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. 2014 Aug 1;464:196–205. doi: 10.1016/j.virol.2014.06.040

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Copyright © 2014 Elsevier Inc. All rights reserved.

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Fig. 5 — Validation of histone acetyltransferase (HAT) and histone deacetylase (HDAC) expression by Western blotting. (A) Western blots of two HATs (GCN5 and PCAF) and eight HDACs (SIRT1, SIRT2, HDACs 1, 2, 3, 4, 5, and 7) with β-actin used as a control. (B) GCN5 (p=0.039) and PCAF (p=0.029) were found to be significantly downregulated, while SIRT1 (p=0.015), SIRT2 (p=0.005), HDAC4 (p=0.002), and HDAC7 (p =0.033) were found to be significantly upregulated, in OL/Hu-H1 cells relative to control cells. There was no significant dysregulation observed in HDAC1 (p=0.196), HDAC2 (p=0.169), HDAC3 (p=0.520), or HDAC5 (p=0.881).