Table 3.
Antibody responses after subcutaneous immunization of Balb/c mice and survival after intranasal challenge with WNVwt virus.
| Preparation | Antigen (ng) | Survivala, n/n total (%) | μNT-Titer, GMT (SD) |
|---|---|---|---|
| WNVwt | 1000 | 20/20 (100) | 306 (207) |
| 250 | 20/20 (100) | 190 (0) | |
| 63 | 20/20 (100) | 98 (52) | |
| 16 | 14/20 (70) | 15 (2.7) | |
| 4 | 5/20 (25) | 9 (2.7) | |
| WNVsyn | 1000 | 19/20 (95) | 237 (14.5) |
| 250 | 20/20 (100) | 155 (28.3) | |
| 63 | 20/20 (100) | 129 (7.8) | |
| 16 | 19/20 (95) | 45 (21.8) | |
| 4 | 12/20 (60) | 15 (2.7) | |
| Mock | 0 (PBS) | 1/20 (5) | <7.1 |
a
Challenge dose 2 × 105 TCID50 per animal; results of two independent experiments were combined.