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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Gastroenterology. 2019 Dec 19;158(5):1274–1286.e12. doi: 10.1053/j.gastro.2019.12.012

Table 4:

Risk estimates for early-onset versus late-onset CRC associated with a 95-SNP PRS in the RPGEH replication cohorta

PRS N in eligible cohort N (cases) HR (95% CI) P value P value for interactionb
All Subjects 0.3291
<50 Years-Old per 1 SD 26983 25 1.73 (1.17, 2.56) 0.0056
≥50 Years-Old per 1 SD 67792 1068 1.43 (1.34, 1.51) 2.77E-31
Negative Family History 0.3681
<50 Years-Old per 1 SD 24472 18 1.76 (1.11, 2.78) 0.0161
≥50 Years-Old per 1 SD 61129 871 1.42 (1.33, 1.52) 2.85E-25
Positive Family History 0.6920
<50 Years-Old per 1 SD 2511 7 1.56 (0.75, 3.26) 0.2334
≥50 Years-Old per 1 SD 6668 202 1.34 (1.17, 1.54) 2.87E-05
a

The Cox models include sex, principal components, and polygenic risk score.

b

P value produced from interaction term with continuous PRS (per SD) and age (<50 versus ≥50 years).