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. 2006;581:449–454. doi: 10.1007/978-0-387-33012-9_81

Efficacy of an Inactivated PRRSV Vaccine: Induction of Virus-Neutralizing Antibodies and Partial Virological Protection upon Challenge

Gerald Misinzo 3, Peter L Delputte 4, Peter Meerts 5, Christa Drexler 6, Hans J Nauwynck 7
Editors: Stanley Perlman1, Kathryn V Holmes2
PMCID: PMC7122804  PMID: 17037577

The content is available as a PDF (969.3 KB).

Contributor Information

Stanley Perlman, Email: Stanley-Perlman@uiowa.edu

Kathryn V. Holmes, Email: Kathryn.Holmes@ucHSC.edu

References

  • 1.Cavanagh D. Nidovirales: a new order comprising Coronaviridae and Arteriviridae. Arch. Virol. 1997;142:629–633. [PubMed] [Google Scholar]
  • 2.Plagemann PGW. Lactate dehydrogenase-elevating virus and related viruses. In: Knipe BN, Howley DMPM, editors. Fields Virology. Philadelphia: Lippincott-Raven; 1996. pp. 1105–1120. [Google Scholar]
  • 3.Duan X, Nauwynck HJ, Pensaert MB. Effects of origin and state of differentiation and activation of monocytes/macrophages on their susceptibility to PRRSV. Arch. Virol. 1997;142:2483–2497. doi: 10.1007/s007050050256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Vanderheijden N, Delputte PL, et al. Involvement of sialoadhesin in entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages. J. Virol. 2003;77:8207–8215. doi: 10.1128/JVI.77.15.8207-8215.2003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Kim HS, Kwang J, et al. Enhanced replication of porcine reproductive and respiratory syndrome (PRRS) virus in homogeneous subpopulation of MA-104 cell-line. Arch. Virol. 1993;133:477–483. doi: 10.1007/BF01313785. [DOI] [PubMed] [Google Scholar]
  • 6.Delputte PL, Vanderheijden N, Nauwynck HJ, Pensaert MB. Involvement of the matrix protein in attachment of porcine reproductive and respiratory syndrome virus to a heparin-like receptor on porcine alveolar macrophages. J. Virol. 2002;76:4312–4320. doi: 10.1128/JVI.76.9.4312-4320.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Delputte PL, Nauwynck HJ. Porcine arterivirus infection of alveolar macrophages is mediated by sialic acid on the virus. J. Virol. 2004;78:8094–8101. doi: 10.1128/JVI.78.15.8094-8101.2004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Collins JE, Benfield DA, et al. Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs. J. Vet. Diagn. Invest. 1992;4:117–126. doi: 10.1177/104063879200400201. [DOI] [PubMed] [Google Scholar]
  • 9.Meulenberg JJM, Hulst MM, et al. Lelystad virus belongs to a new virus family, comprising lactate dehydrogenase-elevating virus, equine arteritis virus, and simian hemorrhagic fever virus. Arch. Virol. 1994;9:441–448. doi: 10.1007/978-3-7091-9326-6_43. [DOI] [PubMed] [Google Scholar]
  • 10.Nielsen TL, Nielsen J, Have P, Baekbo P, Hoff-Jorgensen R, Bøtner A. Examination of virus shedding in semen from vaccinated and from previously infected boars after experimental challenge with porcine reproductive and respiratory syndrome virus. Vet. Microbiol. 1997;54:101–112. doi: 10.1016/S0378-1135(96)01272-2. [DOI] [PubMed] [Google Scholar]
  • 11.Plana-Duran J, Bastons M, Urniza A, Vayreda M, Vila X, Mane H. Efficacy of an inactivated vaccine for prevention of reproductive failure induced by porcine reproductive and respiratory syndrome virus. Vet. Microbiol. 1997;55:361–370. doi: 10.1016/S0378-1135(96)01317-X. [DOI] [PubMed] [Google Scholar]
  • 12.Nilubol D, Platt KB, Halbur PG, Torremorell M, Harris DL. The effect of a killed porcine reproductive and respiratory syndrome virus (PRRSV) vaccine treatment on virus shedding in previously PRRSV infected pigs. Vet. Microbiol. 2004;102:11–18. doi: 10.1016/j.vetmic.2004.05.006. [DOI] [PubMed] [Google Scholar]
  • 13.Labarque G, Van Gucht S, et al. Respiratory tract protection upon challenge of pigs vaccinated with attenuated porcine reproductive and respiratory syndrome virus vaccines. Vet. Microbiol. 2003;95:187–197. doi: 10.1016/S0378-1135(03)00157-3. [DOI] [PubMed] [Google Scholar]
  • 14.van Woensel PA, Liefkens K, Demaret S. Effect on viraemia of an American and a European serotype PRRSV vaccine after challenge with European wild-type strains of the virus. Vet. Rec. 1998;142:510–512. doi: 10.1136/vr.142.19.510. [DOI] [PubMed] [Google Scholar]
  • 15.Labarque G, Reeth KV, et al. Impact of genetic diversity of European-type porcine reproductive and respiratory syndrome virus strains on vaccine efficacy. Vaccine. 2004;22:4183–4190. doi: 10.1016/j.vaccine.2004.05.008. [DOI] [PubMed] [Google Scholar]
  • 16.Lager KM, Mengeling WL, Brockmeier SL. Evaluation of protective immunity in gilts inoculated with the NADC-8 isolate of porcine reproductive and respiratory syndrome virus (PRRSV) and challenge-exposed with an antigenically distinct PRRSV isolate. Am. J. Vet. Res. 1999;60:1022–1027. [PubMed] [Google Scholar]
  • 17.Nielsen HS, Oleksiewicz MB, et al. Reversion of a live porcine reproductive and respiratory syndrome virus vaccine investigated by parallel mutations. J. Gen. Virol. 2001;82:1263–1272. doi: 10.1099/0022-1317-82-6-1263. [DOI] [PubMed] [Google Scholar]
  • 18.Delputte PL, Meerts P, Costers S, Nauwynck HJ. Effect of virus-specific antibodies on attachment, internalization and infection of porcine reproductive and respiratory syndrome virus in primary macrophages. Vet. Immunol. Immunopathol. 2004;102:179–188. doi: 10.1016/j.vetimm.2004.09.007. [DOI] [PubMed] [Google Scholar]
  • 19.Labarque GG, Nauwynck HJ, Van Reeth K, Pensaert MB. Effect of cellular changes and onset of humoral immunity on the replication of porcine reproductive and respiratory syndrome virus in the lungs of pigs. J. Gen. Virol. 2000;81:1327–1334. doi: 10.1099/0022-1317-81-5-1327. [DOI] [PubMed] [Google Scholar]
  • 20.Osorio FA, Galeota JA, et al. Passive transfer of virus-specific antibodies confers protection against reproductive failure induced by a virulent strain of porcine reproductive and respiratory syndrome virus and establishes sterilizing immunity. Virology. 2002;302:9–20. doi: 10.1006/viro.2002.1612. [DOI] [PubMed] [Google Scholar]

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