Table 1.
Recombinant protein | Class | Plant | Pathology | Clinical trial status | Reference or company website |
---|---|---|---|---|---|
CaroRX™ | Antibody | Tobacco | Tooth decay | Approved as medical device | http://www.planetbiotechnology.com/ |
DoxoRX™ | Antibody | Tobacco | Side effects of cancer therapy | Phase I complete | http://www.planetbiotechnology.com/ |
RhinoRX™ | Tobacco | Rhinovirus prophylactic | Phase II | http://www.planetbiotechnology.com/ | |
Fv antibodies (38C13) | Antibody | Tobacco | Lymphoma | Phase I complete | http://www.lsbc.coma |
IgG (ICAM1) | Antibody | Tobacco | Common cold | Phase I | http://www.planetbiotechnology.com/ |
Antibody hepatitis B | Antibody | Tobacco | Hepatitis B | On market | [115] |
2 G12IgG1 | Antibody | Maize | HIV-1 | Phase I | http://www.pharma-planta.net/ |
Tobacco | |||||
Antitumor necrosis factor (Pr-anti-TNF) | Antibody | Carrot | Arthritis | Preclinical | http://www.protalix.com/ |
Anti-CD20 mAb (BLX-301) | Antibody | Duckweed | Lymphomas | Preclinical | http://www.biolex.com/ |
MAPP66 | Antibody | Tobacco | HSV/HIV microbicide | Phase I | http://www.bayer.com/ |
Avicidin® | Antibody | Maize | Colorectal cancer | Withdraw from phase II | |
IgA (HIgA-1) | Antibody | Soybean | HSV | Phase I | http://www.epicyte.com/ |
Cholera toxin B subunit (CTB) | Vaccine | Rice | Cholera | Phase I | [116, 117] |
LT-B | Vaccine | Maize | Diarrhea | Phase I | [118] |
Potato | Phase I | ||||
LT-B and TGEV glycoprotein S | Vaccine | Maize | Diarrhea and gastroenteritis | Phase I | [119] |
HBsAg | Vaccine | Lettuce | Hepatitis | Phase I | [120] |
Potato | [121] | ||||
HBsAg-env, gag epitopes of HIV-1 | Vaccine | Tomato | Hepatitis | [122] | |
Norwalk virus capsid protein (NVCP) | Vaccine | Potato | Gastroenteritis | Phase I | [123] |
Major capsid protein VP6 | Vaccine | Potato | Severe viral diarrhea | Preclinical | [124] |
HBsAg hepatitis B surface antigen, HSV herpes simplex virus, ICAM intercellular adhesion molecule, LT-B heat labile enterotoxin B subunit, mAb monoclonal antibody, TGEV transmissible gastroenteritis virus