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. 1997;25(6):329–334. doi: 10.1007/BF01740811

Procalcitonin — A new indicator of the systemic response to severe infections

W Karzai 1, M Oberhoffer 1, A Meier-Hellmann 1, K Reinhart 1,
PMCID: PMC7102374  PMID: 9427049

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References

  • 1.Natanson C., Hoffmann W. D., Suffredini A., Eichacker P. Q., Danner R. L. Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann. Intern. Med. 1994;120:771–783. doi: 10.7326/0003-4819-120-9-199405010-00009. [DOI] [PubMed] [Google Scholar]
  • 2.Steinberg W, Tenner S. Acute pancreatitis. N. Engl. J. Med. 1994;330:1198–1205. doi: 10.1056/NEJM199404283301706. [DOI] [PubMed] [Google Scholar]
  • 3.Moore F. A., Haenel J. B., Moore E. E., Whitehill T. A. Incommensurate oxygen consumption in response to maximal oxygen availability predicts postinjury multiple organ failure. J. Trauma. 1992;33:58–67. doi: 10.1097/00005373-199207000-00012. [DOI] [PubMed] [Google Scholar]
  • 4.Saffle J. R., Sullivan J. J., Tuohig G. M., Larson C. M. Multiple organ failure in patients with thermal injury. Crit. Care Med. 1993;21:1673–1683. doi: 10.1097/00003246-199311000-00016. [DOI] [PubMed] [Google Scholar]
  • 5.Gramm H.-J., Reinhart K., Goecke J., v. Bülow J. Early clinical, laboratory, and hemodynamic indicators of sepsis and septic shock. In: Reinhart K., Eyrich K., editors. Sepsis — an interdisciplinary challenge. Berlin: Springer-Verlag; 1989. pp. 45–57. [Google Scholar]
  • 6.Le Moullec J. M., Jullienne A., Chenais J., Lasmoles F., Guilana J. M., Milhaud G., Moukhtar M. S. The complete sequence of preprocalcitonin. FEBS. 1984;167:93–97. doi: 10.1016/0014-5793(84)80839-x. [DOI] [PubMed] [Google Scholar]
  • 7.Jacobs J. W., Lund P. K., Potts J. T., Bell H. H., Habener J. F. Procalcitonin is a glycoprotein. J. Biol. Chem. 1981;256:2803–2807. [PubMed] [Google Scholar]
  • 8.Meisner M. PCT-procalcitonin. A new and innovative parameter in diagnosis of infections B.R.A.H.M.S. Berlin: Diagnostica; 1996. pp. 14–60. [Google Scholar]
  • 9.Assicot M., Gendrel D., Carsin H., Raymond J., Guilbaud J., Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet. 1993;341:515–518. doi: 10.1016/0140-6736(93)90277-N. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Oberhoffer M., Vogelsang H., Meier-Hellmann A., Jäger L., Reinhart K. Antikatacalcin-antibody reaction in different types of human leukocytes indicates procalcitonin content. Shock. 1997;7:123. [Google Scholar]
  • 11.Nylen E. S., Snider R. H., Thompson K. A., Rohatgi P., Becker K. L. Pneumonitis-associated hypercalcitoninemia. Am. J. Med. Sci. 1996;312:12–18. doi: 10.1097/00000441-199607000-00003. [DOI] [PubMed] [Google Scholar]
  • 12.Becker K. L., O'Neill W., Snider R. H., Nylen E. S., Jeng J., Silva O. L., Lewis M. S., Jordan M. H. Hypercalcitoninemia in inhalation burn injury: a response of the pulmonary neuroendocrine cell? Anat. Rec. 1993;236:136–138. doi: 10.1002/ar.1092360118. [DOI] [PubMed] [Google Scholar]
  • 13.Cate C. C., Pettingill O. S., Sorensen G. D. Biosynthesis of procalcitonin in small cell carcinoma of the lung. Cancer Res. 1986;46:812–818. [PubMed] [Google Scholar]
  • 14.Mallet E., Lanse X., Devaux A. M., Ensel P., Basuyau J. P., Brunelle P. Hypercalcitoninemia in fulminant meningococcaemia in children. Lancet. 1983;i:294. doi: 10.1016/s0140-6736(83)91704-x. [DOI] [PubMed] [Google Scholar]
  • 15.Gendrel D., Bohuon C. Procalcitonin, a marker of bacterial infection. Infection. 1997;25:133–134. doi: 10.1007/BF02113598. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Leser H.-G., Gross V., Scheibenbogen C., Heinisch A., Salm R., Lausen M., Rückauer K., Farthmann E. H., Schölmerich J. Elevation of serum interleukin-6 concentration precedes acute phase response and reflects severity in acute pancreatitis. Gastroenterology. 1991;101:782–785. doi: 10.1016/0016-5085(91)90539-w. [DOI] [PubMed] [Google Scholar]
  • 17.Kragsberbjer P., Holmberg H., Vikefors T. Serum concentrations of interleukin-6, tumor necrosis factor-alpha, and C-reactive protein in patients undergoing major operations. Eur. J. Surg. 1995;161:17–22. [PubMed] [Google Scholar]
  • 18.Dandona P., Nix D., Wilson M. F., Aljada A., Love J., Assicot M., Bohuon C. Procalcitonin increase after endotoxin injection in normal subjects. J. Clin. Endocrinol. Metab. 1994;79:1605–1608. doi: 10.1210/jcem.79.6.7989463. [DOI] [PubMed] [Google Scholar]
  • 19.Brunkhorst F. M., Forycki Z. F., Wagner J. Release and kinetics of procalcitonin (PCT) after gram-negative bacterial infection in a healthy subject. Shock. 1997;7:124. [Google Scholar]
  • 20.Bîgel D. Procalcitonin vs immunological markers in infection/inflammation. Br. J. Anaesth. 1996;76:A352. [Google Scholar]
  • 21.Brunkhorst F. M., Forycki Z. F., Wagner J. Identification of immuneactivation of infectious origin by procalcitonin-immunoreactivity in different body fluids. Clin. Intensive Care. 1996;7:41. [Google Scholar]
  • 22.Gramm H.-J., Dollinger P., Beier W. Procalcitonin — a new marker of host inflammatory response. Longitudinal studies in patients with sepsis and peritonitis (translated from the German) Chir. Gastroenterol. 1995;11(Suppl. 2):51–54. [Google Scholar]
  • 23.De Werra I., Jaccard C., Corradin S. B., Chiolero R., Yersin B., Gallati H., Assicot M., Bohuon C., Baumgartner J.-D., Glauser M. P., Heumann D. Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations: Comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia. Crit. Care Med. 1997;25:607–613. doi: 10.1097/00003246-199704000-00009. [DOI] [PubMed] [Google Scholar]
  • 24.Rau, B., Steinbach, G., Gansauge, F., Mayer, J. M., Grünert, A., Beger, H. G.: The role of procalcitonin and interleukin-8 in the prediction of infected necrosis in acute pancreatitis. Gut (1997) (in press). [DOI] [PMC free article] [PubMed]
  • 25.Eberhard O. K., Haubitz M., Brunkhorst F. M., Kliem V., Koch K. M., Brunkhorst R. Usefulness of procalcitonin for differentiation between activity of systemic autoimmune disease (systemic lupus erythematoles, systemic antineutrophil cytoplasmic antibody associated vasculitis) and invasive bacterial infection. Arthritis Rheum. 1997;40:1250–1256. doi: 10.1002/1529-0131(199707)40:7<1250::AID-ART9>3.0.CO;2-A. [DOI] [PubMed] [Google Scholar]
  • 26.Oberhoffer M., Bitterlich A., Hentschel T., Meier-Hellmann A., Vogelsang H., Reinhart K. Procalcitonin (ProCt) correlates better with the ACCP/SCCM consensus conference definitions than other specific markers of the inflammatory response. Clin. Intensive Care. 1996;7:46. [Google Scholar]
  • 27.Al-Nawas B., Krammer I., Shah P. M. Procalcitonin in the diagnosis of severe infections. Eur. J. Med. Res. 1996;1:331–333. [PubMed] [Google Scholar]
  • 28.Reith, H. B., Mittelkötter, U., Kamen, S., Beier, W., Dohle, J., Kozuschek, W.: Procalcitonin — a parameter for the diagnosis of septic course? (translated from the German). Langenb. Arch. Chir. (1997) (in press).
  • 29.Gendrel, D., Raymond, J., Assicot, M., Moulin, F., Bergeret, M., Badoual, J., Bohuon, C.: Procalcitonin in bacterial and viral meningitis in children. Abstr. volume of ICAC, 20 September 1995 (1995) (abstr.).
  • 30.Gerard Y., Hober D., Assicot M., Alfandari S., Ajana F., Bourez J. M., Chidiac C., Mouton Y., Bohuon C., Wattre P. Procalcitonin as a marker of bacterial sepsis in patients infected with HIV 1. J. Infect. 1997;35:41–46. doi: 10.1016/s0163-4453(97)90953-1. [DOI] [PubMed] [Google Scholar]
  • 31.Brunkhorst F. M., Forycki Z. F., Wagner J. Frühe Indentifikation der biliären akuten Pankreatitis durch Procalcitonin-Immunreaktivität — vorläufige Ergebnisse (Early identification of acute biliary pancreatitis with procalcitonin immunoreactivity — preliminary results) Chir. Gastroenterol. 1995;11:S47–S50. [Google Scholar]
  • 32.Gerard Y., Hober D., Petitjean S., Assicot M., Bohuon C., Mouton Y., Wattre P. High serum procalcitonin level in a 4-year-old liver transplant recipient with a disseminated candidiasis (letter) Infection. 1995;23:310–311. doi: 10.1007/BF01716295. [DOI] [PubMed] [Google Scholar]
  • 33.Staehler M., Hammer C., Meiser B., Reichart B. Procalcitonin: a new marker for differential diagnosis of acute rejection and bacterial infection in heart transplantation. Transplant. Proc. 1997;29:584–585. doi: 10.1016/s0041-1345(96)00314-4. [DOI] [PubMed] [Google Scholar]
  • 34.Smith M. D., Suputtamongkol Y., Chaowagul W., Assicot M., Bohuon C., Petitjean S., White N. J. Elevated serum procalcitonin levels in patients with melioidosis. Clin. Infect. Dis. 1995;20:641–645. doi: 10.1093/clinids/20.3.641. [DOI] [PubMed] [Google Scholar]
  • 35.Bögel D. Procalcitonin is higher in non-survivors during course of sepsis, severe sepsis, and septic shock. Intensive Care Med. 1996;22:A245. [Google Scholar]
  • 36.Smith R. P., Lipworth B. J. C-reactive protein in simple community acquired pneumonia. Chest. 1995;107:1028–1031. doi: 10.1378/chest.107.4.1028. [DOI] [PubMed] [Google Scholar]
  • 37.Erikson S., Grantström L., Olander B., Wretlind B. Sensitivity of interleukin-6 and C-reactive protein concentrations in the diagnosis of acute appendicitis. Eur. J. Surg. 1995;161:41–45. [PubMed] [Google Scholar]
  • 38.Chwals W. J., Fernandez M. E., Jamie A. C., Charles B. J., Rushing J. T. Detection of postoperative sepsis in infants with the use of metabolic stress monitoring. Arch. Surg. 1994;129:437–442. doi: 10.1001/archsurg.1994.01420280115015. [DOI] [PubMed] [Google Scholar]
  • 39.Shaw A. C. Serum C-reactive protein and neopterin concentrations in patients with viral or bacterial infection. J. Clin. Pathol. 1991;44:596–599. doi: 10.1136/jcp.44.7.596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 40.Monneret G., Labaune J. M., Isaac C., Bienvenu F., Putet G., Bienvenu J. Procalcitonin and C-reactive protein levels in neonatal infections. Acta Paediatr. 1997;86:209–212. doi: 10.1111/j.1651-2227.1997.tb08870.x. [DOI] [PubMed] [Google Scholar]
  • 41.Gramm, H.-J., Zimmermann, J., Quedra, N., Wegscheider, K.: The procalcitonin (PROCT) response in severe sepsis is closely correlated to cytokine kinetics. Shock 7 (1997) A489 (abstr.).
  • 42.Marnitz R., Gramm H.-J., Zimmermann J. Elaboration of mediators of inflammatory response after major surgery. Shock. 1997;7:124. [Google Scholar]
  • 43.Meisner M., Tschaikowsky K., Schmidt J., Schüttler J. Procalcitonin (PCT) — indications for a new diagnostic parameter of severe bacterial infection and sepsis in transplantation, immunosuppression, and cardiac assist devices. Cardiovasc. Eng. 1996;1:67–76. [Google Scholar]
  • 44.Bertagna X. Y., Nicholson W. E., Pettengill O. S., Sorensen G. D., Mount C. D., Orth D. N. Ectopic production of high molecular weight calcitonin and corticotropin by human small cell carcinoma cells in tissue culture: evidence for separate precursors. J. Clin. Endocrinol. Metab. 1978;47:1390–1393. doi: 10.1210/jcem-47-6-1390. [DOI] [PubMed] [Google Scholar]
  • 45.Raue F., Blind E., Grauer A. PDN-21 (katacalcin) and chromogranin A: tumor markers for medullary thyroid carcinoma. Henry Ford Hosp. Med. J. 1992;40:296–298. [PubMed] [Google Scholar]
  • 46.Pilz G., Kreuzer E., Appel R., Werdan K. Procalcitonin (PCT) serum levels in the early postoperative [period] of cardiac surgical patients at high risk for sepsis. Shock. 1997;7:124. [Google Scholar]

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