Abstract
In this paper, we report a multiple sequence alignment result on the basis of 10 amino acid sequences of the M protein, which come from different coronaviruses (4 SARS-associated and 6 others known). The alignment model was based on the profile HMM (Hidden Markov Model), and the model training was implemented through the SAHMM (Self-Adapting Hidden Markov Model) software developed by the authors.
Key words: SARS (Severe Acute Respiratory Syndrome); corona virus; M (Membrane or Matrix) protein; multiple sequence alignment, profile HMM
MAC 2000: 60J20, 92C40
Footnotes
Project supported by the National Natural Science Foundation of China (Grant No. 70171059) and the 863 Project (Grant No. 2002AA234021)
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