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. 2002 Nov 13;11(1):41–51. doi: 10.1016/0165-5728(86)90073-1

Studies on the intrathecal humoral immune response in canine distemper encephalitis☆

M Vandevelde 1,∗, A Zurbriggen 1, A Steck 2, P Bichsel 1
PMCID: PMC7119885  PMID: 3944250

Abstract

Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinating lesions and elevated in dogs with inflammatory myelin lesions. Specific antibodies against CDV and myelin were quantitated in CSF and serum from 8 dogs with an elevated IgG index. Eight of these dogs had significant amounts of antimyelin antibody and 4 dogs had neutralizing anti-CDV antibody in the CSF. Whereas the pathogenetic significance of antimyelin antibodies remains uncertain, the intrathecal antiviral immune response provides a plausible explanation for immunopathologic destruction of myelin in distemper.

Keywords: Anti-CDV antibodies, Antimyelin antibodies, Canine distemper, IgG index

Footnotes

☆

This work was supported by the Swiss National Foundation Grants Nos. 3.949.84 and 3.52.082.

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