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. 2004 Mar 23;80(2):258–260. doi: 10.1016/0035-9203(86)90030-1

Inhibition in vivo of both infective Leishmania major and L. mexicana amazonensis mediated by a single monoclonal antibody

MC Debons-Guillemin 1, I Vouldoukis 2, A Roseto 1, C Alfred 2, C Chopin 1, I Ploton 2, L Monjour 2
PMCID: PMC7107255  PMID: 3787687

Abstract

Monoclonal antibodies raised against a strain of Leishmania infantum isolated in Greece were produced and tested for their protective effect in an in vivo system (in BALB/C mice). A single monoclonal antibody, IgG2b isotype, can prevent the development of two Leishmania strains in vivo: one of L. major and one of L. mexicana amazonensis. This antibody-mediated protection may be dependent on complement.

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