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. 2003 Mar 27;28(1):121–126. doi: 10.1016/0022-510X(76)90053-8

Intracisternal virus-like particles in brain of a multiple sclerosis patient☆

Ryuichi Tanaka 1,2,1, Yuzo Iwasaki 1,2, Hilary Koprowski 1,2
PMCID: PMC7118424  PMID: 932771

Abstract

Doughnut-shaped particles, 55–65 nm in diameter, were revealed by electron microscopy in the cisterns of the rough endoplasmic reticulum of cells from an active lesion in autopsied brain tissue from a multiple sclerosis patient. The morphology of the particles closely resembled that of coronaviruses.

Footnotes

☆

This investigation was supported in part by funds from the John A. Hartford Foundation, Inc., the National Multiple Sclerosis Society and USPHS Research Grant NS-11036 from the National Institute of Neurological Diseases and Stroke.

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