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. 2008 Aug 4:219–233. doi: 10.1007/978-1-4020-9063-9_12

Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance

Janko Nikolich-Žugich 5, Anna Lang 5
Editors: Tamas Fulop1, Claudio Franceschi2, Katsuiku Hirokawa3, Graham Pawelec4
PMCID: PMC7114977

Abstract

Age-related T-cell clonal expansions (TCE) are an incompletely understood disturbance in T-cell homeostasis found frequently in old humans and experimental animals. These accumulations of CD8 T-cells have the potential to distort T-cell population balance and reduce T-cell repertoire diversity above and beyond the changes seen in the aging of T-cell pool in the absence of TCE. This chapter discusses our current knowledge of the role of these expansions in health and disease, with a special focus on their influence upon immune defense against infectious diseases.

Keywords: Ageing, Clonal expansions, Homeostasis, Infectious diseases, T-cells

Contributor Information

Tamas Fulop, Email: tamas.fulop@usherbrooke.ca.

Claudio Franceschi, Email: claudio.franceschi@unibo.it.

Graham Pawelec, Email: graham.pavelec@uni-tuebingen.de.

Janko Nikolich-Žugich, Phone: +1-520-626-6065, FAX: +1-520-626-2100, Email: nikolich@arizona.edu.

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