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. 2004 Jul;21(7):1462. doi: 10.1093/molbev/msh172

A Large Variation in the Rates of Synonymous Substitution for RNA Viruses and Its Relationship to a Diversity of Viral Infection and Transmission Modes

PMCID: PMC7107538

DOI:10.1093/molbev/msh172

Kousuke Hanada, Yoshiyuki Suzuki, and Takashi Gojobori Mol. Biol. Evol. 21:1074–1080. 2004

Table 2 of this article should have appeared as it does below. The publisher regrets the error.

Table 2.

Synonymous Substitution Rates for RNA Viruses.

Virus Species Synonymous Substitution Rate Natural Host (Transmission Mode) Acute Infection Persistent Infection Latent Infection
Enterovirus
Human enterovirus A 1.00 × 10−2, (0.99–2.01) × 10−2 Human (fecal-oral route)
    Human enterovirus B 3.65 × 10−3, (3.60–7.82) × 10−3 Human (fecal-oral route)
    Human poliovirus 2.56 × 10−2, (2.56–2.57) × 10−2 Human (fecal-oral route)
Swine vesicular disease virus 2.95 × 10−3, (2.85–8.65) × 10−3 Pig (fecal-oral route)
Hepatovirus
    Human hepatitis A virus 1.30 × 10−3, (1.27–1.33) × 10−3 Human (fecal-oral route)
Togaviridae
Alphavirus
Eastern equine encephalitis virus 3.25 × 10−4, (3.03–3.51) × 10−4 Birds (via vector [tick])
Rubivirus
    Rubella virus 2.64 × 10−3, (2.63–2.65) × 10−3 Human (aerosol infection)
Coronaviridae
Coronavirus
    Bovine coronavirus 1.20 × 10−3, (1.13–1.43) × 10−3 Cattle (aerosol infection)
Arteriviridae
Arterivirus
Porcine reproductive and respiratory syndrome virus 6.21 × 10−2, (6.01–7.81) × 10−2 Pig (aerosol infection)
    Equine arteritis virus 5.20 × 10−3, (4.80–7.20) × 10−3 Horse (aerosol infection)
Negative stranded ss RNA viruses
Arenaviridae
Arenavirus
    Junin virus* 5.06 × 10−3, (5.02–5.10) × 10−3 Rodents (fecal-oral route)
Bunyaviridae
Hantavirus
    Puumala virus 5.21 × 10−5, (5.19–7.30) × 10−5 Rodents (fecal-oral route)
Nairovirus
Crimean-Congo hemorrhagic fever virus 1.23 × 10−3, (1.23–1.24) × 10−3 Human (via vector [tick])

* Junin virus induces a latent infection in rodents. However, the virus does not induce such the infection mode in human. In fact, the data used here were the data of the virus strains isolated from human. Therefore, the infectious mode was used for human.


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