Skip to main content
NCBI home page
Elsevier - PMC COVID-19 Collection logoLink to Elsevier - PMC COVID-19 Collection
. 2002 Nov 13;31(1):1–10. doi: 10.1016/0378-1135(92)90135-G

Coronavirus infection in mink (Mustela vision). Serological evidence of infection with a coronavirus related to transmissible gastroenteritis virus and porcine epidemic diarrhea virus

P Have a, V Moving a, V Svansson b, Å Uttenthal c, B Bloch b
PMCID: PMC7117138  PMID: 1319622

Abstract

Antibodies to a transmissible gastroenteritis virus (TGEV)-related coronavirus have been demonstrated in mink sera by indirect immunofluorescence, peroxidase-linked antibody assays and immunoblotting. This is the first serological evidence of a specific coronavirus infection in mink. The putative mink coronavirus (MCV) seems to be widespread in the Danish mink population with a prevalence approaching 100%. Analysis by immunoblotting has shown that MCV is closely related to TGEV by the spike (S), matrix (M) and nucleoprotein (N) polypeptides. Furthermore, antibodies to MCV also cross-reacted with N and M polypeptides of porcine epidemic diarrhea virus (PEDV). Thus MCV may occupy an intermediate position between the TGEV group of coronaviruses and PEDV. The possibility that MCV may be associated with syndromes of acute enteritis in preweaning mink is discussed.

References

  1. Cavanagh D., Brian D.A., Enjuanes L., Holmes K.V., Lai M.M.C., Laude H., Siddell S.G., Spaan W., Taguchi F., Talbot P.J. Recommendations of the coronavirus study group for the nomenclature of the structural proteins, messenger RNAs, and genes of coronacviruses. Virology. 1990;176:306–307. doi: 10.1016/0042-6822(90)90259-T. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Egberink H.F., Ederveen J., Callebaut P., Horzinek M.C. Characterization of the structural proteins of porcine epizootic diarrhea virus, strain CV777. Am. J. Vet. Res. 1988;49:1320–1324. [PubMed] [Google Scholar]
  3. Gorham J.R., Evermann J.F., Ward A., Pearson D., Shen D., Hartsough G.R., Leathers C. Detection of coronavirus-like particles from mink with epizootic catarrhal gastroenteritis. Can. J. Vet. Res. 1990;54:383–384. [PMC free article] [PubMed] [Google Scholar]
  4. Have P. Infection with a new porcine respiratory coronavirus in Denmark. Serologic differentiation from transmissible gastroenteritis virus using monoclonal antibodies. In: Cavanagh D., Brown T.D.K., editors. Coronaviruses and their diseases. Advances in experimental medicine and biology. Plenum Publishing Corporation; 1991. in press. [DOI] [PubMed] [Google Scholar]
  5. Henriksen P. So-called “wet mink kits” — Acute enteritis in pre-weaning mink. Fur Rancher. 1989;69:8–9. [Google Scholar]
  6. Hofmann M., Wyler R. Propagation of the virus of porcine epidemic diarrhea in cell culture. J. Clin. Microbiol. 1988;26:2235–2239. doi: 10.1128/jcm.26.11.2235-2239.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jensen M.H. Detection of antibodies against hog cholera virus and bovine viral diarrhea virus in porcine serum. Acta Vet. Scand. 1981;22:85–98. doi: 10.1186/BF03547210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680–685. doi: 10.1038/227680a0. [DOI] [PubMed] [Google Scholar]
  9. Larsen A.E., Gorham J.R. A new mink enteritis: An initial report. Vet. Med. 1975;70:291–292. [PubMed] [Google Scholar]
  10. McClurkin A.W., Norman J.O. Studies on transmissible gastroenteritis of swine. II. Selected characteristics of a cytopathogenic virus common to five isolates of transmissible gastroenteritis. Can. J. Comp. Med. Vet. Sci. 1966;30:190–198. [PMC free article] [PubMed] [Google Scholar]
  11. Pensaert M.B., Debouck P., Reynolds D.J. An immunoelectron micoscopic and immunoflourescent study on the antigenic relationhip between the coronavirus-like agent, C777, and several coronaviruses. Arch. Virol. 1981;68:45–52. doi: 10.1007/BF01315166. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Pensaert M., Callebaut P., Vergote J. Isolation of a porcine respiratory, non-enteric coronavirus related to transmissible gastroenteritis. Vet. Q. 1986;8:257–261. doi: 10.1080/01652176.1986.9694050. [DOI] [PubMed] [Google Scholar]
  13. Porter D.D., Larsen A.E., Porter H.G. Aleutian disease of mink. Adv. Immunol. 1980;29:261–286. doi: 10.1016/s0065-2776(08)60046-2. [DOI] [PubMed] [Google Scholar]
  14. Reed L.J., Muench H. A simple method of estimating fifty percent endpoints. Am. J. Hyg. 1938;27:493–497. [Google Scholar]
  15. Sanchez C.M., Jimenez G., Laviada M.D., Correa I., Sune C., Bullido M.J., Gebauer F., Smerdou C., Callebaut P., Escribano J.M., Enjuanes L. Antigenic homology among coronaviruses related to transmissible gastroenteritis virus. Virology. 1990;174:410–417. doi: 10.1016/0042-6822(90)90094-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Siddell S., Wege H., Ter Meulen V. The biology of coronaviruses. J. Gen. Virol. 1983;64:761–776. doi: 10.1099/0022-1317-64-4-761. [DOI] [PubMed] [Google Scholar]
  17. Sturman L.s., Holmes K.V. The molecular biology of coronaviruses. Adv. Virus Res. 1983;28:35–112. doi: 10.1016/S0065-3527(08)60721-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Yaling Z., Ederveen J., Egberink H., Pensaert M., Horzinek M.C. Porcine epidemic diarrhea virus (CV 777) and feline infectious peritonitis virus (FIPV) are antigenically related. Arch. Virol. 1988;102:63–71. doi: 10.1007/BF01315563. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Veterinary Microbiology are provided here courtesy of Elsevier

RESOURCES