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. 2019 Jun 27;105(4):895–904. doi: 10.3324/haematol.2018.202010

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Figure 4. — Adjustable biophysical parameters influence simulated cell migration in the bone marrow. Simulation of cell migration in bone marrow was performed with adjustable parameters: cell type, bone marrow crowdedness, cell velocity, chemotaxis and vessel stickiness. (A) Number of steps until entering the vessel lumen for artificial hematopoietic stem cells (HSC; black) and neutrophils (magenta) migrating in the bone marrow with or without increased crowdedness resulting from the presence of megakaryocytes at high and low instantaneous velocities of V_high = 3 ± 2 μm/step and V_low = 2 ± 1 μm/step, respectively. The probability of entering the vessel lumen after contact (P_EV) was set at P_EV = 100% and chemotaxis was absent (C = 0). (B-D) Mean squared displacement (MSD) and neutrophil trajectories for the megakaryocyte-free template at high velocities (B) and a megakaryocyte-containing simulation environment at high (C) and low (D) velocities. P_EV = 100% and C = 0. (E) Number of steps until entering the vessel lumen for P_EV = 100% and P_EV = 50% for increasing chemotaxis (C = 0; 0.1; 0.2; 0.4) in the presence of megakaryocytes. (F-G) MSD analysis of neutrophil and HSC migration data from (E) for P_EV = 50% and C = 0. Six hundred simulations were performed for each simulation type. Plots for HSC migration are shown in Online Supplementary Figure S7.