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. 2002 Nov 13;18(3):245–253. doi: 10.1016/0165-5728(88)90102-6

Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes

E Lavi a,∗, A Suzumura b,∗∗, DM Murasko a,∗∗∗, EM Murray a, DH Silberger b, SR Weiss a,a
PMCID: PMC7120086  PMID: 2452831

Abstract

The effect of tumor necrosis factor (TNF) on expression of major histocompatibility complex (MHC) antigens was examined in mouse glial cells in vitro. TNF induced MHC class I, but not class II, antigen expression on the surface of astrocytes but not on oligodendrocytes. Glial cells do not normally express detectable amounts of MHC antigens. Thus TNF may play a role in the immunopathogenesis of neurologic diseases that involve MHC class I-restricted reactions.

Keywords: Tumor necrosis factor, Major histocompatibility complex antigen, Glial cell, Astrocyte, Oligodendrocyte

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