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. 2020 Apr 3;38(16):3201–3209. doi: 10.1016/j.vaccine.2020.03.001

Fig. 1.

Fig. 1

VLP-antigen constructs. Constructs contain linker regions composed of glycine and serine residues to provide flexibility and a Strep-tag for purification. CFHbp sequence refers to residues H157 to Q274 of the FHbp ORF from strain MC58 (PubMLST allele designation: 1); this corresponds to the C-terminal domain comprising approximately half the mature protein [13]. NadA sequence refers to residues A26 to G309 of the NadA ORF from strain MC58 (PubMLST allele designation: 1); this corresponds to the N-terminal globular and subsequent coiled-coil domains, encompassing all of the soluble parts of the mature protein [18].