Abstract
Synthesis of amino acid conjugates of glycyrrhizic acid with the use of N-hydroxyphthalimide, N,N'-dicyclohexylcarbodiimide, and tert-butyl esters of L-amino acids (valine, isoleucine, phenylalanine, and methionine) was performed followed by deprotection with trifluoroacetic acid. The target amino acid conjugates were isolated by column chromatography on silica gel in 40–45% yield. The structure of the prepared compounds was confirmed by IR and 13C NMR spectroscopy.
Keywords: glycyrrhizic acid; amino acids tert-butyl esters; conjugates; N-hydroxyphthalimide; N,N-dicyclohexylcarbodiimide
Footnotes
Original Russian Text © L.A. Baltina, Jr., A.I. Fairushina, L.A. Baltina, 2015, published in Zhurnal Obshchei Khimii, 2015, Vol. 85, No. 12, pp. 2003–2006.
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