Duplicates removed	40
Excluded at initial screening (e.g. press releases; news reports; not relevant drug/indication)	71
Excluded during initial selection (e.g. preclinical study; reviews; case reports; not randomized trials)	32
Excluded during writing (e.g. reviews; duplicate data; single-centre trials; phase I trials)	79
Cited efficacy/tolerability articles	19
Cited articles not efficacy/tolerability	20
Search Strategy: EMBASE, MEDLINE and PubMed from 1946 to present. Clinical trial registries/databases and websites were also searched for relevant data. Key words were Brentuximab, Adcetris, SGN-35, cAC10-vcMMAE, Hodgkin, CD30. Records were limited to those in English language. Searches last updated 2 February 2017