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. 2012 Mar 3;724:1–14. doi: 10.1007/978-1-4614-0653-2_1

Acuted Disseminated Encephalomyelitis

Joy B Parrish 2,✉, E Ann Yeh 2
Editor: Shamim I Ahmad1
PMCID: PMC7123244  PMID: 22411230

Abstract

Acute disseminated encephalomyelitis (ADEM) is a disorder of the central nervous system (CNS) characterized by an acute event, typically with encephalopathy, in which diffuse CNS involvement occurs. It may follow an infectious event and occurs more commonly in young children. Pulse steroid treatment is frequently used to treat ADEM. Although ADEM is typically described as a benign condition, with children generally recovering motor function and resolution of lesions on magnetic resonance imaging (MRI), residual cognitive deficits may occur. This chapter aims to review the clinical features, typical presentation, differential diagnosis, treatment and prognosis of ADEM.

Keywords: Multiple Sclerosis, Neurodegenerative Disease, Optic Neuritis, Borrelia Burgdorferi, Therapeutic Plasma Exchange

References

  • 1.Schwarz S, Mohr A, Knauth M, et al. Acute disseminated encephalomyelitis: A follow-up study of 40 adult patients. Neurology. 2001;56:1313–1318. doi: 10.1212/wnl.56.10.1313. [DOI] [PubMed] [Google Scholar]
  • 2.Tenembaum S, Cahamoles N, Fejerman N. Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients. Neurology. 2002;59(8):1224–1231. doi: 10.1212/wnl.59.8.1224. [DOI] [PubMed] [Google Scholar]
  • 3.Krupp LB, Banwell B, Tenembaum S. Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology. 2007;68(16 Suppl 2):S7–S12. doi: 10.1212/01.wnl.0000259422.44235.a8. [DOI] [PubMed] [Google Scholar]
  • 4.McKeon A, Lennon VA, Lotze T, et al. CNS aquaporin-4 autoimmunity in children. Neurology. 2008;71(2):93–100. doi: 10.1212/01.wnl.0000314832.24682.c6. [DOI] [PubMed] [Google Scholar]
  • 5.Alper G, Heyman R, Wang L. Multiple sclerosis and acute disseminated encephalomyelitis diagnosed in children after long-term follow-up: Comparison of presenting features. Developmental Medicine and Child Neurology. 2009;51:480–486. doi: 10.1111/j.1469-8749.2008.03136.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Pohl D, Rostasy K, Reiber H, Hanefeld F. CSF characteristics in early-onset multiple sclerosis. Neurology. 2004;63(10):1966–1967. doi: 10.1212/01.wnl.0000144352.67102.bc. [DOI] [PubMed] [Google Scholar]
  • 7.Dale RC, de Sousa C, Chong WK, et al. Acute disseminated encephalomylitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain. 2000;12:2407–2422. doi: 10.1093/brain/123.12.2407. [DOI] [PubMed] [Google Scholar]
  • 8.Anlar B, Basaran C, Kose G, et al. Acute disseminated encephalomyelitis in children: outcome and prognosis. Neuropediatrics. 2003;34(4):194–199. doi: 10.1055/s-2003-42208. [DOI] [PubMed] [Google Scholar]
  • 9.Leake JA, Albani S, Kao AS, et al. Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory features. Pediatr Infect Dis J. 2004;23(8):756–764. doi: 10.1097/01.inf.0000133048.75452.dd. [DOI] [PubMed] [Google Scholar]
  • 10.Mikaeloff Y, Caridade G, Husson B, et al. Acute disseminated encephalomyelitis cohort study: prognostic factors for relapse. Eur J Paediatr Neurol. 2007;11(2):90–95. doi: 10.1016/j.ejpn.2006.11.007. [DOI] [PubMed] [Google Scholar]
  • 11.Olgac Dundar N, Anlar B, Guven A et al. Relapsing Acute Disseminated Encephalomyelitis in Children: Further Evaluation of the Diagnosis. J Child Neurol 2010; [Epub ahead of print] [DOI] [PubMed]
  • 12.Banwell B, Kennedy J, Sadovnick D, et al. Incidence of acquired demyelination of the CNS in Canadian children. Neurology. 2009;72(3):232–239. doi: 10.1212/01.wnl.0000339482.84392.bd. [DOI] [PubMed] [Google Scholar]
  • 13.Tenembaum SN. Disseminated encephalomyelitis in children. Clin Neurol Neurosurg. 2008;110(9):928–938. doi: 10.1016/j.clineuro.2007.12.018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Torisu H, Kira R, Ishizaki Y, et al. Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis and acute transverse myelitis in Fukuoka Prefecture, Japan. Brain and Development. 2010;32:454–462. doi: 10.1016/j.braindev.2009.10.006. [DOI] [PubMed] [Google Scholar]
  • 15.Tenembaum S, Chitnis T, Ness J, et al. Acute disseminated encephalomyelitis. Neurology. 2007;68(16 Suppl 2):S23–S36. doi: 10.1212/01.wnl.0000259404.51352.7f. [DOI] [PubMed] [Google Scholar]
  • 16.Tenembaum S. Disseminated encephalomyelitis in children. Clinical Neurology and Neurosurgery. 2008;110:928–938. doi: 10.1016/j.clineuro.2007.12.018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Atzori M, Battistella PA, Perini P, et al. Clinical and diagnostic aspects of multiple sclerosis and acute monophasic encephalomyelitis in pediatric patients: A single centre prospective study. Mult Sclerosis. 2009;15:363–370. doi: 10.1177/1352458508098562. [DOI] [PubMed] [Google Scholar]
  • 18.Murthy KSN, Faden HS, Cohen ME et al. Acute disseminated encephalomyelitis in children. Pediatrics 2002; 110(2). [DOI] [PubMed]
  • 19.Hynson JL, Kornberg AJ, Coleman LT, et al. Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children. Neurology. 2001;56(10):1308–1312. doi: 10.1212/wnl.56.10.1308. [DOI] [PubMed] [Google Scholar]
  • 20.Gupte G, Stonehouse M, Wassmer E, et al. Acute disseminated encephalomyelitis: a review of 18 cases in childhood. J Paediatr Child Health. 2003;39(5):336–342. doi: 10.1046/j.1440-1754.2003.00154.x. [DOI] [PubMed] [Google Scholar]
  • 21.Mikaeloff Y, Suissa S, Vallee L, et al. First episode of acute CNS inflammatory demyelination in childhood: prognostic factors for multiple sclerosis and disability. J Pediatr. 2004;144(2):246–252. doi: 10.1016/j.jpeds.2003.10.056. [DOI] [PubMed] [Google Scholar]
  • 22.Schwarz S, Mohr A, Knauth M, et al. Acute disseminated encephalomyelitis: a follow-up study of 40 adult patients. Neurology. 2001;56(10):1313–1318. doi: 10.1212/wnl.56.10.1313. [DOI] [PubMed] [Google Scholar]
  • 23.Marchioni E, Tavazzi E, Minoli L, et al. Acute disseminated encephalomyelitis. Neurol Sci. 2008;29:S286–S288. doi: 10.1007/s10072-008-0966-6. [DOI] [PubMed] [Google Scholar]
  • 24.Sonneville R, Demeret S, Klein I, et al. Acute disseminated encephalomyelitisin the intensive care unit:clinical features and outcome of 20 adults. Intensive Care Med. 2008;34(3):528–532. doi: 10.1007/s00134-007-0926-2. [DOI] [PubMed] [Google Scholar]
  • 25.Sonneville R, Klein I, de Broucker T, et al. Post-infectious encephalitis in adults: diagnosis and management. J Infect. 2009;58(5):321–328. doi: 10.1016/j.jinf.2009.02.011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26.Axer H, Ragoschke-Schumm A, Bottcher J, et al. Initial DWI and ADC imaging may predict outcome in acute disseminated encephalomyelitis: report of two cases of brain stem encephalitis. J Neurol Neurosurg Psychiatry. 2005;76(7):996–998. doi: 10.1136/jnnp.2004.045500. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Menge T, Kiesseier BC, Nessler S, et al. Acute disseminated encephalomyelitis: an acute hit against the brain. Curr Opin Neurol. 2007;20:247–254. doi: 10.1097/WCO.0b013e3280f31b45. [DOI] [PubMed] [Google Scholar]
  • 28.Booss J, Davis LE. Smallpox and smallpox vaccination: neurological implications. Neurology. 2003;60(8):1241–1245. doi: 10.1212/01.wnl.0000063319.64515.6b. [DOI] [PubMed] [Google Scholar]
  • 29.Sejvar JJ, Labutta RJ, Chapman LE, et al. Neurologic adverse events associated with smallpox vaccination in the United States, 2002-2004. JAMA. 2005;294(21):2744–2750. doi: 10.1001/jama.294.21.2744. [DOI] [PubMed] [Google Scholar]
  • 30.Bennetto L, Scolding N. Inflammatory/post-infectious encephalomyelitis. J Neurol Neurosurg Psychiatry 2004; (75 Suppl 1):i22–i28. [DOI] [PMC free article] [PubMed]
  • 31.Fenichel GM. Neurological complications of immunization. Ann Neurol. 1982;12(2):119–128. doi: 10.1002/ana.410120202. [DOI] [PubMed] [Google Scholar]
  • 32.Nalin DR. Mumps, measles and rubella vaccination and encephalitis. BMJ. 1989;299(6709):1219. doi: 10.1136/bmj.299.6709.1219-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 33.Plesner AM. Arlien-Soborg P, Herning M. Neurological complications to vaccination against Japanese encephalitis. Eur J Neurol. 1998;5(5):479–485. doi: 10.1046/j.1468-1331.1998.550479.x. [DOI] [PubMed] [Google Scholar]
  • 34.Cheong JH, Bak KH, Kim CH, et al. Acute disseminated encephalomyelitis associated with influenza vaccination. J Korean Neurosurg Soc. 2004;35:223–225. [Google Scholar]
  • 35.Izurieta HS, Haber P, Wise RP, et al. Adverse events reported following live, cold-adapted, intranasal influenza vaccine. JAMA. 2005;294(21):2720–2725. doi: 10.1001/jama.294.21.2720. [DOI] [PubMed] [Google Scholar]
  • 36.Dodick DW, Silber MH, Noseworthy JH, et al. Acute disseminated encephalomyelitis after accidental injection of a hog vaccine: successful treatment with plasmapheresis. Mayo Clin Proc. 1998;73(12):1193–1195. doi: 10.4065/73.12.1193. [DOI] [PubMed] [Google Scholar]
  • 37.Sonmez FM, Odemis E, Ahmetoglu A, et al. Brainstem encephalitis and acute disseminated encephalomyelitis following mumps. Pediatr Neurol. 2004;30(2):132–134. doi: 10.1016/j.pediatrneurol.2003.09.004. [DOI] [PubMed] [Google Scholar]
  • 38.Miller DH, Kay R, Schon F, et al. Optic neuritis following chickenpox in adults. J Neurol. 1986;233(3):182–184. doi: 10.1007/BF00314431. [DOI] [PubMed] [Google Scholar]
  • 39.Fujimoto H, Asaoka K, Imaizumi T, et al. Epstein-Barr virus infections of the central nervous system. Intern Med. 2003;42(1):33–40. doi: 10.2169/internalmedicine.42.33. [DOI] [PubMed] [Google Scholar]
  • 40.Revel-Vilk S, Hurvitz H, Klar A, et al. Recurrent acute disseminated encephalomyelitis associated with acute cytomegalovirus and Epstein-Barr virus infection. J Child Neurol. 2000;15(6):421–424. doi: 10.1177/088307380001500614. [DOI] [PubMed] [Google Scholar]
  • 41.Kaji M, Kusuhara T, Ayabe M, et al. Survey of herpes simplex virus infections of the central nervous system, including acute disseminated encephalomyelitis, in the Kyushu and Okinawa regions of Japan. Mult Scler. 1996;2(2):83–87. doi: 10.1177/135245859600200204. [DOI] [PubMed] [Google Scholar]
  • 42.Sacconi S, Salviati L, Merelli E. Acute disseminated encephalomyelitis associated with hepatitis C virus infection. Arch Neurol. 2001;58(10):1679–1681. doi: 10.1001/archneur.58.10.1679. [DOI] [PubMed] [Google Scholar]
  • 43.Tan H, Kilicaslan B, Onbas O, et al. Acute disseminated encephalomyelitis following hepatitis A virus infection. Pediatr Neurol. 2004;30(3):207–209. doi: 10.1016/j.pediatrneurol.2003.08.007. [DOI] [PubMed] [Google Scholar]
  • 44.David P, Baleriaux D, Bank WO, et al. MRI of acute disseminated encephalomyelitis after coxsackie B infection. J Neuroradiol. 1993;20(4):258–265. [PubMed] [Google Scholar]
  • 45.Wang YH, Huang YC, Chang LY, et al. Clinical characteristics of children with influenza A virus infection requiring hospitalization. J Microbiol Immunol Infect. 2003;36(2):111–116. [PubMed] [Google Scholar]
  • 46.Rellosa N, Bloch KC, Shane AL et al. Neurologic Manifestations of Pediatric Novel H1n1 Influenza Infection. Pediatr Infect Dis J. [DOI] [PubMed]
  • 47.Silver B, McAvoy K, Mikesell S, et al. Fulminating encephalopathy with perivenular demyelination and vacuolar myelopathy as the initial presentation of human immunodeficiency virus infection. Arch Neurol. 1997;54(5):647–650. doi: 10.1001/archneur.1997.00550170115023. [DOI] [PubMed] [Google Scholar]
  • 48.Tachi N, Watanabe T, Wakai S, et al. Acute disseminated encephalomyelitis following HTLV-I associated myelopathy. J Neurol Sci. 1992;110(1-2):234–235. doi: 10.1016/0022-510X(92)90034-I. [DOI] [PubMed] [Google Scholar]
  • 49.Kamei A, Ichinohe S, Onuma R, et al. Acute disseminated demyelination due to primary human herpesvirus-6 infection. Eur J Pediatr. 1997;156(9):709–712. doi: 10.1007/s004310050695. [DOI] [PubMed] [Google Scholar]
  • 50.Wei TY, Baumann RJ. Acute disseminated encephalomyelitis after Rocky Mountain spotted fever. Pediatr Neurol. 1999;21(1):503–505. doi: 10.1016/S0887-8994(99)00028-4. [DOI] [PubMed] [Google Scholar]
  • 51.Yeh EA, Collins A, Cohen ME, et al. Detection of coronavirus in the central nervous system of a child with acute disseminated encephalomyelitis. Pediatrics. 2004;113(1 Pt 1):e73–e76. doi: 10.1542/peds.113.1.e73. [DOI] [PubMed] [Google Scholar]
  • 52.Riedel K, Kempf VA, Bechtold A, et al. Acute disseminated encephalomyelitis (ADEM) due to Mycoplasma pneumoniae infection in an adolescent. Infection. 2001;29(4):240–242. doi: 10.1007/s15010-001-1173-z. [DOI] [PubMed] [Google Scholar]
  • 53.van Assen S, Bosma F, Staals LM, et al. Acute disseminated encephalomyelitis associated with Borrelia burgdorferi. J Neurol. 2004;251(5):626–629. doi: 10.1007/s00415-004-0415-2. [DOI] [PubMed] [Google Scholar]
  • 54.Nasralla CA, Pay N, Goodpasture HC, et al. Postinfectious encephalopathy in a child following Campylobacter jejuni enteritis. AJNR Am J Neuroradiol. 1993;14(2):444–448. [PMC free article] [PubMed] [Google Scholar]
  • 55.Lelis SS, Fonseca LF, Xavier CC, et al. Acute disseminated encephalomyelitis after leptospirosis. Pediatric Neurology. 2009;40(6):471–473. doi: 10.1016/j.pediatrneurol.2008.12.006. [DOI] [PubMed] [Google Scholar]
  • 56.Chandra SR, Kalpana D, Anilkumar TV, et al. Acute disseminated encephalomyelitis following leptospirosis. J Assoc Physicians India. 2004;52:327–329. [PubMed] [Google Scholar]
  • 57.Heick A, Skriver E. Chlamydia pneumoniae-associated ADEM. Eur J Neurol. 2000;7(4):435–438. doi: 10.1046/j.1468-1331.2000.00090.x. [DOI] [PubMed] [Google Scholar]
  • 58.Spieker S, Petersen D, Rolfs A, et al. Acute disseminated encephalomyelitis following Pontiac fever. Eur Neurol. 1998;40(3):169–172. doi: 10.1159/000007975. [DOI] [PubMed] [Google Scholar]
  • 59.Dale RC, Church AJ, Cardoso F, et al. Poststreptococcal acute disseminated encephalomyelitis with basal ganglia involvement and auto-reactive antibasal ganglia antibodies. Ann Neurol. 2001;50(5):588–595. doi: 10.1002/ana.1250. [DOI] [PubMed] [Google Scholar]
  • 60.Huynh W, Cordato DJ, Kehdi E, et al. Post-vaccination encephalomyelitis: Literature review and illustrative case. Journal of Clinical Neuroscience. 2008;15:1315–1322. doi: 10.1016/j.jocn.2008.05.002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 61.Au WY, Lie AK, Cheung RT, et al. Acute disseminated encephalomyelitis after para-influenza infection post bone marrow transplantation. Leuk Lymphoma. 2002;43(2):455–457. doi: 10.1080/10428190290006350. [DOI] [PubMed] [Google Scholar]
  • 62.Horowitz MB, Comey C, Hirsch W, et al. Acute disseminated encephalomyelitis (ADEM) or ADEM-like inflammatory changes in a heart-lung transplant recipient: a case report. Neuroradiology. 1995;37(6):434–437. doi: 10.1007/BF00600082. [DOI] [PubMed] [Google Scholar]
  • 63.Re A, Giachetti R. Acute disseminated encephalomyelitis (ADEM) after autologous peripheral blood stem cell transplant for non-Hodgkin’s lymphoma. Bone Marrow Transplant. 1999;24(12):1351–1354. doi: 10.1038/sj.bmt.1702047. [DOI] [PubMed] [Google Scholar]
  • 64.Tomonari A, Tojo A, Adachi D, et al. Acute disseminated encephalomyelitis (ADEM) after allogeneic bone marrow transplantation for acute myeloid leukemia. Ann Hematol. 2003;82(1):37–40. doi: 10.1007/s00277-002-0573-1. [DOI] [PubMed] [Google Scholar]
  • 65.Jaster JH, Niell HB, Dohan FJ, et al. Demyelination in the brain as a paraneoplastic disorder: candidates include some cases of leukemia and non-Hodgkin’s lymphoma. Ann Hematol. 2003;82(11):714–715. doi: 10.1007/s00277-003-0761-7. [DOI] [PubMed] [Google Scholar]
  • 66.Mikaeloff Y, Caridade G, Suissa S, et al. Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood. Neurology. 2008;72(10):873–80. doi: 10.1212/01.wnl.0000335762.42177.07. [DOI] [PubMed] [Google Scholar]
  • 67.Belman A, Chabas D, Chitnis T et al. Clinical Spectrum of Disorders Masquerading as Pediatric Multiple Sclerosis. Annals of Neurology 2007; Supplement: Abstracts CNS.
  • 68.van der Knaap MS, Salomons GS, Li R, et al. Unusual variants of Alexander’s disease. Ann Neurol. 2005;57(3):327–338. doi: 10.1002/ana.20381. [DOI] [PubMed] [Google Scholar]
  • 69.Harris MO, Walsh LE, Hattab EM et al. Is it ADEM, POLG, or both? Arch Neurol 67(4):493–496. [DOI] [PubMed]
  • 70.Gorman MP, Golomb MR, Walsh LE, et al. Steroid-responsive neurologic relapses in a child with a proteolipid protein-1 mutation. Neurology. 2007;68(16):1305–1307. doi: 10.1212/01.wnl.0000259522.49388.53. [DOI] [PubMed] [Google Scholar]
  • 71.Weinstock A, Giglio P, Cohen ME, et al. Diffuse magnetic resonance imaging white-matter changes in a 15-year-old boy with mitochondrial encephalomyopathy. J Child Neurol. 2002;17(1):47–49. doi: 10.1177/088307380201700112. [DOI] [PubMed] [Google Scholar]
  • 72.van der Knaap MS, Valk J, de Neeling N, et al. Pattern recognition in magnetic resonance imaging of white matter disorders in children and young adults. Neuroradiology. 1991;33(6):478–493. doi: 10.1007/BF00588038. [DOI] [PubMed] [Google Scholar]
  • 73.Lotze TE, Northrop JL, Hutton GJ, et al. Spectrum of pediatric neuromyelitis optica. Pediatrics. 2008;122(5):e1039–e1047. doi: 10.1542/peds.2007-2758. [DOI] [PubMed] [Google Scholar]
  • 74.Mikaeloff Y, Adamsbaum C, Husson B, et al. MRI prognostic factors for relapse after acute CNS inflammatory demyelination in childhood. Brain. 2004;127(Pt 9):1942–1947. doi: 10.1093/brain/awh218. [DOI] [PubMed] [Google Scholar]
  • 75.Parrish JB, Weinstock-Guttman B, Yeh EA. Cerebellar mutism in pediatric acute disseminated encephalomyelitis. Pediatr Neurol. 2010;42(4):259–266. doi: 10.1016/j.pediatrneurol.2009.11.003. [DOI] [PubMed] [Google Scholar]
  • 76.Neuteboom RF, Boon M, Catsman BC, et al. Prognostic factors after a first attack of inflammatory CNS demyelination in children. Neurology. 2008;71(13):967–973. doi: 10.1212/01.wnl.0000316193.89691.e1. [DOI] [PubMed] [Google Scholar]
  • 77.Callen DJ, Shroff MM, Branson HM et al. Role of MRI in the differentiation of ADEM from MS in children. Neurology 2008. [DOI] [PubMed]
  • 78.Ketelslegers IA, Neuteboom RF, Boon M, et al. A comparison of MRI criteria for diagnosing pediatric ADEM and MS. Neurology. 2010;74(18):1412–5. doi: 10.1212/WNL.0b013e3181dc138b. [DOI] [PubMed] [Google Scholar]
  • 79.Chabas D, Ness J, Belman A, et al. Younger children with pediatric MS have a distinct CSF inflammatory profile at disease onset. Neurology. 2010;74(5):399–405. doi: 10.1212/WNL.0b013e3181ce5db0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 80.Selter RC, Brilot F, Grummel V, et al. Antibody responses to EBV and native MOG in pediatric inflammatory demyelinating CNS diseases. Neurology. 2010;74(21):1711–1715. doi: 10.1212/WNL.0b013e3181e04096. [DOI] [PubMed] [Google Scholar]
  • 81.Banwell B, Tenembaum S, Lennon VA, et al. Neuromyelitis optica-IgG in childhood inflammatory demyelinating CNS disorders. Neurology. 2008;70(5):344–352. doi: 10.1212/01.wnl.0000284600.80782.d5. [DOI] [PubMed] [Google Scholar]
  • 82.Kotlus BS, Slavin ML, Guthrie DS, et al. Ophthalmologic manifestations in pediatric patients with acute disseminated encephalomyelitis. J AAPOS. 2005;9(2):179–183. doi: 10.1016/j.jaapos.2004.10.009. [DOI] [PubMed] [Google Scholar]
  • 83.Simone IL, Carrara D, Tortorella C, et al. Course and prognosis in early-onset MS: comparison with adult-onset forms. Neurology. 2002;59(12):1922–1928. doi: 10.1212/01.wnl.0000036907.37650.8e. [DOI] [PubMed] [Google Scholar]
  • 84.Pohl D, Rostasy K, Treiber-Held S, et al. Pediatric multiple sclerosis: detection of clinically silent lesions by multimodal evoked potentials. J Pediatr. 2006;149(1):125–127. doi: 10.1016/j.jpeds.2006.01.003. [DOI] [PubMed] [Google Scholar]
  • 85.Frohman E, Costello F, Zivadinov R, et al. Optical coherence tomography in multiple sclerosis. Lancet Neurol. 2006;5(10):853–863. doi: 10.1016/S1474-4422(06)70573-7. [DOI] [PubMed] [Google Scholar]
  • 86.Yeh E, Weinstock-Guttman B, Lincoff N, et al. Retinal nerve fiber thickness in inflammatory demyelinating diseases of childhood onset. Mult Scler. 2009;15(7):802–810. doi: 10.1177/1352458509104586. [DOI] [PubMed] [Google Scholar]
  • 87.Hollinger P, Sturzenegger M, Mathis J, et al. Acute disseminated encephalomyelitis in adults: a reappraisal of clinical, CSF, EEG and MRI findings. J Neurol. 2001;249:320–329. doi: 10.1007/s004150200012. [DOI] [PubMed] [Google Scholar]
  • 88.Shahar E, Andraus J, Savitzki D, et al. Outcome of severe encephalomyelitis in children: effect of high-dose methylprednisolone and immunoglobulins. J Child Neurol. 2002;17(11):810–814. doi: 10.1177/08830738020170111001. [DOI] [PubMed] [Google Scholar]
  • 89.Khurana DS, Melvin JJ, Kothare SV, et al. Acute disseminated encephalomyelitis in children: discordant neurologic and neuroimaging abnormalities and response to plasmapheresis. Pediatrics. 2005;116(2):431–436. doi: 10.1542/peds.2004-2038. [DOI] [PubMed] [Google Scholar]
  • 90.Ravaglia S, Piccolo G, Ceroni M, et al. Severe steroid-resistant post-infectious encephalomyelitis: general features and effects of IVIg. J Neurol. 2007;254(11):1518–1523. doi: 10.1007/s00415-007-0561-4. [DOI] [PubMed] [Google Scholar]
  • 91.Straussberg R, Schonfeld T, Weitz R, et al. Improvement of atypical acute disseminated encephalomyelitis with steroids and intravenous immunoglobulins. Pediatr Neurol. 2001;24(2):139–143. doi: 10.1016/S0887-8994(00)00229-0. [DOI] [PubMed] [Google Scholar]
  • 92.Kaynar L, Altuntas F, Aydogdu I, et al. Therapeutic plasma exchange in patients with neurologic diseases: retrospective multicenter study. Transfus Apher Sci. 2008;38(2):109–115. doi: 10.1016/j.transci.2007.11.002. [DOI] [PubMed] [Google Scholar]
  • 93.Suppiej A, Vittorini R, Fontanin M, et al. Acute disseminated encephalomyelitis in chidlren: Focus on Relapsing Patients. Pediatr Neurol. 2008;39:12–17. doi: 10.1016/j.pediatrneurol.2008.03.009. [DOI] [PubMed] [Google Scholar]
  • 94.Tenembaum S, Chitnis T, Ness J, et al. Acute disseminated encephalomyelitis. Neurology. 2007;68(Suppl 2):S23–S36. doi: 10.1212/01.wnl.0000259404.51352.7f. [DOI] [PubMed] [Google Scholar]
  • 95.Jacobs RK, Anderson VA, Neale JL, et al. Neuropsychological outcome after acute disseminated encephalomyelitis: impact of age at illness onset. Pediatr Neurol. 2004;31(3):191–197. doi: 10.1016/j.pediatrneurol.2004.03.008. [DOI] [PubMed] [Google Scholar]
  • 96.Deery B, Anderson V, Jacobs R, et al. Childhood MS and ADEM: Investigation and comparison of neurocognitive features in children. Developmental Neuropsychology. 2010;35(5):506–521. doi: 10.1080/87565641.2010.494921. [DOI] [PubMed] [Google Scholar]
  • 97.Hahn CD, Miles BS, MacGregor DL, et al. Neurocognitive outcome after acute disseminated encephalomyelitis. Pediatr Neurol. 2003;29:117–123. doi: 10.1016/S0887-8994(03)00143-7. [DOI] [PubMed] [Google Scholar]

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