Table 1.
The preliminary study on MS and MS/MS data of the identified components in rat plasma after oral administration of Flos Lonicerae extracts in negative mode.
| Peak no. | Components | Chemical profiles in vitro | Chemical profiles in rat plasma |
ESI−, [M−H]− | Source | |
|---|---|---|---|---|---|---|
| Flos Lonicerae extracts | Flos Lonicerae extracts | Flos Lonicerae extracts + COS | MS | |||
| 1 | Caffeic acid | + | + | + | 179.03389 | Phenolic acids |
| 2 | Quinic acid | + | + | + | 191.05501 | Phenolic acids |
| 3 | Neochlorogenic acid | + | + | + | 353.08671 | Phenolic acids |
| 4 | Chlorogenic acid | + | + | + | 353.08671 | Phenolic acids |
| 5 | Cryptochlorogenic a cid | + | + | + | 353.08671 | Phenolic acids |
| 6 | 3,5-Dicaffeoylquinic acid | + | + | + | 515.11840 | Phenolic acids |
| 7 | 3,4-Dicaffeoylquinic acid | + | + | + | 515.11840 | Phenolic acids |
| 8 | Luteolin | + | + | + | 285.03936 | Flavones |
| 9 | Galuteolin | + | − | − | 447.09219 | Flavones |
| 10 | Luteolin-7-o-β-d-glucopyranoside | + | − | − | 447.09219 | Flavones |
| 11 | Luteolin-7-o--β-d-galactoside | + | − | − | 447.09219 | Flavones |
| 12 | Hyperoside | + | − | − | 463.08710 | Flavones |
| 13 | Apigenin | + | + | + | 269.04445 | Flavones |
| 14 | Quercetin | + | + | + | 301.03428 | Flavones |
| 15 | Naringenin | + | + | + | 271.06010 | Flavones |
| 16 | Rutin | + | − | − | 609.14501 | Flavones |
| 17 | Diosmetin-7-o-β-d-glucopyranoside | + | − | − | 461.10784 | Flavones |
| 18 | Genistein | + | + | + | 269.04445 | Flavones |
| 19 | Genistein-5-o-β-d-glucopyranoside | + | − | − | 431.09727 | Flavones |
| 20 | Chrysoeriol-7-o-β-d-glucopyranoside | + | − | − | 461.10784 | Flavones |
| 21 | Isorhamnetin-3-o-β-d-glucopyranoside | + | − | − | 477.10275 | Flavones |
| 22 | Kaempferol-3-o-β-d-glucopyranoside | + | − | − | 447.09219 | Flavones |
| 23 | 5,7,4′-Trihydroxyflavanone-7-o--β-d-glucopyranoside | + | − | − | 433.11292 | Flavones |
| 24 | Cosmosiin | + | − | − | 431.09727 | Flavones |
| 25 | Apigenin-7-o-neohesperidoside | + | − | − | 577.15518 | Flavones |
| 26 | Apigenin-7-o-gentibioside | + | − | − | 593.15010 | Flavones |
| 27 | Apigenin-7-o-sophoroside | + | − | − | 593.15010 | Flavones |
| 28 | Secosyloganin | + | − | − | 403.12349 | Iridoids |
| 29 | Luteolin of methylation | − | + | + | 461.10784 | Metabolites |
| 30 | Luteolin-o-glucuronide | − | + | + | 461.07145 | Metabolites |
| 31 | Apigenin of methylation | − | + | + | 283.06010 | Metabolites |
| 32 | Apigenin-o-glucuronide | − | + | + | 446.08436 | Metabolites |
| 33 | Quercetin of methylation | − | + | + | 315.04993 | Metabolites |
| 34 | Quercetin-o-glucuronide | − | + | + | 477.06637 | Metabolites |
| 35 | Genistein of methylation | − | + | + | 283.06010 | Metabolites |
| 36 | Genistein-o-glucuronide | − | + | + | 445.07654 | Metabolites |
| 37 | Naringenin of methylation | − | + | + | 285.07575 | Metabolites |
| 38 | Naringenin-o-glucuronide | − | + | + | 447.09219 | Metabolites |
| 39 | Cosmosiin of methylation | − | + | + | 371.11253 | Metabolites |
| 40 | Cosmosiin of glucuronide | − | + | + | 533.12897 | Metabolites |