Abstract
This report of a randomized, double-masked, placebo-controlled clinical study demonstrates the effectiveness of zinc acetate lozenges on common cold symptoms in allergy-tested subjects. Subjects in the zinc and placebo groups were evenly matched with respect to sex, race/ethnicity, allergy test status, and age. Overall symptom duration was significantly less in the zinc group than in the placebo group (mean, 3.8 day vs 5.1 days). The mean severity rating for all symptoms was lower in the zinc group than in the placebo group; this difference, however, was not statistically significant. Allergy-positive subjects who used zinc had a statistically significant shorter duration of nasal symptoms than allergy-negative subjects (3.5 days vs 7.6 days). In conclusion, we propose that zinc acetate lozenges may significantly shorten the duration of common cold symptoms and relieve symptoms associated with allergies
Keywords: zinc acetate, common cold, allergies, lozenges
References
- 1.Somerviller ED. Time-Life Books; Richmond, Va: 1996. pp. 280–283. (The Medical Advisor). [Google Scholar]
- 2.Murphy W. Time-Life Books; Alexandria, Va: 1981. (Coping with the Common Cold). [Google Scholar]
- 3.Mainous A, III, Hueston WJ, Calk JR. Antibiotics and upper respiratory infection: Do some folks think there is a cure for the common cold? J Fam Pract. 1996;42:357–361. [PubMed] [Google Scholar]
- 4.Castleman M. Fawcett Columbine; New York: 1987. (Cold Cures). [Google Scholar]
- 5.Engel JP. Viral respiratory infections. Semin Respir Infect. 1995;10:3–13. [PubMed] [Google Scholar]
- 6.Douglas RG., Jr Pathogenesis of rhinovirus common colds in human volunteers. Ann Otol Rhinol Laryngol. 1970;79:563–571. doi: 10.1177/000348947007900320. [DOI] [PubMed] [Google Scholar]
- 7.Luks D, Anderson MR. Antihistamines and the common cold. A review and critique of the literature. J Gen Intern Med. 1996;11:240–244. doi: 10.1007/BF02642483. [DOI] [PubMed] [Google Scholar]
- 8.Hemila H. Vitamin C intake and susceptibility to the common cold. Br J Nutr. 1997;77:59–72. doi: 10.1017/s0007114500002889. [DOI] [PubMed] [Google Scholar]
- 9.Korant BD, Kauer JC, Butterworth BE. Zinc ions inhibit replication of rhinoviruses. Nature. 1974;248:588–590. doi: 10.1038/248588a0. [DOI] [PubMed] [Google Scholar]
- 10.Eby GA. George Eby Research; Austin TX: 1994. (Handbook for Curing the Common Cold. The Zinc Lozenge Story). Available at: http://coldcure.com/html/cover.html. [Google Scholar]
- 11.Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother. 1984;25:20–24. doi: 10.1128/aac.25.1.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 12.Al-Nakib W, Higgins PG, Barrow I. Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges. J Antimicrob Chemother. 1987;20:893–901. doi: 10.1093/jac/20.6.893. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 13.Mossad SB, Macknin ML, Medendorp SV, Mason P. Zinc gluconate lozenges for treating the common cold: A randomized, double-blind, placebo-controlled study. Ann Intern Med. 1996;125:81–88. doi: 10.7326/0003-4819-125-2-199607150-00001. [DOI] [PubMed] [Google Scholar]
- 14.Farr BM, Conner EM, Betts RF. Two randomized controlled trials of zinc gluconate lozenge therapy of experimentally induced rhinovirus colds. Antimicrob Agents Chemother. 1987;31:1183–1187. doi: 10.1128/aac.31.8.1183. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Douglas RM, Miles HB, Moore BW. Failure of effervescent zinc acetate lozenges to alter the course of upper respitaroy infections in Australian adults. Antimicrob Agents Chemother. 1987;31:1263–1265. doi: 10.1128/aac.31.8.1263. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Smith DS, Helzner EC, Nuttall CE. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrob Agents Chemother. 1989;33:646–648. doi: 10.1128/aac.33.5.646. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17.Weismann K, Jakobsen JP, Weissmann JE. Zinc gluconate lozenges for common cold: A double-blind clinical trial. Dan Med Bull. 1990;37:279–291. [PubMed] [Google Scholar]
- 18.Macknin ML, Piedmonte J, Calendine C. Zinc gluconate lozenges for treating common cold in children. JAMA. 1998;279:1962–1967. doi: 10.1001/jama.279.24.1962. [DOI] [PubMed] [Google Scholar]
- 19.Jackson JL, Peterson C, Lesho E. A meta-analysis of zinc salts lozenges and the common cold. Arch Intern Med. 1997;157:2373–2376. [PubMed] [Google Scholar]
- 20.Godfrey JC, Conant SB, Smith DS. Zinc gluconate and the common cold: A controlled clinical study. J Int Med Res. 1992;20:234–246. doi: 10.1177/030006059202000305. [DOI] [PubMed] [Google Scholar]
- 21.Browner WS, Black D, Thomas B. Estimating sample size and power. In: Hully SB, Cummings SR, editors. Vol. 215. Williams & Wilkins; Baltimore: 1988. pp. 139–150. (Designing Clinical Research). [Google Scholar]
- 22.Hays WL. 4th ed. Rinehart and Winston, Inc; New York, Holt: 1988. p. 303. (Statistics). [Google Scholar]
- 23.SPSS Inc; Chicago Ill: 1997. (SPSS Base 7.5 Applications Guide). [Google Scholar]
- 24.Eby GA. Zinc ion availability—the determination of efficacy in zinc lozenge treatment of common colds. J Antimicrob Chemother. 1997;40:483–493. doi: 10.1093/oxfordjournals.jac.a020864. [DOI] [PubMed] [Google Scholar]
- 25.Hatch B, Berthon G. Metal ion-FTS nonapeptide interactions. A quantitative study of zinc(II)-nonapeptide complexes (thymulin) under physiological conditions and assessment of their biological significance. Inorganica Chimica Acta. 1987;136:165–171. [Google Scholar]
- 26.Prasad AS. Zinc deficiency in women, infants and children. J Am Coll Nutr. 1996;15:113–120. doi: 10.1080/07315724.1996.10718575. [DOI] [PubMed] [Google Scholar]
- 27.Turner RB. Epidemiology, pathogenesis, and treatment of the common cold. Ann Allergy Asthma Immunol. 1997;78:531–539. doi: 10.1016/S1081-1206(10)63213-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 28.Novick SG, Godfrey JC, Godfrey NJ, Wilder HR. How does zinc modify the common cold? Clinical observations and implications regarding mechanisms of action. Med Hypotheses. 1996;46:295–302. doi: 10.1016/s0306-9877(96)90259-5. [DOI] [PubMed] [Google Scholar]
- 29.Eby GA, Halcomb WW. Use of topical zinc to prevent recurrent herpes simplex infection: Review of literature and suggested protocols. Med Hypotheses. 1985;17:157–165. doi: 10.1016/0306-9877(85)90142-2. [DOI] [PubMed] [Google Scholar]
- 30.Korant BD. Role of cellular and viral proteases in the processing of picornavirus proteins. In: Perez-Bercoff R, editor. Plenum Publishing; New York: 1979. pp. 149–173. (The Molecular Biology of Picornaviruses). [Google Scholar]
- 31.Gallagher IHC, Cutress TW. The effect of tract elements on the growth and fermentation of oral streptococci and actinomyces. Arch Oral Biol. 1977;22:555–562. doi: 10.1016/0003-9969(77)90066-8. [DOI] [PubMed] [Google Scholar]
- 32.Budavari S, O'Neil MJ, Smith A. 12th ed. Merck Research Labs; Whitehouse Station, NJ: 1996. p. 10262. (The Merck Index). [Google Scholar]
- 33.Osol A. Astringents and antiperspirants. In: Osol A, editor. 16th ed. Mack Publishing Co; Easton: 1980. pp. 720–723. (Remington's Pharmaceutical Sciences). [Google Scholar]
- 34.Sugarman B. Zinc and infection. Rev Infect Dis. 1983;5:137–147. doi: 10.1093/clinids/5.1.137. [DOI] [PubMed] [Google Scholar]
- 35.Kazimiercak W, Maslinski C. Histamine release from mast cells by compound 48/80. The membrane action of zinc. Agents Actions. 1974;4:320–323. doi: 10.1007/BF01964934. [DOI] [PubMed] [Google Scholar]
- 36.Pasternak CA. A novel form of host defense: Membrane protection by calcium and zinc ions. Biosc Rep. 1987;7:81–91. doi: 10.1007/BF01121871. [DOI] [PubMed] [Google Scholar]
- 37.Struckhoff G, Heymann E. Rat peritoneal mast cells release dipeptidyl peptidase II. Biochem J. 1986;236:215–219. doi: 10.1042/bj2360215. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 38.Marone G, Findlay AR, Lictenstein LM. Modulation of histamine release from human basophils in vitro by physiological concentrations of zinc. J Pharmacol Exp Ther. 1981;217:292–298. [PubMed] [Google Scholar]
- 39.Pasternak CA. Virus, toxin, complement: Common actions and their prevention by Ca2+ or Zn2+ Bioessays. 1987;6:14–19. doi: 10.1002/bies.950060105. [DOI] [PubMed] [Google Scholar]