Intensive care support of patients after stem cell transplantation

C E Wrede; E Holler

doi:10.1007/s00390-007-0774-x

. 2007;44(3):129–141. [Article in German] doi: 10.1007/s00390-007-0774-x

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Intensive care support of patients after stem cell transplantation

C E Wrede ^1,^✉, E Holler ²

PMCID: PMC7102276 PMID: 32287638

Abstract

Within the hematologic therapy procedures, stem cell transplantation (SCT) represents the most extensive and invasive intervention. Those patients have certain risks for several bacterial, viral, as well as fungal infections during the different stages of transplantation. Especially in allogenic transplantation, discrimination of non-infectious, mostly immunologic complications like graft-versus-host reactions or VOD (veno-occlusive disease) is crucial, and often represents a therapeutic challenge. An adequate intensive care therapy of these patients can only be achieved with the knowledge of the specific complications of SCT. This review starts with an overview of the SCT stages with their corresponding infectious and noninfectious complications, followed by the discussion of organ specific pulmonary, renal, cardiac, gastrointestinal, hepatic and neurological complications of stem cell transplantation.

Key words: intensive care, stem cell transplantation, allogen, autolog, graft versus host

Footnotes

Serie: Die Notfall- und Intensivtherapie bei hämatologischen und onkologischen Erkrankungen Herausgegeben von E. Holler und C. Wrede (Regensburg)

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[CR3] 3.Afessa Crit Care Med. 2003;31:1715. doi: 10.1097/01.CCM.0000065761.51367.2D. [DOI] [PubMed] [Google Scholar]

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[CR7] 7.Almyroudis Transpl Infect Dis. 2005;7:11. doi: 10.1111/j.1399-3062.2005.00088.x. [DOI] [PubMed] [Google Scholar]

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[CR16] 16.Gratwohl Bone Marrow Transplant. 2006;37:1069. doi: 10.1038/sj.bmt.1705377. [DOI] [PubMed] [Google Scholar]

[CR17] 17.Grothaus-Pinke Transplantation. 2001;72:1456. doi: 10.1097/00007890-200110270-00022. [DOI] [PubMed] [Google Scholar]

[CR18] 18.Hale Biol Blood Marrow Transplant. 2003;9:698. doi: 10.1016/S1083-8791(03)00269-6. [DOI] [PubMed] [Google Scholar]

[CR19] 19.Heath Bone Marrow Transplant. 2006;37:523. doi: 10.1038/sj.bmt.1705280. [DOI] [PubMed] [Google Scholar]

[CR20] 20.Herbrecht N Engl J Med. 2002;347:408. doi: 10.1056/NEJMoa020191. [DOI] [PubMed] [Google Scholar]

[CR21] 21.Holler Curr Opin Hematol. 2002;9:479. doi: 10.1097/00062752-200211000-00002. [DOI] [PubMed] [Google Scholar]

[CR22] 22.Jones Transplantation. 1987;44:778. doi: 10.1097/00007890-198712000-00011. [DOI] [PubMed] [Google Scholar]

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[CR24] 24.Kessinger Bone Marrow Transplant. 1990;5:25. [PubMed] [Google Scholar]

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[CR33] 33.Nichols J Intensive Care Med. 2003;18:295. doi: 10.1177/0885066603258009. [DOI] [PubMed] [Google Scholar]

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[CR38] 38.Pihusch J Thromb Haemost. 2005;3:1935. doi: 10.1111/j.1538-7836.2005.01523.x. [DOI] [PubMed] [Google Scholar]

[CR39] 39.Pihusch Transplantation. 2005;80:1376. doi: 10.1097/01.tp.0000183288.67746.44. [DOI] [PubMed] [Google Scholar]

[CR40] 40.Richardson Blood. 2002;100:4337. doi: 10.1182/blood-2002-04-1216. [DOI] [PubMed] [Google Scholar]

[CR41] 41.Runde Bone Marrow Transplant. 2001;28:51. doi: 10.1038/sj.bmt.1703083. [DOI] [PubMed] [Google Scholar]

[CR42] 42.Saiz Semin Neurol. 2004;24:427. doi: 10.1055/s-2004-861537. [DOI] [PubMed] [Google Scholar]

[CR43] 43.Santo Tomas Chest. 2005;128:153. doi: 10.1378/chest.128.1.153. [DOI] [PubMed] [Google Scholar]

[CR44] 44.Schmitz Bone Marrow Transplant. 1998;21:995. doi: 10.1038/sj.bmt.1701234. [DOI] [PubMed] [Google Scholar]

[CR45] 45.Schulenburg Ann Hematol. 2004;83:101. doi: 10.1007/s00277-003-0756-4. [DOI] [PubMed] [Google Scholar]

[CR46] 46.Soubani Crit Care Med. 2006;34:S251. doi: 10.1097/01.CCM.0000231886.80470.B6. [DOI] [PubMed] [Google Scholar]

[CR47] 47.Soubani Chest. 2004;126:1604. doi: 10.1378/chest.126.5.1604. [DOI] [PubMed] [Google Scholar]

[CR48] 48.Zager Kidney Int. 1994;46:1443. doi: 10.1038/ki.1994.417. [DOI] [PubMed] [Google Scholar]

PERMALINK

Intensivmedizinische Betreuung von Patienten nach Stammzelltransplantation

Intensive care support of patients after stem cell transplantation

C E Wrede

E Holler

Zusammenfassung

Abstract

Footnotes

Literatur

ACTIONS

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PERMALINK

Intensivmedizinische Betreuung von Patienten nach Stammzelltransplantation

Intensive care support of patients after stem cell transplantation

C E Wrede

E Holler

Zusammenfassung

Abstract

Footnotes

Literatur

ACTIONS

PERMALINK

RESOURCES

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