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. 2009;187:155–186. doi: 10.1007/978-3-540-79842-2_8

Peripheral Mechanisms II: The Pharmacology of Peripherally Active Antitussive Drugs

D Spina 3, I McFadzean 3, FKR Bertram 3, C P Page 3
Editors: Kian Fan Chung1, John Widdicombe2
PMCID: PMC7122788  PMID: 18825340

Abstract

Cough is an indispensable defensive reflex. Although generally beneficial, it is also a common symptom of diseases such as asthma, chronic obstructive pulmonary disease, upper respiratory tract infections, idiopathic pulmonary fibrosis and lung cancer. Cough remains a major unmet medical need and although the centrally acting opioids have remained the antitussive of choice for decades, they have many unwanted side effects. However, new research into the behaviour of airway sensory nerves has provided greater insight into the mechanisms of cough and new avenues for the discovery of novel non-opioid antitussive drugs. In this review, the pathophysiological mechanisms of cough and the development of novel antitussive drugs are reviewed.

Keywords: Chronic Cough, Cough Response, Antitussive Effect, Cough Sensitivity, Antitussive Agent

Contributor Information

Kian Fan Chung, Email: f.chung@imperial.ac.uk.

John Widdicombe, Email: JohnWiddicombeJ@aol.com.

C. P. Page, Email: clive.page@kcl.ac.uk

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