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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Small. 2019 Mar 5;15(14):e1805526. doi: 10.1002/smll.201805526

Figure 8. Tissue assembly and function within the microelectronic scaffold.

Figure 8

A. Confocal microscope image showing the assembled cardiac tissue within the biomaterial–electronics hybrid. A large drug release electrode can be seen in the background. B. A Zoomed-in image of cardiac cells revealing cell elongation and massive striation. Sarcomeric actinin in pink, nuclei in blue. C. Extracellular potential recordings collected from an electrode within the tissue. D. Zoomed-in extracellular potential recording, showing a typical signal recorded from ventricular cardiomyocytes. E. Quantification of tissue contraction as a function of stimulation through the microelectronic device. The stimulation pattern is presented in the lower part.