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. 2006;581:25–30. doi: 10.1007/978-0-387-33012-9_3

A Previously Unrecognized Unr Stem-Loop Structure in the Coronavirus 5’ Untranslated Region Plays a Functional role in Replication

Pinghua Liu 3, Jason J Millership 4, Lichun Li 5, David P Giedroc 6, Julian L Leibowitz 7
Editors: Stanley Perlman1, Kathryn V Holmes2
PMCID: PMC7123367  PMID: 17037499

The content is available as a PDF (961.5 KB).

Contributor Information

Stanley Perlman, Email: Stanley-Perlman@uiowa.edu

Kathryn V. Holmes, Email: Kathryn.Holmes@ucHSC.edu

References

  • 1.Chang R-Y, Hofmann MA, Sethna PB, Brian DA. A cis-acting function for the coronavirus leader in defective interfering RNA replication. J. Virol. 1994;68:8223–8231. doi: 10.1128/jvi.68.12.8223-8231.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Kim Y, Jeong YS, Makino S. Analysis of cis-acting sequences essential for coronavirus defective interfering RNA replication. Virology. 1993;197:53–63. doi: 10.1006/viro.1993.1566. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Raman S, Bouma P, Williams GD, Brian DA. Stem-loop III in the 5' untranslated region is a cis-acting element in bovine coronavirus defective interfering RNA replication. J. Virol. 2003;77:6720–6730. doi: 10.1128/JVI.77.12.6720-6730.2003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Hofacker IL. Vienna RNA secondary structure server. Nucleic Acids Res. 2003;31:3429–3431. doi: 10.1093/nar/gkg599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Yount B, Denison MR, Weiss SR, Baric RS. Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59. J. Virol. 2002;76:11065–11078. doi: 10.1128/JVI.76.21.11065-11078.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.R. F. Johnson, M. Feng, P. Liu, J. J. Millership, B. Yount, R. S. Baric, and J. L. Leibowitz, The effect of mutations in the mouse hepatitis virus 3'(+)42 protein binding element on RNA replication, J. Virol. (in press). [DOI] [PMC free article] [PubMed]
  • 7.Chang R-Y, Krishnan R, Brian DA. The UCUAAAC promoter motif is not required for high-frequency leader recombination in bovine coronavirus defective interfering RNA. J. Virol. 1996;70:2720–2729. doi: 10.1128/jvi.70.5.2720-2729.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Gutell RR, Cannone JJ, Konings D, Gautheret D. Predicting U-turns in ribosomal RNA with comparative sequence analysis. J. Mol. Biol. 2000;300:791–803. doi: 10.1006/jmbi.2000.3900. [DOI] [PubMed] [Google Scholar]

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