TABLE 2.
Genes on the array identified as calcium channels, calcium transporters, or calcium-binding proteins that were expressed at any level in the mouse mammary gland
| Gene | Protein | Virgin | Pregnant | Lactating | Involuting |
|---|---|---|---|---|---|
| Ca-ATPases | |||||
| PMCAs | |||||
| Atp2b2 | PMCA2 | 1 | 1.56 ± 0.17 | 62.95 ± 6.58 | 1.40 ± 0.17 |
| SERCAs | |||||
| Atp2a1 | SERCA1 | 1 | 2.60 ± 0.95 | 0.73 ± 0.10 | 0.89 ± 0.21 |
| Atp2a2 | SERCA2 | 1 | 0.46 ± 0.03 | 0.68 ± 0.10 | 0.38 ± 0.02 |
| Atp2a3 | SERCA3 | 1 | 1.20 ± 0.03 | 1.51 ± 0.03 | 1.27 ± 0.06 |
| Calcium channels | |||||
| Voltage-dependent channels | |||||
| Cacna1a | α1-a subunit | 1 | 1.11 ± 0.02 | 1.39 ± 0.09 | 1.14 ± 0.03 |
| Cacna1b | α1-b subunit | 1 | 1.16 ± 0.02 | 1.40 ± 0.03 | 1.19 ± 0.03 |
| Cacna1c | α1-c subunit | 1 | 0.81 ± 0.04 | 1.26 ± 0.09 | 0.96 ± 0.10 |
| Cacna1e | α1-e subunit | 1 | 1.17 ± 0.04 | 1.53 ± 0.05 | 1.27 ± 0.05 |
| Cacna1g | α1-g subunit | 1 | 1.07 ± 0.04 | 1.49 ± 0.07 | 1.13 ± 0.08 |
| Cacna1 h | α1-h subunit | 1 | 1.23 ± 0.05 | 1.64 ± 0.13 | 1.23 ± 0.05 |
| Cacna1s | α1-s subunit | 1 | 1.23 ± 0.02 | 1.65 ± 0.08 | 1.32 ± 0.05 |
| Cacna2d1 | α2-δ subunit 1 | 1 | 1.24 ± 0.12 | 1.58 ± 0.05 | 1.23 ± 0.08 |
| Cacna2d3 | α2-δ subunit 3 | 1 | 1.50 ± 0.07 | 2.44 ± 0.13 | 1.65 ± 0.09 |
| Cacnb2 | β2-subunit | 1 | 1.12 ± 0.03 | 1.43 ± 0.03 | 1.20 ± 0.07 |
| Cacng2 | γ2 subunit | 1 | 1.44 ± 0.07 | 2.17 ± 0.46 | 1.47 ± 0.11 |
| Transient receptor potential channels | |||||
| Trpc1 | 1 | 1.28 ± 0.03 | 1.71 ± 0.09 | 1.36 ± 0.07 | |
| Trpc4 | 1 | 1.37 ± 0.05 | 1.84 ± 0.07 | 1.54 ± 0.17 | |
| Trpc5 | 1 | 1.31 ± 0.04 | 1.87 ± 0.09 | 1.42 ± 0.10 | |
| Trpc6 | 1 | 1.57 ± 0.08 | 2.80 ± 0.20 | 1.81 ± 0.22 | |
| Trpv2 | 1 | 0.27 ± 0.02 | 0.33 ± 0.02 | 0.28 ± 0.02 | |
| Intracellular calcium release | |||||
| Inositol 1,4,5-triphosphate receptors | |||||
| Itpr1 | 1 | 0.77 ± 0.05 | 0.90 ± 0.05 | 1.01 ± 0.20 | |
| Itpr2 | 1 | 0.29 ± 0.04 | 0.06 ± 0.00 | 0.71 ± 0.07 | |
| Itpr5 | 1 | 1.11 ± 0.03 | 1.51 ± 0.06 | 1.21 ± 0.07 | |
| Ryanodine receptors | |||||
| Ryr1 | 1 | 0.20 ± 0.00 | 0.26 ± 0.01 | 0.22 ± 0.01 | |
| Ryr2 | 1 | 1.10 ± 0.02 | 1.45 ± 0.06 | 1.15 ± 0.04 | |
| Ryr3 | 1 | 1.13 ± 0.05 | 1.75 ± 0.08 | 1.30 ± 0.13 | |
| Calcium-binding proteins | |||||
| Calmodulins | |||||
| Calm1 | Calmodulin 1 | 1 | 0.66 ± 0.02 | 0.38 ± 0.04 | 0.55 ± 0.05 |
| Calm2 | Calmodulin 2 | 1 | 1.28 ± 0.02 | 0.50 ± 0.04 | 1.20 ± 0.02 |
| Calm3 | Calmodulin 3 | 1 | 1.13 ± 0.10 | 0.53 ± 0.13 | 0.87 ± 0.01 |
| Calm4 | Calmodulin 4 | 1 | 1.06 ± 0.03 | 1.56 ± 0.13 | 1.10 ± 0.04 |
| Calml4 | Calmodulin-like 4 | 1 | 0.28 ± 0.01 | 0.37 ± 0.01 | 0.32 ± 0.02 |
| Calbindins | |||||
| Calb1 | Calbindin 1 | 1 | 1.11 ± 0.04 | 1.59 ± 0.07 | 1.19 ± 0.07 |
| Calb2 | Calbindin 2 | 1 | 1.10 ± 0.02 | 1.35 ± 0.02 | 1.17 ± 0.04 |
| Nucleobindins | |||||
| Nucb1 | Nucleobindin 1 | 1 | 0.50 ± 0.06 | 0.10 ± 0.01 | 0.13 ± 0.01 |
| Nucb2 | Nucleobindin 2 | 1 | 3.05 ± 0.36 | 8.14 ± 1.67 | 14.42 ± 1.48 |
| Calreticulins | |||||
| Calr | Calreticulin | 1 | 1.13 ± 0.04 | 1.52 ± 0.06 | 1.18 ± 0.05 |
| Calr4 | Calreticulin 4 | 1 | 1.10 ± 0.03 | 1.86 ± 0.11 | 1.22 ± 0.07 |
| S100 proteins | |||||
| S100a1 | 1 | 0.63 ± 0.08 | 0.19 ± 0.02 | 0.76 ± 0.06 | |
| S100a3 | 1 | 1.68 ± 0.12 | 3.72 ± 0.32 | 2.00 ± 0.23 | |
| S100a4 | 1 | 0.39 ± 0.02 | 0.26 ± 0.04 | 0.32 ± 0.02 | |
| S100a6 | 1 | 0.23 ± 0.04 | 0.08 ± 0.01 | 0.30 ± 0.07 | |
| S100a8 | 1 | 0.71 ± 0.07 | 0.71 ± 0.03 | 0.80 ± 0.18 | |
| S100a9 | 1 | 1.12 ± 0.07 | 1.40 ± 0.05 | 1.20 ± 0.09 | |
| S100a10 | 1 | 0.45 ± 0.05 | 0.06 ± 0.01 | 0.44 ± 0.06 | |
| S100a11 | 1 | 0.44 ± 0.06 | 0.06 ± 0.01 | 1.07 ± 0.05 | |
| S100a13 | 1 | 0.67 ± 0.07 | 0.20 ± 0.03 | 0.71 ± 0.05 | |
| S100pbp | 1 | 0.86 ± 0.06 | 1.01 ± 0.06 | 0.95 ± 0.07 | |
| Other | |||||
| Rcvrn | Recoverin | 1 | 1.12 ± 0.03 | 1.50 ± 0.04 | 1.21 ± 0.07 |
| Anxa6 | Annexin A6 | 1 | 0.74 ± 0.07 | 0.68 ± 0.03 | 0.84 ± 0.07 |
Expression levels are given relative to the virgin mammary gland samples.