Skip to main content
Springer Nature - PMC COVID-19 Collection logoLink to Springer Nature - PMC COVID-19 Collection
. 2020 Mar 31;63(5):771–773. doi: 10.1007/s11427-020-1690-y

The brain, another potential target organ, needs early protection from SARS-CoV-2 neuroinvasion

Zhengqian Li 1, Yuguang Huang 2, Xiangyang Guo 1,
PMCID: PMC7118308  PMID: 32246403

The content is available as a PDF (386.1 KB).

Acknowledgements

This work was supported by Peking University “Clinical Medicine plus X” Youth Project (PKU2020LCXQ016) and the National Natural Science Foundation of China (81971012, 81873726).

Compliance and ethics The author(s) declare that they have no conflict of interests.

References

  1. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–513. doi: 10.1016/S0140-6736(20)30211-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Desforges M, Le Coupanec A, Dubeau P, Bourgouin A, Lajoie L, Dubé M, Talbot PJ. Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Viruses. 2020;12:14. doi: 10.3390/v12010014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hamming I, Timens W, Bulthuis MLC, Lely AT, Navis GJ, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004;203:631–637. doi: 10.1002/path.1570. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Mao, L., Wang, M., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., Li, Y., Jin, H., et al. (2020). Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. MedRxiv, doi: 10.1101/2020.02.22.20026500.
  5. Li, Y.C., Bai, W.Z., and Hashikawa, T. (2020). The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients. J Med Virol, in press. [DOI] [PMC free article] [PubMed]
  6. Lee AM, Wong JGWS, McAlonan GM, Cheung V, Cheung C, Sham PC, Chu CM, Wong PC, Tsang KWT, Chua SE. Stress and psychological distress among SARS survivors 1 year after the outbreak. Can J Psychiatry. 2007;52:233–240. doi: 10.1177/070674370705200405. [DOI] [PubMed] [Google Scholar]
  7. China NHCotPsRo. (2020). The guidelines for the diagnosis and treatment of novel coronavirus (2019-nCoV) infection (trial version 7) (in Chinese). http://www.nhc.gov.cn/yzygj/s7653p/202003/46c9294a7dfe4cef80dc7f5912eb1989/files/ce3e6945832a438eaae415350a8ce964.pdf.
  8. Toth P, Tarantini S, Csiszar A, Ungvari Z. Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging. Am J Physiol-Heart Circulatory Physiol. 2017;312:H1–H20. doi: 10.1152/ajpheart.00581.2016. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Science China. Life Sciences are provided here courtesy of Nature Publishing Group

RESOURCES