Abstract
Research studies have highlighted both physiological and pathological evidence to incriminate surfactant abnormality and/or deficiency in many neonatal respiratory diseases. Data from animal models and clinical studies support the concept that surfactant replacement therapy (SRT) may have a role to play in such problems. There is now, therefore, a need to perform further randomized controlled trials to assess the appropriate clinical application of SRT in non-respiratory distress syndrome neonatal respiratory disease.
Key words: Surfactant replacement therapy, Neonatal respiratory disease
Abbreviations
- a/A
alveolar/arterial
- ARDS
adult respiratory distress syndrome
- CDH
congential diaphragmatic hernia
- ECMO
extracorporeal membrane oxygenation
- MAS
meconium aspiration syndrome
- RDS
respiratory distress syndrome
- SP-A
surfactant protein A
- SRT
surfactant replacement therapy
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