Fig. 7. Coadministration of ATL and olaparib induces regression of tumor xenografts.

PC-3 cells (2 × 10⁶) in 1:1 matrigel were inoculated subcutaneously into the left flanks of male athymic BALB/c nude mice. When the tumor volume reached approximately 150 mm³ (15 days after inoculation), mice were treated once daily with 50 mg/kg ATL oral gavage or 50 mg/kg olaparib intraperitoneal injection or both for 15 days. a Photograph of tumors dissected out from each mouse at the time of study termination. b Tumor volumes measured on the indicated days of treatment. Results were shown as mean ± SD. c Tumor weight measured at the end of the study. d Representative images of immunohistochemical staining of γH2AX and TUNEL in tumor tissues (scale bar: 20 μm). e Hematoxylin-eosin staining of liver, heart, and kidney tissue sections (magnification: ×400). n.s. not significant, ***p < 0.001 vs. vehicle control.