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. 2005:329–351. doi: 10.1007/978-1-59259-976-9_15

Novel Natural Products From Rainforest Endophytes

Gary Strobel 4, Bryn Daisy 4, Uvidelio Castillo 4
Editors: Lixin Zhang1,2, Arnold L Demain3
PMCID: PMC7120694

Abstract

Endophytic microorganisms are found in virtually every higher plant on earth. These organisms reside in the living tissues of the host plant and do so in a variety of relationships, ranging from symbiotic to pathogenic. Endophytes may contribute to their host plant by producing a plethora of substances that provide protection and survival value to the plant. Ultimately, these compounds, once isolated and characterized, may also have potential for use in modern medicine. Novel antibiotics, antimycotics, immunosuppressants, and anticancer compounds are only a few examples of what has been found after the isolation and culturing of individual endophytes followed by purification and characterization of some of their natural products. The potential of finding new drugs that may be effective candidates for treating newly developing diseases in humans is great.

Key Words: Munumbicins, Kakadumycin, Taxol, volatile antibiotics, streptomycetes, anticancer agents, immunosuppressants

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