2.5 | 0.0289 | 0.1848 |
| 0.2–1.1 | 4.4–25.1 | 0.3–1.8 | 0.3–12.9 | |||||
| NT–proCNP (pmol/L) | 11.9 | 6.2 | 0.2460 | 2.910 | 3.9 | 2.3 | 0.1134 | 1.333 |
| 5.6–42.1 | 1.9–25.7 | 2.3–12.0 | 1.6–10.3 | |||||
| PCT (pg/mL) | 99.6 | 38.4 | 0.0028 | 0.0352 | 93.5 | 98.9 | 0.6226 | 6.8486 |
| 40.3–182.9 | 0.0–119.2 | 54.7–208.1 | 29.7–201.6 | |||||
| CCL2 (pg/mL) | 1274 | 16066 | 0.0001 | 0.0011 | 249 | 683 | 0.0001 | 0.0011 |
| 282–2715 | 2508–96300 | 21–431 | 449–2225 | |||||
| CXCL8 (pg/mL) | 785.4 | 4325.0 | 0.0090 | 0.099 | 550.3 | 129.6 | 0.1901 | 2.0911 |
| 495.6–1857.0 | 21.7–75000.0 | 51.8–1372.0 | 21.7–444.7 | |||||
| IL-10 (pg/mL) | 8.5 | 303.1 | 0.0012 | 0.0132 | 8.5 | 8.5 | 0.0312 | 0.3432 |
| 8.5–106.4 | 147.6–1584.0 | 8.5–8.5 | 8.5–31.9 | |||||
| IL-6 (pg/mL) | 9.9 | 2775.0 | 0.0001 | 0.0011 | 3.7 | 37.9 | 0.0029 | 0.0319 |
| 3.7–1573.0 | 363.5–11495.0 | 3.7–15.9 | 3.7–1918.0 | |||||
| KC-Like (pg/mL) | 164.1 | 1215.0 | 0.0011 | 0.0121 | 20.3 | 456.2 | 0.0001 | 0.0011 |
| 8.0–1137.0 | 37.2–6973.0 | 5.3–71.5 | 62.1–757.0 | |||||
Median and IQR concentrations of measured biomarkers in blood and effusion in patients with SP and NSA, and results of univariate comparisons of biomarker concentrations between fluid types with each group by Wilcoxon matched-pairs signed rank test. Biomarkers significantly different after correction for multiple comparisons (P <0.05) between blood and effusion within SP and NSA groups are indicated in bold typeface. AU, arbitrary unit; CCL2, C-C Motif Chemokine Ligand-2; cfDNA, cell-free DNA; CXCL8, chemokine C-X-C motif ligand 8; IL, interleukin; IQR, interquartile range; KC-Like, keratinocyte chemoattractant-like; NSA, non-septic ascites; NT-proCNP, amino-terminal propeptide of C-type natriuretic peptide; Pcorr, P-value corrected for multiple comparisons; PCT, procalcitonin; SP, septic peritonitis.
Table 4.
Comparisons of blood-effusion biomarker concentration gradients in dogs with septic peritonitis (SP) and non-septic peritonitis (NSA).
| Blood-Effusion Gradient | ||||
|---|---|---|---|---|
| SP median IQR | NSA median IQR | P-value | Pcorr | |
| Glucose (mg/dL) | 59 | 6 | 0.0009 | 0.0099 |
| 16–91 | −6–27 | |||
| Glucose (mmol/L) | 3.3 | 0.3 | 0.0009 | 0.0099 |
| 0.9–5.1 | −0.3–1.5 | |||
| Lactate (mmol/L) | −4.9 | 0.2 | 0.0015 | 0.0165 |
| −8.5 to −0.5 | −0.9–0.6 | |||
| cfDNA (ng/mL) | −757 | −31 | 0.005 | 0.055 |
| −2331 to −179 | −527–165 | |||
| Nucleosomes (AU) | −13.0 | −0.7 | 0.0066 | 0.0726 |
| −22.5 to −3.4 | −12.8–0.3 | |||
| NT-proCNP (pmol/L) | 2.4 | 0.8 | 0.3744 | 4.1624 |
| −1.6–7.4 | −0.5–2.6 | |||
| PCT (pg/mL) | 27.9 | 22.4 | 0.0861 | 0.9471 |
| 8.3–98.7 | −32.7–33.7 | |||
| CCL2 (pg/mL) | −14151 | −561 | 0.0006 | 0.0066 |
| −91817 to −2243 | −1827 to −110 | |||
| CXCL8 (pg/mL) | −3657.0 | 134.1 | 0.0129 | 0.1419 |
| −68631.0–623.7 | −51.1–1316.0 | |||
| IL-10 (pg/mL) | −294.6 | 0.0 | 0.0004 | 0.0044 |
| −1430.0 to −63.8 | −23.4 to 0.0 | |||
| IL-6 (pg/mL) | −2772.0 | −0.5 | 0.0009 | 0.0099 |
| −10272.0 to −359.8 | −1914.0 to 0.0 | |||
| KC-Like (pg/mL) | −937.3 | −425.5 | 0.3786 | 4.1646 |
| −4615.0 to −31.9 | −716.7 to −41.3 | |||
Median and IQR blood-effusion concentration gradients of measured biomarkers in patients with SP and NSA, and results of univariate comparisons of biomarker concentration gradients between groups by Mann-Whitney U-test. Biomarker bloodeffusion gradients identified to be significantly different compared between SP and NSA groups after correction for multiple comparisons (P <0.05) are indicated in bold typeface. AU, arbitrary unit; CCL2, C-C Motif Chemokine Ligand-2; cfDNA, cell-free DNA; CXCL8, chemokine C-X-C motif ligand 8; IL, interleukin; IQR, interquartile range; KC-Like, keratinocyte chemoattractant-like; NSA, non-septic ascites; NT-proCNP, amino-terminal propeptide of C-type natriuretic peptide; Pcorr, P value corrected formultiple comparisons; PCT, procalcitonin; SP, septic peritonitis.
Table 2.
Comparisons of blood biomarker concentrations in dogs with septic peritonitis (SP) and non-septic peritonitis (NSA).
| Blood | ||||
|---|---|---|---|---|
| SP median IQR | NSA median IQR | P-value | Pcorr | |
| Glucose (mg/dL) | 111 | 101 | 0.7927 | 8.7197 |
| 81–124 | 79–118 | |||
| Glucose (mmol/L) | 6.2 | 5.6 | 0.7927 | 8.7197 |
| 4.5–6.9 | 4.4–6.6 | |||
| Lactate (mmol/L) | 2.7 | 2.0 | 0.3698 | 4.0678 |
| 1.2–4.2 | 1.3–2.6 | |||
| cfDNA (ng/mL) | 379 | 410 | 0.3953 | 4.3483 |
| 316–430 | 316–629 | |||
| Nucleosomes (AU) | 0.35 | 0.60 | 0.2043 | 2.2473 |
| 0.2–1.1 | 0.3–1.8 | |||
| NT-proCNP (pmol/L) | 11.9 | 3.9 | 0.0399 | 0.4389 |
| 5.6–42.1 | 2.3–12.0 | |||
| PCT (pg/mL) | 99.6 | 93.5 | 0.7299 | 8.0289 |
| 40.3–182.9 | 54.7–208.1 | |||
| CCL2 (pg/mL) | 1274 | 249 | 0.0029 | 0.0319 |
| 282–2715 | 21–431 | |||
| CXCL8 (pg/mL) | 785.4 | 550.3 | 0.188 | 2.068 |
| 495.6–1857.0 | 51.8–1372.0 | |||
| IL-10 (pg/mL) | 8.5 | 8.5 | 0.008 | 0.088 |
| 8.5–106.4 | 8.5–8.5 | |||
| IL-6 (pg/mL) | 9.9 | 3.7 | 0.0680 | 0.748 |
| 3.7–1573.0 | 3.7–15.9 | |||
| KC-Like (pg/mL) | 164.1 | 20.3 | 0.0731 | 0.8041 |
| 8.0–1137.0 | 5.3–71.5 | |||
Median and IQR concentrations of measured biomarkers in blood in patients with SP and NSA, and results of univariate comparisons of biomarker concentrations between groups by Mann-Whitney U-test. Biomarkers identified to be significantly different in blood compared between SP and NSA groups after correction for multiple comparisons (P <0.05) are indicated in bold typeface. AU, arbitrary unit; CCL2, C-C Motif Chemokine Ligand-2; cfDNA, cell-free DNA; CXCL8, chemokine C-X-C motif ligand 8; IL, interleukin; IQR, interquartile range; KC-Like, keratinocyte chemoattractant-like; NSA, non-septic ascites; NT-proCNP, amino-terminal propeptide of C-type natriuretic peptide; Pcorr, P value corrected for multiple comparisons; PCT, procalcitonin; SP, septic peritonitis.
Table 3.
Comparisons of effusion biomarker concentrations in dogs with septic peritonitis (SP) and non-septic peritonitis (NSA).
| Effusion | ||||
|---|---|---|---|---|
| SP median IQR | NSA median IQR | P-value | Pcorr | |
| Glucose (mg/dL) | 20 | 94 | 0.011 | 0.121 |
| 20–108 | 78–99 | |||
| Glucose (mmol/L) | 1.1 | 5.2 | 0.011 | 0.121 |
| 1.1–6.0 | 4.3–5.5 | |||
| Lactate (mmol/L) | 7.9 | 1.8 | 0.0001 | 0.0011 |
| 2.7–11.3 | 1.1–2.8 | |||
| cfDNA (ng/mL) | 1085 | 470 | 0.0205 | 0.2255 |
| 493–2723 | 269–1157 | |||
| Nucleosomes (AU) | 13.1 | 2.5 | 0.0056 | 0.0616 |
| 4.4–25.1 | 0.3–12.9 | |||
| NT-proCNP (pmol/L) | 6.2 | 2.3 | 0.2806 | 3.0866 |
| 1.9–25.7 | 1.6–10.3 | |||
| PCT (pg/mL) | 38.4 | 98.9 | 0.0489 | 0.5379 |
| 0–119.2 | 29.7–201.6 | |||
| CCL2 (pg/mL) | 16066 | 683 | 0.0011 | 0.0121 |
| 2508–96300 | 449–2225 | |||
| CXCL8 (pg/mL) | 4325.0 | 129.6 | 0.0113 | 0.1243 |
| 21.7–75000.0 | 21.7–444.7 | |||
| IL-10 (pg/mL) | 303.1 | 8.5 | 0.0001 | 0.0011 |
| 147.6–1584.0 | 8.5–31.9 | |||
| IL-6 (pg/mL) | 2775.0 | 37.9 | 0.0011 | 0.0121 |
| 363.5–11495.0 | 3.7–1918.0 | |||
| KC-Like (pg/mL) | 1215.0 | 456.2 | 0.312 | 3.432 |
| 37.2–6973.0 | 62.1–757.0 | |||
Median and IQR concentrations of measured biomarkers in effusion in patients with SP and NSA, and results of univariate comparisons of biomarker concentrations between groups by Mann-Whitney U-test. Biomarkers identified to be significantly different in effusion compared between SP and NSA groups after correction for multiple comparisons (P <0.05) are indicated in bold typeface. AU, arbitrary unit; CCL2, C-C Motif Chemokine Ligand-2; cfDNA, cell-free DNA; CXCL8, chemokine C-X-C motif ligand 8; IL, interleukin; IQR, interquartile range; KC-Like, keratinocyte chemoattractant-like; NSA, non-septic ascites; NT-proCNP, amino-terminal propeptide of C-type natriuretic peptide; Pcorr, P value corrected for multiple comparisons; PCT, procalcitonin; SP, septic peritonitis.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.