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. 2005:1043–1109. doi: 10.1007/978-3-540-26577-1_27

Reproductive Epidemiology

Jørn Olsen 3, Olga Basso 4
Editors: Wolfgang Ahrens1,2, Iris Pigeot1,2
PMCID: PMC7120091

Abstract

In writing this chapter we assumed that the reader is familiar with the basic concepts in epidemiology. You will not find any overview of different designs, measure of disease occurrence, standardisations, other ways of adjusting for confounders, or any general discussion on bias, confounding or on measuring effects. If you are not familiar with these topics you should start by reading other parts of the book or turn to one of the many fine available textbooks.

Keywords: Birth Weight, Preterm Birth, Spontaneous Abortion, Placenta Previa, Last Menstrual Period

References

  1. AbouZahr C. Maternal mortality overview. In: Murray C.J.L., Lopez A.D., editors. Health dimensions of sex and reproduction. Boston, USA: Harvard University Press; 1998. p. 144. [Google Scholar]
  2. Adams M., Andersen A.M., Andersen P.K., Haig D., Henriksen T.B., Hertz-Picciotto I., Lie R.T., Olsen J., Skjaerven R., Wilcox A. Sostrup statement on low birth weight (LBW) Int J Epidemiol. 2003;32(5):884–885. doi: 10.1093/ije/dyg271. [DOI] [PubMed] [Google Scholar]
  3. Adams M.M., Berg C.J., Rhodes P.H., McCarthy B.J. Another look at the black white gap in gestation-specific perinatal mortality. Int J Epidemiol. 1991;20(4):950–957. doi: 10.1093/ije/20.4.950. [DOI] [PubMed] [Google Scholar]
  4. Alderete E., Eskenazi B., Sholtz R. Effect of cigarette smoking and coffee drinking on time to conception. Epidemiology. 1995;6(4):403–408. doi: 10.1097/00001648-199507000-00013. [DOI] [PubMed] [Google Scholar]
  5. Alfirevic Z., Roberts D., Martlew V. How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review. Eur J Obstet Gynecol Reprod Biol. 2002;101(1):6–14. doi: 10.1016/S0301-2115(01)00496-1. [DOI] [PubMed] [Google Scholar]
  6. Ananth C.V., Demissie K., Smulian J.C., Vintzileos A.M. Relationship among placenta previa, fetal growth restriction, and preterm delivery: a populationbased study. Obstet Gynecol. 2001;98(2):299–306. doi: 10.1016/S0029-7844(01)01413-2. [DOI] [PubMed] [Google Scholar]
  7. Andersen A.M., Vastrup P., Wohlfahrt J., Andersen P.K., Olsen J., Melbye M. Feverin pregnancy and risk of fetal death: a cohort study. Lancet. 2002;360(9345):1552–1556. doi: 10.1016/S0140-6736(02)11518-2. [DOI] [PubMed] [Google Scholar]
  8. Askling J., Erlandsson G., Kaijser M., Akre O., Ekbom A. Sickness in pregnancy and sex of child. Lancet. 1999;354(9195):2053. doi: 10.1016/S0140-6736(99)04239-7. [DOI] [PubMed] [Google Scholar]
  9. Baird D.D., Ragan B.N., Wilcox A.J., Weinberg C.R. The relationship between reduced fecundability and subsequent foetal loss. In: Gray R., Leridon H., Spira A., editors. Biomedical and demographic determinants of reproduction. Oxford: Clarendon Press; 1993. pp. 329–341. [Google Scholar]
  10. Baird D.D., Weinberg C.R., Schwingl P., Wilcox A.J. Selection bias associated with contraceptive practice in time-to-pregnancy studies. Ann N Y Acad Sci. 1994;709:156–164. doi: 10.1111/j.1749-6632.1994.tb30395.x. [DOI] [PubMed] [Google Scholar]
  11. Baird D.D., Wilcox A.J. Cigarette smoking associated with delayed conception. JAMA. 1985;253(20):2979–2983. doi: 10.1001/jama.253.20.2979. [DOI] [PubMed] [Google Scholar]
  12. Baird D.D., Wilcox A.J., Weinberg C.R. Use of time to pregnancy to study environmental exposures. Am J Epidemiol. 1986;124(3):470–480. doi: 10.1093/oxfordjournals.aje.a114417. [DOI] [PubMed] [Google Scholar]
  13. Barker D.J. Mothers, babies and disease in later life. London: BMJ publishing Group; 1994. [Google Scholar]
  14. Barker D.J. Fetal origins of coronary heart disease. BMJ. 1995;311(6998):171–174. doi: 10.1136/bmj.311.6998.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Barker D.J. Mothers, babies and health later in life. 2nd edn. Edinburgh: Churchill Livingstone; 1998. [Google Scholar]
  16. Basso O., Christensen K., Olsen J. Higher risk of pre-eclampsia after change of partner. An effect of longer interpregnancy intervals? Epidemiology. 2001;12(6):624–629. doi: 10.1097/00001648-200111000-00008. [DOI] [PubMed] [Google Scholar]
  17. Basso O., Fonager K., Olsen J. Are pregnancies shorter in leap years? Epidemiology. 2000;11(6):736–737. doi: 10.1097/00001648-200011000-00023. [DOI] [PubMed] [Google Scholar]
  18. Basso O., Juul S., Olsen J. Time to pregnancy as a correlate of fecundity: differential persistence in trying to become pregnant as a source of bias. Int J Epidemiol. 2000;29(5):856–861. doi: 10.1093/ije/29.5.856. [DOI] [PubMed] [Google Scholar]
  19. Basso O., Olsen J., Christensen K. Risk of preterm delivery, low birthweight and growth retardation following spontaneous abortion: a registry-based study in Denmark. Int J Epidemiol. 1998;27(4):642–646. doi: 10.1093/ije/27.4.642. [DOI] [PubMed] [Google Scholar]
  20. Basso O., Olsen J., Christensen K. Low birthweight and prematurity in relation to paternal factors: a study of recurrence. Int J Epidemiol. 1999;28(4):695–700. doi: 10.1093/ije/28.4.695. [DOI] [PubMed] [Google Scholar]
  21. Basso O., Olsen J., Knudsen L.B., Christensen K. Low birth weight and preterm birth after short interpregnancy intervals. Am J Obstet Gynecol. 1998;178(2):259–263. doi: 10.1016/S0002-9378(98)80010-0. [DOI] [PubMed] [Google Scholar]
  22. Basso O., Weinberg C.R., Baird D.D., Wilcox A.J., Olsen J. Subfecundity as a correlate of preeclampsia: a study within the Danish National Birth Cohort. Am J Epidemiol. 2003;157(3):195–202. doi: 10.1093/aje/kwf194. [DOI] [PubMed] [Google Scholar]
  23. Berkowitz G.S., Papiernik E. Epidemiology of preterm birth. Epidemiol Rev. 1993;15(2):414–443. doi: 10.1093/oxfordjournals.epirev.a036128. [DOI] [PubMed] [Google Scholar]
  24. Bianchi D.W. Fetomaternal cell trafficking: a new cause of disease? Am J Med Genet. 2000;91(1):22–28. doi: 10.1002/(SICI)1096-8628(20000306)91:1<22::AID-AJMG4>3.0.CO;2-3. [DOI] [PubMed] [Google Scholar]
  25. Bianchi D.W., Zickwolf G.K., Weil G.J., Sylvester S., DeMaria M.A. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc Natl Acad Sci USA. 1996;93(2):705–708. doi: 10.1073/pnas.93.2.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Blair E., Stanley F. When can cerebral palsy be prevented? The generation of causal hypotheses by multivariate analysis of a case-control study. Paediatr Perinat Epidemiol. 1993;7(3):272–301. doi: 10.1111/j.1365-3016.1993.tb00405.x. [DOI] [PubMed] [Google Scholar]
  27. Bolumar F., Olsen J., Boldsen J. Smoking reduces fecundity: a European multicenter study on infertility and subfecundity. Am J Epidemiol. 1996;143(6):578–587. doi: 10.1093/oxfordjournals.aje.a008788. [DOI] [PubMed] [Google Scholar]
  28. Bonde J.P., Ernst E., Jensen T.K., Hjollund N.H.I., Kolstad H., Henriksen T.B., Scheike T., Givercman A., Olsen J., Skakkebaek N.E. Relation between semen quality and fertility, a population-based study of 430 first-pregnancy planners. Lancet. 1998;352(9135):1172–1177. doi: 10.1016/S0140-6736(97)10514-1. [DOI] [PubMed] [Google Scholar]
  29. Bonde J.P., Hjollund N.H.I., Jensen T.K., Ernst E., Kolstad H., Henriksen T.B., Givercman A., Skakkebaek N.E., Andersen A.M., Olsen J. A follow-up study of environmental and biologic determinants of fertility among 430 Danish first-pregnancy planners: design and methods. Reprod Toxicol. 1998;12(1):19–27. doi: 10.1016/S0890-6238(97)00096-8. [DOI] [PubMed] [Google Scholar]
  30. Bonomo M., Gandini M.L., Mastropasqua A., Begher C., Valentini U., Faden D., Morabito A. Which cutoff level should be used in screening for glucose intolerance in pregnancy? Am J Obstet Gynecol. 1998;179(1):179–185. doi: 10.1016/S0002-9378(98)70270-4. [DOI] [PubMed] [Google Scholar]
  31. Pipkin F. What is the place of genetics in the pathogenesis of pre-eclampsia? Biol Neonate. 1999;76(6):325–330. doi: 10.1159/000014175. [DOI] [PubMed] [Google Scholar]
  32. Carlsen E., Giwercman A., Keiding N., Skakkebaek N.E. Evidence for decreasing quality of semen during past 50 years. BMJ. 1992;305(6854):609–613. doi: 10.1136/bmj.305.6854.609. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Cnattingius S., Signorello L.B., Anneren G., Clausson B., Ekbom A., Ljunger E., Blot W.J., McLaughlin J.K., Petersson G., Rane A., Granath F. Caffeine intake and the risk of first-trimester spontaneous abortion. N Engl J Med. 2000;343(25):1839–1845. doi: 10.1056/NEJM200012213432503. [DOI] [PubMed] [Google Scholar]
  34. Condé-Agudelo A., Althabe F., Belizan J.M., Kafury-Goeta A.C. Cigarette smoking during pregnancy and risk of preeclampsia: a systematic review. Am J Obstet Gynecol. 1999;181(4):1026–1035. doi: 10.1016/S0002-9378(99)70341-8. [DOI] [PubMed] [Google Scholar]
  35. Coughlin M.T., LaPorte R.E., O’Leary L.A., Lee P.A. How accurate is male recall of reproductive information? Am J Epidemiol. 1998;148(8):806–809. doi: 10.1093/oxfordjournals.aje.a009702. [DOI] [PubMed] [Google Scholar]
  36. Cramer DW, Goldman MB (guest eds) (1994) Infertility and reproductive medicine. Study designs and statistics for infertility research. Clinics of North America vol 5(2). W. B. Saunders Company, Philadelphia, USA
  37. Dashe J.S., McIntire D.D., Ramus R.M., Santos-Ramos R., Twickler D.M. Persistence of placenta previa according to gestational age at ultrasound detection. Obstet Gynecol. 2002;99(5 Pt 1):692–697. doi: 10.1016/S0029-7844(02)01935-X. [DOI] [PubMed] [Google Scholar]
  38. Dekker G., Sibai B. Primary, secondary, and tertiary prevention of preeclampsia. Lancet. 2001;357(9251):209–215. doi: 10.1016/S0140-6736(00)03599-6. [DOI] [PubMed] [Google Scholar]
  39. Dekker G.A. Risk factors for pre-eclampsia. Clin Obstet Gynecol. 1999;42(3):422–435. doi: 10.1097/00003081-199909000-00002. [DOI] [PubMed] [Google Scholar]
  40. Dekker G.A., Robillard P.Y., Hulsey T.C. Immune maladaptation in the etiology of preeclampsia: a review of corroborative epidemiologic studies. Obstet Gynecol Surv. 1998;53(6):377–382. doi: 10.1097/00006254-199806000-00023. [DOI] [PubMed] [Google Scholar]
  41. Diggle G.E. Thalidomide: 40 years on. Int J Clin Pract. 2001;55(9):627–631. [PubMed] [Google Scholar]
  42. Depue R.H., Bernstein L., Ross R.K., Judd H.L., Henderson B.E. Hyperemesis gravidarum in relation to estradiol levels, pregnancy outcome, and other maternal factors: a seroepidemiologic study. Am J Obstet Gynecol. 1987;156(5):1137–1141. doi: 10.1016/0002-9378(87)90126-8. [DOI] [PubMed] [Google Scholar]
  43. Dornhorst A., Beard R.W. Gestational diabetes: a challenge for the future. Diabet Med. 1993;10(10):897–905. doi: 10.1111/j.1464-5491.1993.tb00004.x. [DOI] [PubMed] [Google Scholar]
  44. Eliakim R., Abulafia O., Sherer D.M. Hyperemesis gravidarum: a current review. Am J Perinatol. 2000;17(4):207–218. doi: 10.1055/s-2000-9424. [DOI] [PubMed] [Google Scholar]
  45. Ericson A., Kallen B., Wiholm B. Delivery outcome after the use of antidepressants in early pregnancy. Eur J Clin Pharmacol. 1999;55(7):503–508. doi: 10.1007/s002280050664. [DOI] [PubMed] [Google Scholar]
  46. Esplin M.S., Fausett M.B., Fraser A. Paternal and maternal components of the predisposition to preeclampsia. N Engl J Med. 2001;344(12):867–872. doi: 10.1056/NEJM200103223441201. [DOI] [PubMed] [Google Scholar]
  47. Flint C., Larsen H., Nielsen G.L., Olsen J., Sorensen H.T. Pregnancy outcome after suicide attempt by drug use: a Danish population-based study. Acta Obstet Gynecol Scand. 2002;81(6):516–522. doi: 10.1034/j.1600-0412.2002.810607.x. [DOI] [PubMed] [Google Scholar]
  48. Gabbe S.G. The gestational diabetes mellitus conferences. Three are history: focus on the fourth. Diabetes Care. 1998;21(Suppl 2):B1–2. [PubMed] [Google Scholar]
  49. Geddes J.R., Lawrie S.M. Obstetric complications and schizophrenia: a metaanalysis. Br J Psychiatry. 1995;167(6):786–793. doi: 10.1192/bjp.167.6.786. [DOI] [PubMed] [Google Scholar]
  50. Gjessing H.K., Skjaerven R., Wilcox A.J. Errors in gestational age: evidence of bleeding early in pregnancy. Am J Public Health. 1999;89(2):213–218. doi: 10.2105/ajph.89.2.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Gladen B.C. On the role of “habitual aborters” in the analysis of spontaneous abortion. Stat Med. 1986;5(6):557–564. doi: 10.1002/sim.4780050602. [DOI] [PubMed] [Google Scholar]
  52. Godsey R.K., Newman R.B. Hyperemesis gravidarum. A comparison of single and multiple admissions. J Reprod Med. 1991;36(4):287–290. [PubMed] [Google Scholar]
  53. Gourbin G., Masuy-Stroobant G. Registration of vital data: are live births and stillbirths comparable all over Europe? Bull World Health Organ. 1995;73(4):449–460. [PMC free article] [PubMed] [Google Scholar]
  54. Graafmans W.C., Richardus J.H., Borsboom G.J., Bakketeig L., Langhoff-Roos J., Bergsjo P., Macfarlane A., Verloove-Vanhorick S.P., Mackenbach J.P., Euro Natal working group Birth weight and perinatal mortality, a comparison of “optimal” birth weight in seven Western European countries. Epidemiology. 2002;13(5):569–574. doi: 10.1097/00001648-200209000-00013. [DOI] [PubMed] [Google Scholar]
  55. Grandjean P., Weihe P., White R.F., Debes F., Araki S., Yokoyama K., Murata K., Sorensen N., Dahl R., Jorgensen P.J. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol. 1997;19(6):417–428. doi: 10.1016/S0892-0362(97)00097-4. [DOI] [PubMed] [Google Scholar]
  56. Gray P.H., O’Callaghan M.J., Mohay H.A., Burns Y.R., King J.F. Maternal hypertension and neurodevelopmental outcome in very preterm infants. Arch Dis Child Fetal Neonatal Ed. 1998;79(2):F88–93. doi: 10.1136/fn.79.2.f88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Gross S., Librach C., Cecutti A. Maternal weight loss associated with hyperemesis gravidarum: a predictor of fetal outcome. Am J Obstet Gynecol. 1989;160(4):906–909. doi: 10.1016/0002-9378(89)90307-4. [DOI] [PubMed] [Google Scholar]
  58. Haig D. Genetic conflicts in human pregnancy. Q Rev Biol. 1993;68(4):495–532. doi: 10.1086/418300. [DOI] [PubMed] [Google Scholar]
  59. Hallak M., Tsalamandris K., Dombrowski M.P., Isada N.B., Pryde P.G., Evans M.I. Hyperemesis gravidarum. Effects on fetal outcome. J Reprod Med. 1996;41(11):871–874. [PubMed] [Google Scholar]
  60. Henriksen T.B., Wilcox A.J., Hedegaard M., Secher N.J. Bias in studies of preterm and post term delivery due to ultrasound assessment of gestational age. Epidemiology. 1995;6(5):533–537. doi: 10.1097/00001648-199509000-00012. [DOI] [PubMed] [Google Scholar]
  61. Hjollund N.H., Jensen T.K., Bonde J.P., Henriksen T.B., Andersson A.M., Kolstad H.A., Ernst E., Giwercman A., Skakkebaek N.E., Olsen J. Spontaneous abortion and physical strain around implantation, a follow-up study of first-pregnancy planners. Epidemiology. 2000;11(1):18–23. doi: 10.1097/00001648-200001000-00006. [DOI] [PubMed] [Google Scholar]
  62. Hoffman E.B., Sen P.K., Weinberg C.R. Within-cluster resampling. Biometrika. 2001;88(4):1121–1134. doi: 10.1093/biomet/88.4.1121. [DOI] [Google Scholar]
  63. Irgens H.U., Reisaeter L., Irgens L.M., Lie R.T. Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study. BMJ. 2001;323(7323):1213–1217. doi: 10.1136/bmj.323.7323.1213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Jacobsen R., Bostofte E., Engholm G., Hansen J., Olsen J.H., Skakkebaek N.E., Moller H. Risk of testicular cancer in men with abnormal semen characteristics: cohort study. BMJ. 2000;321(7264):789–792. doi: 10.1136/bmj.321.7264.789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Jensen T.K., Henriksen T.B., Hjollund N.H.I., Scheike T., Kolstad H., Giwercman A., Ernst E., Bonde J.P., Skakkebaek N.E., Olsen J. Caffeine intake and fecundability. A follow-up study among 430 Danish couples planning their first pregnancy. Reprod Toxicol. 1998;12(3):289–295. doi: 10.1016/S0890-6238(98)00002-1. [DOI] [PubMed] [Google Scholar]
  66. Joffe M., Villard L., Li Z., Plowman R., Vessey M. Long-term recall of time-to-pregnancy. Fertil Steril. 1993;60(1):99–104. doi: 10.1016/s0015-0282(16)56044-0. [DOI] [PubMed] [Google Scholar]
  67. Joffe M., Villard L., Li Z., Plowman R., Vessey M. A time to pregnancy question-naire designed for long term recall: validity in Oxford, England. J Epidemiol Community Health. 1995;49(3):314–319. doi: 10.1136/jech.49.3.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Johnstone F.D., Nasrat A.A., Prescott R.J. The effect of established and gestational diabetes on pregnancy outcome. Br J Obstet Gynaecol. 1990;97(11):1009–1015. doi: 10.1111/j.1471-0528.1990.tb02473.x. [DOI] [PubMed] [Google Scholar]
  69. Juul S., Karmaus W., Olsen J. Regional differences in waiting time to pregnancy: pregnancy-based surveys form Denmark, France, Germany, Italy and Sweden. Hum Reprod. 1999;14(5):1250–1254. doi: 10.1093/humrep/14.5.1250. [DOI] [PubMed] [Google Scholar]
  70. Kallen B. Hyperemesis during pregnancy and delivery outcome: a registry study. Eur J Obstet Gynecol Reprod Biol. 1987;26(4):291–302. doi: 10.1016/0028-2243(87)90127-4. [DOI] [PubMed] [Google Scholar]
  71. Kero J., Gissler M., Gronlund M.M., Kero P., Koskinen P., Hemminki E., Isolauri E. Mode of delivery and asthma — is there a connection? Pediatr Res. 2002;52(1):6–11. doi: 10.1203/00006450-200207000-00004. [DOI] [PubMed] [Google Scholar]
  72. Kiely J.L., Paneth N., Susser M. Fetal death during labor: an epidemiologic indicator of level of obstetric care. Am J Obst Gynecol. 1985;153(7):721–727. doi: 10.1016/0002-9378(85)90331-x. [DOI] [PubMed] [Google Scholar]
  73. Kline J., Stein Z., Susser M. Conception to birth — epidemiology of prenatal development. New York: Oxford University Press; 1989. [Google Scholar]
  74. Knox E.G., Armstrong E.H., Lancashire R. The quality of notification of congenital malformations. J Epidemiol Community Health. 1984;38(4):296–305. doi: 10.1136/jech.38.4.296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Kondo S., Schutte B.C., Richardson R.J., Bjork B.C., Knight A.S., Watanabe Y., Howard E., de Lima R.L., Daack-Hirsch S., Sander A., McDonald-McGinn D.M., Zackai E.H., Lammer E.J., Aylsworth A.S., Ardinger H.H., Lidral A.C., Pober B.R., Moreno L., Arcos-Burgos M., Valencia C., Houdayer C., Bahuau M., Moretti-Ferreira D., Richieri-Costa A., Dixon M.J., Murray J.C. Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. Nat Genet. 2002;32(2):285–289. doi: 10.1038/ng985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  76. Kramer M.S., Liu S., Luo Z., Yuan H., Platt R.W., Joseph K.S. Analysis of perinatal mortality and its components: time for a change? Am J Epidemiol. 2002;156(6):493–497. doi: 10.1093/aje/kwf077. [DOI] [PubMed] [Google Scholar]
  77. Li D.K., Wi S. Changing paternity and the risk of preeclampsia/eclampsia in the subsequent pregnancy. Am J Epidemiol. 2000;151(1):57–62. doi: 10.1093/oxfordjournals.aje.a010122. [DOI] [PubMed] [Google Scholar]
  78. Lie R.T., Rasmussen S., Brunborg H., Gjessing H.K., Lie-Nielsen E., Irgens L.M. Fetal and maternal contributions to risk of pre-eclampsia: population based study. BMJ. 1998;316(7141):1343–1347. doi: 10.1136/bmj.316.7141.1343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Linnet K.M., Dalsgaard S., Obel C., Wisborg K., Henriksen T.B., Rodriguez A., Kotimaa A., Moilanen I., Tomsen P.H., Olsen J., Jarvelin M.R. Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and assiocated behaviors: review of the current evidence. Am J Psychatry. 2003;160(6):1028–1040. doi: 10.1176/appi.ajp.160.6.1028. [DOI] [PubMed] [Google Scholar]
  80. Livingston J.C., Barton J.R., Park V., Haddad B., Phillips O., Sibai B.M. Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia. Am J Obstet Gynecol. 2001;185(1):153–157. doi: 10.1067/mob.2001.114691. [DOI] [PubMed] [Google Scholar]
  81. Longnecker M.P., Klebanoff M.A., Zhou H., Brock J.W. Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-for-gestational-age babies at birth. Lancet. 2001;358(9276):110–114. doi: 10.1016/S0140-6736(01)05329-6. [DOI] [PubMed] [Google Scholar]
  82. Ludwig M., Diedrich K. Follow-up of children born after assisted reproductive technologies. Reprod Biomed Online. 2002;5(3):317–322. doi: 10.1016/S1472-6483(10)61839-1. [DOI] [PubMed] [Google Scholar]
  83. Macklon N.S., Geraedts J.P., Fauser B.C. Conception to ongoing pregnancy: the ‘black box’ of early pregnancy loss. Hum Reprod Update. 2002;8(4):333–343. doi: 10.1093/humupd/8.4.333. [DOI] [PubMed] [Google Scholar]
  84. Maclure M. The case-crossover design: a method for studying transient effects on the risk of acute events. Am J Epidemiol. 1991;133(2):144–153. doi: 10.1093/oxfordjournals.aje.a115853. [DOI] [PubMed] [Google Scholar]
  85. Martin F.I., Ratnaike S., Wootton A., Condos P., Suter P.E. The 75 g oral glucose tolerance in pregnancy. Diabetes Res Clin Pract. 1995;27(2):147–151. doi: 10.1016/0168-8227(95)01035-C. [DOI] [PubMed] [Google Scholar]
  86. McCormack V.A., dos Silva I., De Stavola B.L., Mohsen R., Leon D.A., Lithell H.O. Fetal growth and subsequent risk of breast cancer: results from long term follow up of Swedish cohort. BMJ. 2003;326(7383):248. doi: 10.1136/bmj.326.7383.248. [DOI] [PMC free article] [PubMed] [Google Scholar]
  87. Mednick S.A., Huttunen M.O., Machon R.A. Prenatal influenza infections and adult schizophrenia. Schizophr Bull. 1994;20(2):263–267. doi: 10.1093/schbul/20.2.263. [DOI] [PubMed] [Google Scholar]
  88. Metz C.E. Basic principles of ROC analysis. Semin Nucl Med. 1978;8(4):283–298. doi: 10.1016/s0001-2998(78)80014-2. [DOI] [PubMed] [Google Scholar]
  89. Mitchell A.A., Cottler L.B., Shapiro S. Effect of questionniare design on recall of drug exposure in pregnancy. Am J Epidemiol. 1986;123(4):670–676. doi: 10.1093/oxfordjournals.aje.a114286. [DOI] [PubMed] [Google Scholar]
  90. Murphy D.J., Sellers S., MacKenzie I.Z., Yudkin P.L., Johnson A.M. Case-control study of antenatal and intrapartum risk factors for cerebral palsy in very preterm singleton babies. Lancet. 1995;346(8988):1449–1454. doi: 10.1016/S0140-6736(95)92471-X. [DOI] [PubMed] [Google Scholar]
  91. Ness R.B., Roberts J.M. Heterogeneous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications. Am J Obstet Gynecol. 1996;175(5):1365–1370. doi: 10.1016/S0002-9378(96)70056-X. [DOI] [PubMed] [Google Scholar]
  92. Andersen A.-M., Wohlfahrt J., Christens P., Olsen J., Melbye M. Maternal age and fetal loss: population based register linkage study. BMJ. 2000;320(7251):1708–1712. doi: 10.1136/bmj.320.7251.1708. [DOI] [PMC free article] [PubMed] [Google Scholar]
  93. Olsen J. Calculating risk ratios for spontaneous abortions: the problem of induced abortions. Int J Epidemiol. 1984;13(3):347–350. doi: 10.1093/ije/13.3.347. [DOI] [PubMed] [Google Scholar]
  94. Olsen J. Options in making use of pregnancy history in planning and analysing studies of reproductive failure. J Epidemiol Community Health. 1994;48(2):171–174. doi: 10.1136/jech.48.2.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  95. Olsen J. Prenatal exposures and long-term health effects. Epidemiol Rev. 2000;22(1):76–81. doi: 10.1093/oxfordjournals.epirev.a018028. [DOI] [PubMed] [Google Scholar]
  96. Olsen J., Andersen P.K. Accounting for pregnancy dependence in epidemiologic studies of pregnancy outcomes. Epidemiology. 1998;9(3):363–364. doi: 10.1097/00001648-199805000-00033. [DOI] [PubMed] [Google Scholar]
  97. Olsen J., Andersen P.K. We should monitor human fecundity, but how? A suggestion for a new method that may also be used to identify determinants of low fecundity. Epidemiology. 1999;10(4):419–421. doi: 10.1097/00001648-199907000-00013. [DOI] [PubMed] [Google Scholar]
  98. Olsen J., Basso O. Study design. In: Olsen J., Saracci R., Trichopoulos D., editors. Teaching epidemiology. A guide for teachers in epidemiology, public health and clinical medicine. 2 edn. New York: Oxford University Press; 2001. pp. 41–52. [Google Scholar]
  99. Olsen J., Basso O., Spinelli A., Küppers-Chinnow M., European Study Group on Infertility and Subfecundity Correlates of care seeking for infertility treatment in Europe. Eur J Public Health. 1998;8(1):15–20. doi: 10.1093/eurpub/8.1.15. [DOI] [Google Scholar]
  100. Olsen J., Czeizel A., Sorensen H.T., Nielsen G.L., van den Berg L.T.J., Irgens L.M., Olesen C., Pedersen L., Larsen H., Lie R.T., de Vries C.S., Bergman U. How do we best detect toxic effects of drugs taken during pregnancy? Drug Saf. 2002;25(1):21–32. doi: 10.2165/00002018-200225010-00003. [DOI] [PubMed] [Google Scholar]
  101. Olsen J., Juul S., Basso O. Measuring time to pregnancy. Methodological issues to consider. Hum Reprod. 1998;13(7):1751–1753. doi: 10.1093/humrep/13.7.1751. [DOI] [PubMed] [Google Scholar]
  102. Olsen J., Melbye M., Olsen S.F., Sorensen T.I., Aaby P., Andersen A.M., Taxbol D., Hansen K.D., Juhl M., Schow T.B., Sorensen H.T., Andresen J., Mortensen E.L., Olesen A.W., Sondergaard C. The Danish National Birth Cohort — its background, structure and aim. Scand J Public Health. 2001;29(4):300–307. doi: 10.1080/140349401317115268. [DOI] [PubMed] [Google Scholar]
  103. Olsen J., Rachootin P., Schiodt A.V., Damsbo N. Tobacco use, alcohol consumption and infertility. Int J Epidemiol. 1983;12(2):179–184. doi: 10.1093/ije/12.2.179. [DOI] [PubMed] [Google Scholar]
  104. Olsen J., Rachootin P. Invited commentary: monitoring fecundity over time — if we do it, then let’s do it right. Am J Epidemiol. 2003;157(2):94–97. doi: 10.1093/aje/kwf178. [DOI] [PubMed] [Google Scholar]
  105. Olsen J., Schmidt M.M., Christensen K. Evaluation of nature-nurture impact on reproductive health using half-siblings. Epidemiol. 1997;8(1):6–11. doi: 10.1097/00001648-199701000-00001. [DOI] [PubMed] [Google Scholar]
  106. Parker J.D., Schoendorf K.C. Implications of cleaning gestational age data. Paediatr Perinat Epidemiol. 2002;16(2):181–187. doi: 10.1046/j.1365-3016.2002.00407.x. [DOI] [PubMed] [Google Scholar]
  107. Pharoah P.O., Adi Y. Consequences of in-utero death in a twin pregnancy. Lancet. 2000;355(9215):1597–1602. doi: 10.1016/S0140-6736(00)02215-7. [DOI] [PubMed] [Google Scholar]
  108. Quenby S., Vince G., Farquharson R., Aplin J. Opinion. Recurrent miscarriage: a defect in nature’s quality control? Human Reprod. 2002;17(8):1959–1963. doi: 10.1093/humrep/17.8.1959. [DOI] [PubMed] [Google Scholar]
  109. Rachootin P., Olsen J. Prevalence and socioeconomic correlates of subfecundity and spontaneous abortion in Denmark. Int J Epidemiol. 1982;11(3):245–249. doi: 10.1093/ije/11.3.245. [DOI] [PubMed] [Google Scholar]
  110. Rachootin P., Olsen J. The risk of infertility and delayed conception associated with exposure in the Danish workplace. J Occup Med. 1983;25(5):394–402. [PubMed] [Google Scholar]
  111. Ravelli G.P., Stein Z.A., Susser M.W. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med. 1976;295(7):349–353. doi: 10.1056/NEJM197608122950701. [DOI] [PubMed] [Google Scholar]
  112. Roberts J.M., Cooper D.W. Pathogenesis and genetics of pre-eclampsia. Lancet. 2001;357(9249):53–56. doi: 10.1016/S0140-6736(00)03577-7. [DOI] [PubMed] [Google Scholar]
  113. Roberts J.M., Lain K.Y. Recent insights into the pathogenesis of pre-eclampsia. Placenta. 2002;23(5):359–372. doi: 10.1053/plac.2002.0819. [DOI] [PubMed] [Google Scholar]
  114. Robillard P.Y., Hulsey T.C., Perianin J., Janky E., Miri E.H., Papiernik E. Association of pregnancy-induced hypertension with duration of sexual cohabitation before conception. Lancet. 1994;344(8928):973–975. doi: 10.1016/S0140-6736(94)91638-1. [DOI] [PubMed] [Google Scholar]
  115. Rockenbauer M., Olsen J., Czeizel A.E., Pedersen L., Sorensen H.T. Recall bias in a case-control surveillance system on the use of medicine during pregnancy. Epidemiology. 2001;12(4):461–466. doi: 10.1097/00001648-200107000-00017. [DOI] [PubMed] [Google Scholar]
  116. Rothenberg S.J., Kondrashov V., Manalo M., Jiang J., Cuellar R., Garcia M., Reynoso B., Reyes S., Diaz M., Todd A.C. Increases in hypertension and blood pressure during pregnancy with increased bone lead levels. Am J Epidemiol. 2002;156(12):1079–1087. doi: 10.1093/aje/kwf163. [DOI] [PubMed] [Google Scholar]
  117. Russell I.T., Wilcox A.J. A criterion for low birthweight. Int J Epidemiol. 1991;20(4):1145. doi: 10.1093/ije/20.4.1145. [DOI] [PubMed] [Google Scholar]
  118. Sabroe S., Olsen J. Perinatal correlates of specific histological types of testicular cancer in patients below 35 years of age: a case-cohort study based on midwives’ records in Denmark. Int J Cancer. 1998;78(2):140–143. doi: 10.1002/(SICI)1097-0215(19981005)78:2<140::AID-IJC2>3.0.CO;2-Z. [DOI] [PubMed] [Google Scholar]
  119. Salas S.P. What causes pre-eclampsia? Baillieres Best Pract Res Clin Obstet Gynaecol. 1999;13(1):41–57. doi: 10.1053/beog.1999.0005. [DOI] [PubMed] [Google Scholar]
  120. Savitz D.A., Sonnenfeld N.L., Olshan A.F. Review of epidemiologic studies of paternal occupational exposure and spontaneous abortion. Am J Ind Med. 1994;25(3):361–383. doi: 10.1002/ajim.4700250306. [DOI] [PubMed] [Google Scholar]
  121. Schmidt M.I., Duncan B.B., Reichelt A.J., Branchtein L., Matos M.C., Forti A., Spichler E.R., Pousada J.M., Teixeira M.M., Yamashita T. Gestational diabetes mellitus diagnosed with a 2-h 75-g oral glucose tolerance test and adverse pregnancy outcomes. Diabetes Care. 2001;24(7):1151–1155. doi: 10.2337/diacare.24.7.1151. [DOI] [PubMed] [Google Scholar]
  122. Schmidt M.I., Matos M.C., Reichelt A.J., Forti A.C., de Lima L., Duncan B.B. Prevalence of gestational diabetes mellitus — do the new WHO criteria make a difference? Diabet Med. 2000;17(5):376–380. doi: 10.1046/j.1464-5491.2000.00257.x. [DOI] [PubMed] [Google Scholar]
  123. Sharpe R.M., Skakkebaek N.E. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet. 1993;341(8857):1392–1395. doi: 10.1016/0140-6736(93)90953-E. [DOI] [PubMed] [Google Scholar]
  124. Sibai B.M. Prevention of preeclampsia: a big disappointment. Am J Obstet Gynecol. 1998;179(5):1275–1278. doi: 10.1016/S0002-9378(98)70146-2. [DOI] [PubMed] [Google Scholar]
  125. Skjaerven R., Gjessing H.K., Bakketeig L.S. New standards for birth weight by gestational age using family data. Am J Obstet Gynecol. 2000;183(3):689–696. doi: 10.1067/mob.2000.106590. [DOI] [PubMed] [Google Scholar]
  126. Skjaerven R., Wilcox A.J., Lie R.T. The interval between pregnancies and the risk of preeclampsia. N Engl J Med. 2002;346(1):33–38. doi: 10.1056/NEJMoa011379. [DOI] [PubMed] [Google Scholar]
  127. Smith G.D., Ebrahim S. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease. Int J Epidemiol. 2003;32:1–22. doi: 10.1093/ije/dyg070. [DOI] [PubMed] [Google Scholar]
  128. Smoking or Health — the third Report from the Royal College of Physicians of London (1977) Pitman Medical Publishing, London
  129. Sondergaard C., Skajaa E., Henriksen T.B. Fetal growth and infantile colic. Arch Dis Child Fetal Neonatal Ed. 2000;83(1):F44–47. doi: 10.1136/fn.83.1.F44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  130. Stang A., Ahrens W., Bromen K., Baumgardt-Elms C., Jahn I., Stegmaier C., Krege S., Jöckel K.H. Undescended testis and the risk of testicular cancer, importance of source and classification of exposure information. Int J Epidemiol. 2001;30(5):1050–1056. doi: 10.1093/ije/30.5.1050. [DOI] [PubMed] [Google Scholar]
  131. Starr T., Levine R.J. Assessing effects of occupational exposure on fertility with indirect standardization. Am J Epidemiol. 1983;118(6):897–904. doi: 10.1093/oxfordjournals.aje.a113707. [DOI] [PubMed] [Google Scholar]
  132. Storgaard L., Bonde J.P., Ernst E., Andersen C.Y., Kyvik K.O., Olsen J. Effect of prenatal exposure to oestrogen on quality of semen: comparison of twins and singleton brothers. BMJ. 2002;325(7358):252–253. doi: 10.1136/bmj.325.7358.252. [DOI] [PMC free article] [PubMed] [Google Scholar]
  133. Strohsnitter W.C., Noller K.L., Hoover R.N., Robboy S.J., Palmer J.R., Titus-Ernstoff L., Kaufman R.H., Adam E., Herbst A.L., Hatch E.E. Cancer risk in men exposed in utero to diethylstilbestrol. J Natl Cancer Inst. 2001;93(7):545–551. doi: 10.1093/jnci/93.7.545. [DOI] [PubMed] [Google Scholar]
  134. Susser M., Stein Z. Timing in prenatal nutrition: a reprise of the Dutch Famine Study. Nutr Rev. 1994;52(3):84–94. doi: 10.1111/j.1753-4887.1994.tb01395.x. [DOI] [PubMed] [Google Scholar]
  135. Swan S.H., Shaw G.M., Schulman J. Reporting and selection bias in case-control studies of congenital malformations. Epidemiology. 1992;3(4):356–363. doi: 10.1097/00001648-199207000-00011. [DOI] [PubMed] [Google Scholar]
  136. Tong S., Caddy D., Short R.V. Use of dizygotic to monozygotic twinning ratio as a measure of fertility. Lancet. 1997;349(9055):843–845. doi: 10.1016/S0140-6736(96)10003-9. [DOI] [PubMed] [Google Scholar]
  137. Trichopoulos D. Hypothesis: does breast cancer originate in utero? Lancet. 1990;335(8695):939–940. doi: 10.1016/0140-6736(90)91000-Z. [DOI] [PubMed] [Google Scholar]
  138. Trogstad L.I., Eskild A., Magnus P., Samuelsen S.O., Nesheim B.I. Changing paternity and time since last pregnancy; the impact on pre-eclampsia risk. A study of 547,238 women with and without previous pre-eclampsia. Int J Epidemiol. 2001;30(6):1317–1322. doi: 10.1093/ije/30.6.1317. [DOI] [PubMed] [Google Scholar]
  139. Trupin L.S., Simon L.P., Eskenazi B. Change in paternity: a risk factor for preeclampsia in multiparas. Epidemiology. 1996;7(3):240–244. doi: 10.1097/00001648-199605000-00004. [DOI] [PubMed] [Google Scholar]
  140. Verdoux H., Geddes J.R., Takei N., Lawrie S.M., Bovet P., Eagles J.M., Heun R., McCreadie R.G., McNeil T.F., O’Callaghan E., Stober G., Willinger M.U., Wright P., Murray R.M. Obstetric complications and age at onset in schizophrenia: an international collaborative meta-analysis of individual patient data. Am J Psychiatry. 1997;154(9):1220–1227. doi: 10.1176/ajp.154.9.1220. [DOI] [PubMed] [Google Scholar]
  141. Vestergaard M., Basso O., Henriksen T.B., Oestergaard J.R., Olsen J. Risk factors for febrile convulsions. Epidemiol. 2002;13(3):282–287. doi: 10.1097/00001648-200205000-00008. [DOI] [PubMed] [Google Scholar]
  142. Villar J., Belizan J.M. Same nutrient, different hypotheses: disparities in trials of calcium supplementation during pregnancy. Am J Clin Nutr. 2000;71(5 Suppl):1375S–1379S. [PubMed] [Google Scholar]
  143. von Dadelszen P., Ornstein M.P., Bull S.B., Logan A.G., Koren G., Magee L.A. Fall in mean arterial pressure and fetal growth restriction in pregnancy hypertension: a meta-analysis. Lancet. 2000;355(9198):87–92. doi: 10.1016/S0140-6736(98)08049-0. [DOI] [PubMed] [Google Scholar]
  144. Weinberg C.R. Toward a clearer definition of confounding. Am J Epidemiol. 1993;137(1):1–8. doi: 10.1093/oxfordjournals.aje.a116591. [DOI] [PubMed] [Google Scholar]
  145. Weinberg C.R., Baird D.D., Wilcox A.J. Sources of bias in studies of time to pregnancy. Stat Med. 1994;13(5–7):671–681. doi: 10.1002/sim.4780130528. [DOI] [PubMed] [Google Scholar]
  146. Weinberg C.R., Baird D.D., Wilcox A.J. Bias in retrospective studies of spontaneous abortion based on the outcome of the most recent pregnancy. Ann N Y Acad Sci. 1994;18(709):280–286. doi: 10.1111/j.1749-6632.1994.tb30416.x. [DOI] [PubMed] [Google Scholar]
  147. Weinberg C.R., Wilcox A.J. Reproductive epidemiology. In: Rothman K.J., Greenland S., editors. Modern epidemiology. 2nd edn. Philadelphia, USA: Lippincott-Raven; 1998. [Google Scholar]
  148. Weinberg C.R., Wilcox A.J., Lie R.T. A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet. 1998;62(4):969–978. doi: 10.1086/301802. [DOI] [PMC free article] [PubMed] [Google Scholar]
  149. Wen S.W., Demissie K., Liu S., Marcoux S., Kramer M.S. Placenta praevia and male sex at birth: results from a population-based study. Paediatr Perinat Epidemiol. 2000;14(4):300–304. doi: 10.1046/j.1365-3016.2000.00280.x. [DOI] [PubMed] [Google Scholar]
  150. Whitacre C.C. Sex differences in autoimmune disease. Nat Immunol. 2001;2(9):777–780. doi: 10.1038/ni0901-777. [DOI] [PubMed] [Google Scholar]
  151. Whitacre C.C., Reingold S.C., O’Looney P.A. A gender gap in autoimmunity. Science. 1999;283(5406):1277–1278. doi: 10.1126/science.283.5406.1277. [DOI] [PubMed] [Google Scholar]
  152. Wilcox A.J. On the importance — and the unimportance — of birthweight. Int J Epidemiology. 2001;30(6):1233–1241. doi: 10.1093/ije/30.6.1233. [DOI] [PubMed] [Google Scholar]
  153. Wilcox A.J., Baird D.D., Weinberg C.R., Hornsby P.P., Herbst A.L. Fertility in men exposed prenatally to diethylstilbestrol. N Engl J Med. 1995;332(21):1411–1416. doi: 10.1056/NEJM199505253322104. [DOI] [PubMed] [Google Scholar]
  154. Wilcox A.J., Weinberg C.R., O’Connor J.F., Baird D.D., Schlatterer J.P., Canfield R.E., Armstrong E.G., Nisula B.C. Incidence of early loss of pregnancy. N Engl J Med. 1988;319(4):189–194. doi: 10.1056/NEJM198807283190401. [DOI] [PubMed] [Google Scholar]
  155. Winbo I.G., Serenius F.H., Dahlquist G.G., Kallen B.A. A computer-based method for cause of death classification in stillbirths and neonatal deaths. Int J Epidemiol. 1997;26(6):1298–1306. doi: 10.1093/ije/26.6.1298. [DOI] [PubMed] [Google Scholar]
  156. Zhang J., Cai W.W. Severe vomiting during pregnancy: antenatal correlates and fetal outcomes. Epidemiol. 1991;2(6):454–457. doi: 10.1097/00001648-199111000-00013. [DOI] [PubMed] [Google Scholar]
  157. Zweig M.H., Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem. 1993;39(4):561–577. [PubMed] [Google Scholar]

Textbooks in Reproductive Epidemiology

  1. Bracken M.B., editor. Perinatal epidemiology. New York: Oxford University Press; 1984. [Google Scholar]
  2. Kallen B. Epidemiology of human reproduction. Boca Raton: CRC Press; 1988. [Google Scholar]
  3. Keith L.G., Papiernik E., Keith D.M., Luke B., editors. Multiple pregnancy: epidemiology, gestation and perinatal outcome. 1st edn. New York: Parthenon Publishing Group; 1995. [Google Scholar]
  4. Kiely M., editor. Reproductive and perinatal epidemiology. Boca Raton: CRC Press; 1991. [Google Scholar]
  5. Kline J., Stein Z., Susser M. Monographs in Epidemiology and Biostatistics. New York: Oxford University Press; 1989. Conception to birth — epidemiology of prenatal development. [Google Scholar]
  6. McDowall M.E. Occupational reproductive epidemiology: the use of routinely collected statistics in England and Wales, 1980–82. London: Her Majesty’s Stationery Office; 1985. [Google Scholar]
  7. Murray CJL, Lopez AD (eds) (1988) Health dimensions of sex and reproduction. In: Global Burden of Disease and Injury Series, Vol III, 1998. WHO, Geneva

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