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. 1980;8(2):70–72. doi: 10.1007/BF01639150

A two year serological surveillance of coronavirus infections in Hamburg

Eine serologische Untersuchung von Coronavirus-Infektionen in Hamburg über zwei Jahre

W Ehrengut 1, D E Sarateanu 1
PMCID: PMC7100827  PMID: 6248465

Summary

The occurrence of OC-43 coronavirus-like infections in the population of Hamburg was determined by a monthly serological survey (hemagglutination inhibition test [HI]) undertaken between October 1974 and October 1976. Studies of 3,016 sera revealed a high incidence of HI antibodies (58.2%). The frequency of seropositive reactions (=1:8) and the geometric mean titer were higher in individuals 15 to 24 years old. Treatment of 50 positive sera (titer 1:16 – 1:64) with receptor destroying enzyme, kaolin and ethacridin for elimination of nonspecific inhibitors did not modify the HI-titer of the investigated sera. The serological seasonal pattern suggests that coronaviruses are circulating the whole year in the urban population with a prevalence in the fall-winter period. Of the 331 paired sera examined, 6.6% presented a four- to eightfold rise in titer within eight weeks.

Keywords: Enzyme, Family Medicine, Kaolin, Seasonal Pattern, Urban Population

Literature

  • 1.Bradburne A. F., Bynoe M. L., Tyrrell D. A. J. Effects of a “new” respiratory virus in volunteers. Br. Med. J. 1967;3:767–769. doi: 10.1136/bmj.3.5568.767. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Tyrrel D. A. J., Bynoe M. L. Cultivation of a novel type of common-cold virus in organ cultures. Br. Med. J. 1965;1:1467–1470. doi: 10.1136/bmj.1.5448.1467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.McIntosh K., Dees J. H., Becker W. B., Kapikian A. Z., Chanock R. M. Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease. Proc. Natl. Acad. Sci. 1967;57:933–940. doi: 10.1073/pnas.57.4.933. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Kaye H. S., Dowdle W. R. Some characteristics of hemagglutination of certain strains of “IBV-like” virus. J. Infect. Dis. 1969;120:576–581. doi: 10.1093/infdis/120.5.576. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Sever J. L. Applications of a microtechnique to viral serological investigations. J. Immunol. 1962;88:320–329. [PubMed] [Google Scholar]
  • 6.U.S.A. Department of Health. Education and Welfare: Advanced laboratory techniques for influenza diagnosis. Public Health Service Atlanta 1975, p. 26.
  • 7.U.S.A. Department of Health, Education and Welfare: Laboratory diagnosis by serologic methods. Public Health Service Atlanta 1973, D-28.
  • 8.Heide K., Haupt H. Darstellung noch nicht therapeutisch angewandter Plasmaproteine. Behring-Werke Mitteilungen. 1964;43:161–192. [Google Scholar]
  • 9.Sarateanu D., Bronitki A., Popescu A., Teodosiu O., Isala G. Incidence of Coronavirus OC 43 antibodies among the population of Rumania. Rev. Roum. Virol. 1974;25:255–258. [PubMed] [Google Scholar]
  • 10.Sarateanu D. E., Ehrengut W. Serological study of coronavirus antibodies in Hamburg. Immun. Infekt. 1975;3:86–88. [PubMed] [Google Scholar]
  • 11.Sarateanu D. E., Ehrengut W. Jahreszeitliche Schwankungen von Koronavirusinfektionen in Hamburg. Immun. Infekt. 1976;4:141–143. [PubMed] [Google Scholar]
  • 12.Henigst W. Occurrence of antibody against coronavirus (OC43) in the healthy population and in patients with a disease of the respiratory tract. Zbl. Bakteriol. I. Abt. Orig. 1974;A 299:150–158. [PubMed] [Google Scholar]
  • 13.Monto A. S., Lim K. S. The Tecumseh study of respiratory illness. VI Frequency of and relationship between outbreaks of coronavirus infection. J. Infect. Dis. 1974;129:271–276. doi: 10.1093/infdis/129.3.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Riski H., Estola T. Occurrence of antibodies to human coronavirus OC43 in Finland. Scand. J. Infect. Dis. 1974;6:325–327. doi: 10.3109/inf.1974.6.issue-4.05. [DOI] [PubMed] [Google Scholar]
  • 15.Kaye H. S., Marsh H. B., Dowdle W. R. Seroepidemiologie survey of coronavirus (Strain OC 43) related infections in a children's population. Am. J. Epidemiol. 1971;94:43–49. doi: 10.1093/oxfordjournals.aje.a121293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.McIntosh K., Kapikian A. Z., Turner H. C., Hartley J. W., Parrott R. H., Chanock R. M. Seroepidemiologic studies of coronavirus infection in adults and children. Am. J. Epidemiol. 1970;91:585–592. doi: 10.1093/oxfordjournals.aje.a121171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Hamre D., Beem M. Virologic studies of acute respiratory disease in young adults. V. Coronavirus 229E infections during six years of surveillance. Am. J. Epidemiol. 1972;96:94–106. doi: 10.1093/oxfordjournals.aje.a121445. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Hendley J. O., Fishburne H. B., Gwaltney J. M., Jr. Coronavirus infections in working adults, eight-year study with 229E and OC43. Am. Rev. Respir. Dis. 1972;105:805–811. doi: 10.1164/arrd.1972.105.5.805. [DOI] [PubMed] [Google Scholar]
  • 19.Kapikian A. Z., James H. D., Jr., Kelly S. J., Dees J. H., Turner H. C., McIntosh K., Kim H. W., Parrott R. H., Vincent M. M., Chanock R. M. Isolation from man of “avian infectious bronchitis virus-like” viruses (coronaviruses) similar to 229E virus, with some epidemiological observations. J. Infect. Dis. 1969;119:282–290. doi: 10.1093/infdis/119.3.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20.Bradburne A. F., Somerset B. A. Coronavirus antibody titres in sera of healthy and experimentally infected volunteers. J. Hyg. 1972;70:235–244. doi: 10.1017/s0022172400022294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Bradburne A. F. Antigenic relationship amongst coronaviruses. Arch. ges. Virusforsch. 1970;31:352–364. doi: 10.1007/BF01253769. [DOI] [PMC free article] [PubMed] [Google Scholar]

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