Incubation |
|
|
|
Typical |
7–10 days |
7–14 days |
7–10 days |
Range |
2–21 days |
2–21 days |
Unknown |
Transmission |
Body fluid exposure |
Contact, droplet |
Arthropod (mosquito) |
Ease of transmission |
High |
Low to medium |
High (in endemic region) |
Secondary cases |
All direct contacts of 1° case |
Some direct contacts of 1° case |
Regional (mosquito driven) |
2° transmission risks |
Any contact with blood, vomitus, diarrhea, saliva, semen |
HCW, contact with patient with high respiratory viral load |
Sexual contacts, breast feeding, transfusion, droplet (?) |
Primary at-risk groups |
HCW, family, close friends |
HCW, close contacts (of severely ill patients) |
All residing in endemic region, sexual contacts |
Geography of cases |
West Africa; importation of ill HCW to host countries |
Arabian peninsula, North Africa, South Korea |
South and Central America, Caribbean basin, South Florida |
Goal for vaccine |
Prevention of infection |
Prevention of infection |
Prevention of infection |
Outcome of interest |
Prevention of mortality |
Prevention of severe pneumonia |
Prevention of microcephaly |
Diagnosis |
PCR (serum) |
PCR (lower respiratory) |
PCR (serum, saliva, urine), serology |
Commercial Dx assay |
Yes |
Yes |
No, EUA only |
Correlates of protection |
Not defined |
Not defined |
Not defined |
Timing of outbreak |
December 2013 - January 2016 |
Ongoing with periodic outbreaks |
Ongoing transmission & spread |