RÉSUMÉ
On connaît plus de 1 240 espèces de chauves-souris ; beaucoup sont insectivores, d’autres frugivores et quelques espèces américaines sont hématophages. Ces mammifères peuvent héberger plus de 100 virus différents, en particulier des Rhabdoviridae (des Lyssavirus, dont le virus rabique), des Paramyxoviridae (comme les virus Nipah et Hendra), des Filoviridae (virus Ebola et Marburg) et des Coronaviridae (agents du SRAS et du MERS). Ces infections sont généralement asymptomatiques chez les chauves-souris mais le mécanisme de cette tolérance n’est pas encore bien compris. Quoi qu’il en soit, les chauves-souris apparaissent pour ces virus comme des réservoirs et des disséminateurs efficaces ; elles représentent donc un risque important en santé publique humaine et vétérinaire, justifiant la mise en place d’une surveillance spécifique et de programmes de recherche portant notamment sur les mécanismes de l’immunité propres à ces animaux.
SUMMARY
More than 1 240 species of bats are known ; many of them are insectivorous, others are frugivorous and some american species are haematophagous. More than 100 different viruses are associated with these mammals, particularly Rhabdoviridae (Lyssavirus like rabies virus), Paramyxoviridae (like Nipah and Hendra viruses), Filoviridae (Ebola and Marburg viruses) and Coronaviridae (viruses causing SARS and MERS). These infections are usually asymptomatic in bats but the mechanism of this tolerance is not yet understood. For those viruses, bats are efficient reservoirs and disseminators. So, they represent a significative risk for human and animal public health, that justifies to set up surveillance of batassociated viruses and research programs about the particular immunity mechanisms of bats.
Mots-clés: Chiroptères, Virus, Tolérance immunitaire, Réservoir, Épidémiologie
Key-words: Chiroptera, Virus, Immune tolerance, Reservoir, Epidemiology
Footnotes
L’auteur déclare ne pas avoir de lien d’intérêt en relation avec le contenu de cet article
Tirés à part : Professeur François Rodhain.
RÉFÉRENCES
- 1.Calisher C.H., Childs J.E., Field H.E., Holmes K.V., Schnountz T. Bats: Important Reservoir Hosts of Emerging Viruses. Clin Microbiol Rev. 2006;19(3):531–545. doi: 10.1128/CMR.00017-06. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Van der Poel W.H.M., Lina P.H.C., Kramps J.A. Public Health Awareness of emerging zoonotic Viruses of Bats: a European Perspective. Vector-borne Zoonotic Dis. 2006;6:315–324. doi: 10.1089/vbz.2006.6.315. [DOI] [PubMed] [Google Scholar]
- 3.Picard-Meyer E., Robardet E., Arthur L., Larcher G., Harbusch C., Servat A., Cliquet F. Bat Rabies in France: a 24-year Retrospective epidemiological Study. PLoS ONE. 2014;9(6) doi: 10.1371/journal.pone.0098622. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Nadin-Davis S.A., Real L.A. Molecular Phylogenetics of the Lyssaviruses. Insights from a coalescent approach. Adv Virus Res. 2011;79:203–238. doi: 10.1016/B978-0-12-387040-7.00011-1. [DOI] [PubMed] [Google Scholar]
- 5.Shankar V., Orciari L.A., Mattos C.D., Kuzmin I.V., Pape W.J., O’Shea T.J., Rupprecht C.E. Genetic divergence of rabies viruses from bat species of Colorado. USA. Vector-borne Zoon Dis. 2005;5:330–341. doi: 10.1089/vbz.2005.5.330. [DOI] [PubMed] [Google Scholar]
- 6.Hahn M.B., Gurley E.S., Epstein J.H., Islam M.S., Patz J.A., Daszak P., Luby S.P. The Role of Landscape composition and configuration on Pteropus giganteus Roosting Ecology and Nipah virus spillover Risk in Bangladesh. Am J Trop Med Hyg. 2014;90:247–255. doi: 10.4269/ajtmh.13-0256. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Daszak P., Zambrana-Torrelio C., Bogich T.L., Fernandez M., Epstein J.H., Murray K.A., Hamilton H. Interdisciplinary approaches to understanding disease emergence: the past, present and future drivers of Nipah virus emergence. Proc Nat Acad Sci. 2013;110:3681–3688. doi: 10.1073/pnas.1201243109. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Drexler J.F., Corman V.M., Müller M.A., Maganga G.D., Vallo P., Gloza-Rausch F., Cottontail V.M., Rasche A., Yordanov S., Seebens A. Bats host major mammalian paramyxoviruses. Nature Communications. 2012;3:796. doi: 10.1038/ncomms1796. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 9.Towner J.S., Pourrut X., Albarino C.G., Nkogue C.N., Bird B.H., Grard G., Ksiazek T.G., Gonzalez J.P., Nichol S.T., Leroy E.M. Marburg Virus Infection detected in a common African Bat. PLOS One. 2007 doi: 10.1371/journal.pone.0000764. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Moutou F. La vengeance de la civette masquée. 2007:336. Editions Le Pommier, Paris. [Google Scholar]
- 11.Li W., Shi Z., Yu M., Ren W., Smith C., Epstein J.H., Wang H., Crameri G., Hu Z. Bats are natural reservoirs of SARS-like coronaviruses. Science. 2005;310:676–679. doi: 10.1126/science.1118391. [DOI] [PubMed] [Google Scholar]
- 12.Vabret A., Pillet S., Enouf V. Un nouveau coronavirus venu du Moyen-Orient. Virologie. 2013;17:211–215. doi: 10.1684/vir.2013.0514. [DOI] [PubMed] [Google Scholar]
- 13.Memish Z.A., Mishra N., Olival K.J. Middle East respiratory syndrome Coronavirus in Bats. Saudi Arabia. Emerg Infect Dis. 2013;19:1819–1823. doi: 10.3201/eid1911.131172. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.O’Shea T.J., Cryan P.M., Cunningham A.A., Fooks A.R., Hayman D.T.S., Luis A.D., Peel A.J., Plowright R.K., Wood L.N. Bat Flight and Zoonotic Viruses. Emerg Infect Dis. 2014;20:741–745. doi: 10.3201/eid2005.130539. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M. Comparative Analysis of Bat Genomes provides Insight into the Evolution of Flight and Immunity. Science. 2013;339:56–60. doi: 10.1126/science.1230835. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Blackwood J.C., Streicker D.G., Altizer S., Rohani P. Resolving the roles of immunity, pathogenesis and immigration for rabies persistence in vampire bats. Proc Nat Acad Sciences. 2013;110(51):20837–20842. doi: 10.1073/pnas.1308817110. [DOI] [PMC free article] [PubMed] [Google Scholar]