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. 2019 Jul 11;105(4):1032–1041. doi: 10.3324/haematol.2018.211904

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Figure 6. — Daratumumab combined with R-CHOP in a patient-derived diffuse large B-cell lymphoma xenograft model. Fragments from a patient-derived diffuse large B-cell lymphoma (DLBCL) were injected subcutaneously into SCID mice (n=8-10) and staged to approximately 150-250 mm³ mean tumor volume to measure (A) tumor growth and (B) overall survival (OS). 20 mg/kg daratumumab was administered weekly alone or in combination with CHOP (20 mg/kg cyclophosphamide, 1.25 mg/kg doxorubicin, 0.2 mg/kg vincristine, and 0.15 mg/kg prednisone) or R-CHOP (10 mg/kg rituximab+ CHOP) for a total of three weeks.