Abstract
Tracheobronchitis can be broadly defined as inflammation of the airways between the larynx and the bronchioles. Clinically, this syndrome is recognized by an increase in the volume and purulence of the lower respiratory tract secretions and is frequently associated with signs of variable airflow obstruction. In the intensive care unit (ICU), tracheobronchitis is a relatively common problem with an incidence as high as 10.6% [1]. Although tracheobronchitis is associated with a significantly longer length of ICU stay and a prolonged need for mechanical ventilation, it has not been shown to increase mortality. These outcomes can be improved through the use of antimicrobial agents [1].
Keywords: Chronic Obstructive Pulmonary Disease, Respiratory Syncytial Virus, Avian Influenza, Nosocomial Pneumonia, Adult Respiratory Distress Syndrome
References
- 1.Nseir S., DiPompeo C., Pronnier P., Beague S., Onimus T., et al. Nosocomial tracheobronchitis in mechanically ventilated patients: incidence, aetiology and outcome. Eur Respir J. 2002;20:1483–1489. doi: 10.1183/09031936.02.00012902. [DOI] [PubMed] [Google Scholar]
- 2.Torres A., El-Ebiary M., Rano A. Respiratory infectious complications in the intensive care unit. Clin Chest Med. 1999;20:287–301. doi: 10.1016/S0272-5231(05)70142-8. [DOI] [PubMed] [Google Scholar]
- 3.Craven D.E., Kunches L.M., Kilinsky V., Lichtenberg D.A., Make B.J., McCabe W.R. Risk factors for pneumonia and fatality in patients receiving continuous mechanical ventilation. Am Rev Respir Dis. 1986;133:792–6. [PubMed] [Google Scholar]
- 4.Adair C.G., Gorman S.P., Feron B.M., et al. Implications of endotracheal tube biofilm for ventilator-associated pneumonia. Intensive Care Med. 1999;25:1072–6. doi: 10.1007/s001340051014. [DOI] [PubMed] [Google Scholar]
- 5.Siegal M.D., Tocino I. Chest radiology in the intensive care unit. Clin Pulmon Med. 1999;6:347–355. doi: 10.1097/00045413-199911000-00004. [DOI] [Google Scholar]
- 6.Santos E., Talusan A., Brandestetter R.D. Radiographic mimics of pneumonia in the critical care unit. Crit Care Clin. 1998;14:91–104. doi: 10.1016/S0749-0704(05)70383-3. [DOI] [PubMed] [Google Scholar]
- 7.Niederman M.S., Craven D.E., Fein A.M., et al. Respiratory infection complicating long-term tracheostomy: the implication of persistent gram-negative tracheobronchial colonization. Chest. 1984;85:39–44. doi: 10.1378/chest.85.1.39. [DOI] [PubMed] [Google Scholar]
- 8.Johanson W.G., Pierce A.K., Sanford J.P., et al. Nosocomial respiratory infections with gram-negative bacilli. Ann Intern Med. 1972;77:701–706. doi: 10.7326/0003-4819-77-5-701. [DOI] [PubMed] [Google Scholar]
- 9.Örtqvest, Hammers-Berggren S., Kalin M. Respiratory tract colonization and incidence of secondary infection during hospital treatment of community-acquired pneumonia. Eur J Clin Microbiol Infect Dis. 1990;9:725–731. doi: 10.1007/BF02184684. [DOI] [PubMed] [Google Scholar]
- 10.Salata R.A., Ellner J.J. Bacterial colonization of the tracheobronchial tree. Clin Chest Med. 1988;91:623–633. [PubMed] [Google Scholar]
- 11.Harlid R., Andersson G., Frostell C.G., et al. Respiratory tract colonization and infection in patients with chronic tracheostomy: a one-year study in patients living at home. Am J Respir Crit Care Med. 1996;154:124–129. doi: 10.1164/ajrccm.154.1.8680667. [DOI] [PubMed] [Google Scholar]
- 12.Rogers R.M., Weiler C., Ruppenthal B. Impact of the respiratory intensive care unit on survival of patients with acute respiratory failure. Chest. 1972;62:94–97. doi: 10.1378/chest.62.1.94. [DOI] [PubMed] [Google Scholar]
- 13.Cross A.S., Roup B. Role of respiratory assistance devices in endemic nosocomial pneumonia. Am J Med. 1981;70:681–685. doi: 10.1016/0002-9343(81)90596-9. [DOI] [PubMed] [Google Scholar]
- 14.Niederman M.S., Ferranti R.D., Zeigler A., et al. Respiratory infection complicating long-term tracheostomy. Chest. 1984;85:39–44. doi: 10.1378/chest.85.1.39. [DOI] [PubMed] [Google Scholar]
- 15.Bartlett J.T., Faling L.J., Willey S. Quantitative tracheal bacteriological and cytologic studies in patients with long-term tracheostomies. Chest. 1978;74:635–639. doi: 10.1378/chest.74.6.635. [DOI] [PubMed] [Google Scholar]
- 16.Levine S.A., Niederman M.S. The impact of tracheal intubation on host defenses and risks for nosocomial pneumonia. Clin Chest Med. 1991;12(3):523–543. [PubMed] [Google Scholar]
- 17.Gal T.J. How does tracheal intubation alter respiratory mechanics? Probl Anesth. 1988;2:191–200. [Google Scholar]
- 18.Klainer A.S., Turndorf H., Wu W.H., et al. Surface alterations due to endotracheal intubation. Am J Med. 1975;58:674–683. doi: 10.1016/0002-9343(75)90504-5. [DOI] [PubMed] [Google Scholar]
- 19.Ramphal R., Guay P. Pseudomonas aeruginosa adhesions for tracheobronchial mucin. Infect Immun. 1987;55:600–603. doi: 10.1128/iai.55.3.600-603.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 20.Ramphal R., Pyle M. Adherence of mucoid and non-mucoid Pseudomonas aeruginosa to acid-injured tracheal epithelium. Infect Immun. 1983;41:345–31. doi: 10.1128/iai.41.1.345-351.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 21.Craven D.E., Goularte T.A., Make B.J. Contaminated condensate in mechanical ventilator circuits: a risk factor for nosocomial pneumonia. Am Rev Respir Dis. 1984;129:625–628. [PubMed] [Google Scholar]
- 22.Craven D.E., Lichtenberg D.A., Goularte T.A., et al. Contaminated medication nebulizers in mechanical ventilator circuits: source of bacterial aerosols. Am J Med. 1984;77:834–838. doi: 10.1016/0002-9343(84)90520-5. [DOI] [PubMed] [Google Scholar]
- 23.Schwartz S.N., Dowling J.N., Benkovic C., et al. Sources of gram-negative bacilli colonizing the trachea of intubated patients. J Infect Dis. 1978;138:227–231. doi: 10.1093/infdis/138.2.227. [DOI] [PubMed] [Google Scholar]
- 24.Niederman M.S., Mantovani R., Schoch P., et al. Patterns and routes of tracheobronchial colonization in mechanically ventilated patients: the role of nutritional status in colonization of the lower airway by Pseudomonas species. Chest. 1989;95:155–161. doi: 10.1378/chest.95.1.155. [DOI] [PubMed] [Google Scholar]
- 25.Johanson W.G., Jr, Pierce A.K., Sanford J.P., et al. Nosocomial respiratory infections with gram-negative bacilli: the significance of colonization of the respiratory tract. Ann Intern Med. 1972;77:701–706. doi: 10.7326/0003-4819-77-5-701. [DOI] [PubMed] [Google Scholar]
- 26.Nseir S., DiPompeo D., Soubrier S., Lenci H., Delour P., et al. Effect of ventilator-associated tracheobronchitis on outcome in patients without chronic respiratory failure: a case-control study. Crit Care. 2005;9:R238–245. doi: 10.1186/cc3508. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 27.Niederman M.S., Ferranti R.D., Ziegler A., et al. Respiratory infection complicating long-term tracheostomy: The implication of persistent gram-negative tracheobronchial colonization. Chest. 1984;85:39–44. doi: 10.1378/chest.85.1.39. [DOI] [PubMed] [Google Scholar]
- 28.George D.L., Falk P.S., Wunderink R.G., et al. Epidemiology of ventilator-acquired pneumonia based on protected bronchoscopic sampling. Am J Respir Crit Care Med. 1998;158:1839–1847. doi: 10.1164/ajrccm.158.6.9610069. [DOI] [PubMed] [Google Scholar]
- 29.Namba Y., Mihara N., Tanaka M. Fulminant tracheobronchitis caused by methicillin-resistant Staphylococcus aureus (MRSA) Jpn J Thoracic Dis. 1997;35(9):969–973. [PubMed] [Google Scholar]
- 30.Yamazaki Y., Hirai K., Honda T. Pseudomembranous tracheobronchitis caused by methicillin-resistant Staphylococcus aureus. Scand J Infect Dis. 2002;34:211–213. doi: 10.1080/00365540110077083. [DOI] [PubMed] [Google Scholar]
- 31.Cefai C., Richards J., Gould F.K., et al. An outbreak of Acinetobacter respiratory tract infection resulting from incomplete disinfection of ventilatory equipment. J Hosp Infect. 1990;15:177–182. doi: 10.1016/0195-6701(90)90128-B. [DOI] [PubMed] [Google Scholar]
- 32.Seifert H., Strate A., Pulverer G. Nosocomial bacteremia due to Acinetobacter baumannii: Clinical features, epidemiology, and predictors of mortality. Medicine. 1995;74(6):340–349. doi: 10.1097/00005792-199511000-00004. [DOI] [PubMed] [Google Scholar]
- 33.Seifert H., Baginski R., Schulze A., et al. Antimicrobial susceptibility of Acinetobacter species. Antimicrob Agents Chemother. 1993;37:750–753. doi: 10.1128/aac.37.4.750. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 34.Chen Y.C., Chang S.C., Hsieh W.C., et al. Acinetobacter calcoaceticus bacteremia: analysis of 48 cases. J Formosan Med Assoc. 1991;90:958–963. [PubMed] [Google Scholar]
- 35.Leigh M.W., Clyde W.A. Chlamydial and mycoplasmal pneumonias. Semin Respir Infect. 1987;2:152–158. [PubMed] [Google Scholar]
- 36.Rose R.M., Pinkston P., O’Donnell C., et al. Viral infection of the lower respiratory tract. Clin Chest Med. 1987;8:405–418. [PubMed] [Google Scholar]
- 37.Glezen W.P., Loda F.A., Clyde W.A., et al. Epidemiologic patterns of acute lower respiratory disease of children in a pediatric practice. J Pediatr. 1971;78:397–406. doi: 10.1016/S0022-3476(71)80218-4. [DOI] [PubMed] [Google Scholar]
- 38.Fischman R.A., Marschall K.E., Kislak J.W., et al. Adult respiratory distress syndrome caused by Mycoplasma pneumonia. Chest. 1978;74:471–473. doi: 10.1378/chest.74.4.471. [DOI] [PubMed] [Google Scholar]
- 39.Zack M.B., Kazemi H. Carbon dioxide retention in Mycoplasma pneumonia. Am Rev Respir Dis. 1973;107:1052–1054. doi: 10.1164/arrd.1973.107.6.1052. [DOI] [PubMed] [Google Scholar]
- 40.Chang S.M., Kuo H.T., Lin F.J., Tzen C.Y., Sheu C.Y. Pseudomembranous tracheobronchitis caused by Aspergillus in immunocompromised patients. Scand J Infect Dis. 2005;37:937–942. doi: 10.1080/00365540510044445. [DOI] [PubMed] [Google Scholar]
- 41.Routsi C., Kaltsas P., Bessis E., Rontogianni D., Kollias S., Roussos C. Airway obstruction and acute respiratory failure due to Aspergillus tracheobronchitis. Crit Care Med. 2004;32:580–582. doi: 10.1097/01.CCM.0000110724.86196.3B. [DOI] [PubMed] [Google Scholar]
- 42.Routsi C., Platsouka E., Prekates A., Rontogianni D., Paniara O., Roussos C. Aspergillus bronchitis causing atelectasis and acute respiratory failure in an immunocompromised patient. Infection. 2001;29:243–244. doi: 10.1007/s15010-001-1148-0. [DOI] [PubMed] [Google Scholar]
- 43.Clarke A., Skelton J., Fraser R.S. Fungal tracheobronchitis: report of 9 cases and review of the literature. Medicine. 1991;70(1):1–14. doi: 10.1097/00005792-199101000-00001. [DOI] [PubMed] [Google Scholar]
- 44.Meyer R.D., Young L.S., Armstrong D., et al. Aspergillosis complicating neoplastic disease. Am J Med. 1973;54:6–15. doi: 10.1016/0002-9343(73)90077-6. [DOI] [PubMed] [Google Scholar]
- 45.Orr D.P., Myerowitz R.L., Dubois P.J. Patho-radiologic correlation of invasive pulmonary aspergillosis in the compromised host. Cancer. 1978;41:2028–2039. doi: 10.1002/1097-0142(197805)41:5<2028::AID-CNCR2820410551>3.0.CO;2-#. [DOI] [PubMed] [Google Scholar]
- 46.Young R.C., Bennett J.E., Vogel C.L., et al. Aspergillosis. The spectrum of the disease of 98 patients. Medicine. 1970;49:149–173. doi: 10.1097/00005792-197003000-00002. [DOI] [PubMed] [Google Scholar]
- 47.Dubois P.J., Myerowitz R.L., Allen C.M. Pathoradiologic correlation of pulmonary candidiasis in immunosuppressed patients. Cancer. 1977;40:1026–1036. doi: 10.1002/1097-0142(197709)40:3<1026::AID-CNCR2820400310>3.0.CO;2-G. [DOI] [PubMed] [Google Scholar]
- 48.Chakravarty S.C. Bronchopulmonary candidiasis: Clinical aspects. Dis Chest. 1967;51:608–613. doi: 10.1378/chest.51.6.608. [DOI] [PubMed] [Google Scholar]
- 49.Wengrower D., Or R., Segal E., Kleinman Y. Bronchopulmonary candidiasis exacerbating asthma. Case report and a review of the literature. Respiration. 1985;47:209–213. doi: 10.1159/000194771. [DOI] [PubMed] [Google Scholar]
- 50.Azoulay E., Timsit J.-F., Tafflet M., et al. Candida colonization of the respiratory tract and subsequent Pseudomonas ventilator-associated pneumonia. Chest. 2006;29:110–117. doi: 10.1378/chest.129.1.110. [DOI] [PubMed] [Google Scholar]
- 51.Tasci S., Glasmacher A., Lentini S., Tschubel K., Ewig S., Molitor E., Sauerbruch T., Luderitz B., Rabe C. Pseudomembranous and obstructive Aspergillus tracheobronchitis — optimal diagnostic strategy and outcome. Mycoses. 2006;49:37–42. doi: 10.1111/j.1439-0507.2005.01180.x. [DOI] [PubMed] [Google Scholar]
- 52.Kramer M.R., Denning D.W., Marshall S.E., et al. Ulcerative tracheobronchitis after lung transplantation: a new form of invasive aspergillosis. Am Rev Respir Dis. 1991;144:552–556. doi: 10.1164/ajrccm/144.3_Pt_1.552. [DOI] [PubMed] [Google Scholar]
- 53.Gerson S.L., Talbot G.H., Hurwitz S., et al. Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia. Ann Intern Med. 1984;100:345–351. doi: 10.7326/0003-4819-100-3-345. [DOI] [PubMed] [Google Scholar]
- 54.Lehrer R.I., Cline M.J. Leukocyte candidacidal activity and resistance to systemic candidiasis in patients with cancer. Cancer. 1971;27:1211–1217. doi: 10.1002/1097-0142(197105)27:5<1211::AID-CNCR2820270528>3.0.CO;2-3. [DOI] [PubMed] [Google Scholar]
- 55.Dale D.C., Petersdorf R.G. Corticosteroids and infectious diseases. Med Clin North Am. 1973;57:1277–1287. doi: 10.1016/s0025-7125(16)32228-3. [DOI] [PubMed] [Google Scholar]
- 56.Bodey G.P. Candidiasis in cancer patients. Am J Med. 1984;77(Suppl 4D):13–19. [PubMed] [Google Scholar]
- 57.Denny F.W., Jr The clinical impact of human respiratory virus infections. Am J Respir Crit Care Med. 1995;152:S4. doi: 10.1164/ajrccm/152.4_Pt_2.S4. [DOI] [PubMed] [Google Scholar]
- 58.Ellenbogen C., Graybill J.L., Silva J., et al. Bacterial pneumonia complicating viral pneumonia. Am J Med. 1974;56:169–178. doi: 10.1016/0002-9343(74)90594-4. [DOI] [PubMed] [Google Scholar]
- 59.Wong S.S.Y., Yuen K. Avian influenza virus infection in humans. Chest. 2006;129:156–168. doi: 10.1378/chest.129.1.156. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 60.Frank A.L., Taber L.H., Wells C.R., et al. Patterns of shedding of myxoviruses and paramyxoviruses in children. J Infect Dis. 1981;144:433–441. doi: 10.1093/infdis/144.5.433. [DOI] [PubMed] [Google Scholar]
- 61.Hall C.B. Respiratory syncytial virus and parainfluenza virus. N Engl J Med. 2001;344:1917–1928. doi: 10.1056/NEJM200106213442507. [DOI] [PubMed] [Google Scholar]
- 62.Kark J.D., Lebiush M., Rannon L. Cigarette smoking as a risk factor for epidemic A(H1N1) influenza in young men. N Engl J Med. 1982;307:1042–1046. doi: 10.1056/NEJM198210213071702. [DOI] [PubMed] [Google Scholar]
- 63.Mullooly J.P., Barker W.H., Nolan T.F., Jr Risk of acute respiratory disease among pregnant women during influenza A epidemics. Public Health Rep. 1986;101:205–211. [PMC free article] [PubMed] [Google Scholar]
- 64.Conway S.P., Simmonds E.J., Littlewood J.M. Acute severe deterioration in cystic fibrosis associated with influenza A virus infection. Thorax. 1992;47:112–114. doi: 10.1136/thx.47.2.112. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 65.Ungchusak K., Auewarkul P., Dowell S.F., et al. Probable person-to-person transmission of Avian influenza A (H5N1) N Engl J Med. 2005;352:333–340. doi: 10.1056/NEJMoa044021. [DOI] [PubMed] [Google Scholar]
- 66.O’Brien T.G., Sweeney D.F. Interstitial viral pneumonitis complicated by severe respiratory failure: successful management using intensive dehydration and steroids. Chest. 1973;63:314–232. doi: 10.1378/chest.63.3.314. [DOI] [PubMed] [Google Scholar]
- 67.Roberts G.B.S. Fulminating influenza. Lancet. 1957;2:944. doi: 10.1016/S0140-6736(57)92400-5. [DOI] [Google Scholar]
- 68.Winther B., Brofeldt S., Gronborg H., et al. Study of bacteria in the nasal cavity and nasopharynx during naturally acquired common cold. Acta Otolaryngol. 1984;98:315–320. doi: 10.3109/00016488409107569. [DOI] [PubMed] [Google Scholar]
- 69.Tran T.H., Nguyen T.L., Nguyen T.D., et al. Avian influenza A (H5N1) in 10 patients in Vietnam. N Engl J Med. 2004;350:1179–1188. doi: 10.1056/NEJMoa040419. [DOI] [PubMed] [Google Scholar]
- 70.Chotpitayasunondh T., Ungchusak K., Hanshaoworatal, et al. Human disease from influenza A (H5N1) Emerg Infect Dis. 2005;11:201–209. doi: 10.3201/eid1102.041061. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 71.Rapid diagnostic tests for influenza The Medical Letter. 1999;41:121–122. [PubMed] [Google Scholar]
- 72.Calfee D.P., Hayden F.G. New approaches to influenza chemotherapy. Neuraminidase inhibitors. Drugs. 1998;56:537–553. doi: 10.2165/00003495-199856040-00003. [DOI] [PubMed] [Google Scholar]
- 73.Smith C.B., Kanner R.E., Golden C.A., et al. Effect of viral infection on pulmonary function in patients with chronic obstructive pulmonary diseases. J Infect Dis. 1980;141:271–280. doi: 10.1093/infdis/141.3.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 74.Bateman E.D., Hayashi S., Kuwano K., et al. Latent adenoviral infection in follicular bronchiectasis. Am J Respir Crit Care Med. 1995;151:170–176. doi: 10.1164/ajrccm.151.1.7812549. [DOI] [PubMed] [Google Scholar]
- 75.Morales F., Calder M.A., Inglis J.M., et al. A study of respiratory infections in the elderly to assess the role of respiratory syncytial virus. J Infect. 1983;7:236–247. doi: 10.1016/S0163-4453(83)97142-6. [DOI] [PubMed] [Google Scholar]
- 76.Falsey A.R., Hennessey P.A., Formica M.A., et al. Respiratory syncytial virus infection in elderly and high-risk adults. N Eng J Med. 2005;352:1749–1759. doi: 10.1056/NEJMoa043951. [DOI] [PubMed] [Google Scholar]
- 77.Englund J.A., Piedra P.A., Jewell A., Patel K., Baxter B.B., Whimbey E. Rapid diagnosis of respiratory syncytial virus infection in immunocompromised adults. J Clin Microbiol. 1996;34:1649–1653. doi: 10.1128/jcm.34.7.1649-1653.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 87.Morgan H.R., Finland M. Isolation of herpes virus from a case of atypical pneumonia and erythema multiforme exudativum: with studies of four additional cases. Am J Med Sci. 1949;217:92–95. doi: 10.1097/00000441-194901000-00011. [DOI] [PubMed] [Google Scholar]
- 79.Stern H., Elek S.D., Millar D.M., Anderson H.F. Herpetic whitlow: a form of cross-infection in hospitals. Lancet. 1959;2:871–874. doi: 10.1016/S0140-6736(59)90804-9. [DOI] [PubMed] [Google Scholar]
- 80.Lheureux P., Verhest A., Vincent J.L., Liénard C., Levivier M., Kahn R.J. Herpes virus infection, an unusual source of adult respiratory distress syndrome. Eur J Respir Dis. 1985;67:72–77. [PubMed] [Google Scholar]
- 81.Benjamin D. Herpes simplex tracheobronchitis and pneumonitis. Pediatr Pathol. 1989;9:773–777. doi: 10.3109/15513818909022386. [DOI] [PubMed] [Google Scholar]
- 82.Nash G., Foley F.D. Herpetic infection of the middle and lower respiratory tract. Am J Clin Pathol. 1970;54:857–863. doi: 10.1093/ajcp/54.6.857. [DOI] [PubMed] [Google Scholar]
- 83.Ramsey P.G., Fife K.H., Hackman R.C., Mayers J.D., Corey L. Herpes simplex virus pneumonia: clinical, virologic, and pathologic features in 20 patients. Ann Intern Med. 1982;97:813–820. doi: 10.7326/0003-4819-97-6-813. [DOI] [PubMed] [Google Scholar]
- 84.Frable W.J., Frable M.A., Seney F.D., Jr Virus infections of the respiratory tract: cytopathologic and clinical analysis. Acta Cytol. 1977;21:32–36. [PubMed] [Google Scholar]
- 85.Tuxen D.V., Wilson J.W., Cade J.F. Prevention of lower respiratory herpes simplex virus infection with acyclovir in patients with the adult respiratory distress syndrome. Am Rev Respir Dis. 1987;136:402–405. doi: 10.1164/ajrccm/136.2.402. [DOI] [PubMed] [Google Scholar]
- 86.Tuxen D.V., Cade J.F., McDonald M.I., Buchanan M.R., Clark R.J., Pain M.C. Herpes simplex virus from the lower respiratory tract in adult respiratory distress syndrome. Am Rev Respir Dis. 1982;126:416–419. doi: 10.1164/arrd.1982.126.3.416. [DOI] [PubMed] [Google Scholar]
- 87.Prellner T., Flamholc L., Haidl S., Lindholm K., Widell A. Herpes simplex virus — the most frequently isolated pathogen in the lungs of patients with severe respiratory distress. Scand J Infect Dis. 1992;24:283–292. doi: 10.3109/00365549209061333. [DOI] [PubMed] [Google Scholar]
- 88.Sherry M.K., Klainer A.S., Wolff M., Gerhard H. Herpetic tracheobronchitis. Ann Intern Med. 1988;109:229–233. doi: 10.7326/0003-4819-109-3-229. [DOI] [PubMed] [Google Scholar]
- 89.Legge R.H., Thompson A.B., Linder J., Woods G.L., Robbins R.A., Moulton A.L., et al. Acyclovir-responsive herpetic tracheobronchitis. Am J Med. 1988;85:516–563. doi: 10.1016/S0002-9343(88)80098-6. [DOI] [PubMed] [Google Scholar]
- 90.Chakraborty A., Forker A., Reese H., Casey J. Tracheobronchitis and pneumonia due to herpes simplex virus (HSV) infection. Nebr Med J. 1988;73:347–350. [PubMed] [Google Scholar]
- 91.Vaxelaire J.F., Brunet F., Armaganidis A., Pochard F., Giraud T., Lanore J.J., et al. The role of herpes simplex virus in respiratory complications after cardiac surgery. Am Rev Respir Dis. 1991;143:A474. [Google Scholar]
- 92.Porteous C., Bradley J.A., Hamilton D.N., Ledingham I.M., Clements G.B., Robinson C.G. Herpes simplex virus reactivation in surgical patients. Crit Care Med. 1984;12:626–628. doi: 10.1097/00003246-198408000-00003. [DOI] [PubMed] [Google Scholar]
- 93.Avery R.K., Longworth D.L. Viral pulmonary infections in thoracic and cardiovascular surgery. Semin Thoracic Cardiovasc Surg. 1995;7:88–94. [PubMed] [Google Scholar]
- 94.Cook C.H., Yenchar J.K., Kraner T.O., Davis E.A., Ferguson R.M. Occult herpes family viruses may increase mortality in critically ill surgical patients. Am J Surg. 1998;176:357–360. doi: 10.1016/S0002-9610(98)00205-0. [DOI] [PubMed] [Google Scholar]
- 95.St. John R.C., Pacht E.R. Tracheal stenosis and failure to wean from mechanical ventilation due to herpetic tracheitis. Chest. 1990;98:1520–2152. doi: 10.1378/chest.98.6.1520. [DOI] [PubMed] [Google Scholar]
- 96.Corey L., Spear P.G. Infections with herpes simplex viruses. N Engl J Med. 1986;314:749–757. doi: 10.1056/NEJM198603203141205. [DOI] [PubMed] [Google Scholar]
- 97.Nash G. Necrotizing tracheobronchitis and bronchopneumonia consistent with herpetic infection. Hum Pathol. 1972;3:283–291. doi: 10.1016/S0046-8177(72)80082-0. [DOI] [PubMed] [Google Scholar]
- 98.Graham B.S., Snell J.D., Jr Herpes simplex virus infection of the adult lower respiratory tract. Medicine. 1983;62:384–393. doi: 10.1097/00005792-198311000-00004. [DOI] [PubMed] [Google Scholar]
- 99.Herout V., Vortel V., Vondrackova A. Herpes simplex involvement of the lower respiratory tract. Am J Clin Pathol. 1966;46:411–419. doi: 10.1093/ajcp/46.4.411. [DOI] [PubMed] [Google Scholar]
- 100.Schuller D., Spessert C., Fraser V.J., Goodenberger D.M. Herpes simplex virus from respiratory tract secretions: epidemiology, clinical characteristics, and outcome in immunocompromised and nonimmunocompromised hosts. Am J Med. 1993;94:29–33. doi: 10.1016/0002-9343(93)90116-7. [DOI] [PubMed] [Google Scholar]
- 101.Perl T.M., Haugen T.H., Pfaller M.A., Hollis R., Lakeman A.D., Whitley R.J., et al. Transmission of herpes simplex virus type 1 infection in an intensive care unit. Ann Intern Med. 1992;117:584–586. doi: 10.7326/0003-4819-117-7-584. [DOI] [PubMed] [Google Scholar]
- 102.Papazian L., Fraisse L., et al. Cytomegalovirus. An unexpected cause of ventilator-associated pneumonia. Anesthesiology. 1996;84:280–287. doi: 10.1097/00000542-199602000-00005. [DOI] [PubMed] [Google Scholar]
- 103.Domart Y., Trouillet J.L., Fagan J.Y., Chastre J., Brun-Vezinet F., Gilbert C. Incidence and morbidity of cytomegaloviral infection in patients with mediastinitis following cardiac surgery. Chest. 1990;97:18–22. doi: 10.1378/chest.97.1.18. [DOI] [PubMed] [Google Scholar]
- 104.Cushing D., et al. Herpes simplex virus and cytomegalovirus excretion associated with increased ventilator days in trauma patients. J Trauma. 1993;35:161. [Google Scholar]
