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. 2013 Oct 5:539–586. [Article in German] doi: 10.1007/978-3-642-34827-3_27

Obstruktive Atemwegserkrankungen

U Frey 5, M Gappa 6, E Eber 7, E von Mutius 8, J Barben 9, J Hammer 10, E Hamelmann 11, E Horak 12, A Schuster 13, G Hansen 14, J Seidenberg 15, M Modl 16
Editors: Erika von Mutius1, Monika Gappa2, Ernst Eber3, Urs Frey4
PMCID: PMC7123435

Zusammenfassung

In den folgenden Abschnitten werden die verschiedenen Formen der obstruktiven Atemwegserkrankungen erläutert, die je nach Alter, prädisponierenden Risikofaktoren und auch je nach Art der Auslöser verschiedenartige Ausprägungen und Verlaufsformen (Phänotypen) annehmen können.

Literatur

Einführung

  1. Brand PL, Baraldi E, Bisgaard H. Definition, assessment and treatment of wheezing disorders in preschool children: an evidencebased approach. Eur Respir J. 2008;32(4):1096–1110. doi: 10.1183/09031936.00002108. [DOI] [PubMed] [Google Scholar]
  2. Frey U, Suki B. Complexity of chronic asthma and chronic obstructive pulmonary disease: implications for risk assessment, and disease progression and control. Lancet. 2008;20(9643):1088–99. doi: 10.1016/S0140-6736(08)61450-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Frey U. von Mutius E. The challenge of managing wheezing in infants. N Engl J Med. 2009;360:2130–2133. doi: 10.1056/NEJMe0902242. [DOI] [PubMed] [Google Scholar]

Akute virale Bronchiolitis

  1. American Academy of Pediatrics Diagnosis and management of bronchiolitis. Pediatrics. 2006;118:1774–1793. doi: 10.1542/peds.2006-2223. [DOI] [PubMed] [Google Scholar]
  2. Barben J, Hammer J. Behandlung der Bronchiolitis im Suglingsalter - Empfehlungen der SAPP Paediatrica 2003; 14: 18–21
  3. Barben J, Kuehni CE, Trachsel D, Hammer J. Management of acute bronchiolitis: Can evidence-based guidelines alter clinical practice? Thorax. 2008;63(12):1103–1109. doi: 10.1136/thx.2007.094706. [DOI] [PubMed] [Google Scholar]
  4. Calogero C, Sly P. Acute virale bronchiolitis: To treat or not to treat - that is the question. J Pediatr. 2007;151(3):235–237. doi: 10.1016/j.jpeds.2007.05.041. [DOI] [PubMed] [Google Scholar]
  5. Cunningham S, McMurray A. Observational study of two oxygen saturation targets for discharge in bronchiolitis. Arch Dis Child. 2012;97(4):361–363. doi: 10.1136/adc.2010.205211. [DOI] [PubMed] [Google Scholar]
  6. Fernandes RM, Bialy LM, Vandermeer B. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev. 2010;10:CD00487–8. doi: 10.1002/14651858.CD004878.pub3. [DOI] [PubMed] [Google Scholar]
  7. Gadomski AM, Brower M. Bronchodilators for bronchiolitis. Cochrane Database Syst Rev. 2010;12:CD00126–6. doi: 10.1002/14651858.CD001266.pub2. [DOI] [PubMed] [Google Scholar]
  8. Hammer J, Numa A, Newth CJL. Acute respiratory distress syndrome induced by respiratory syncytial virus. Pediatr Pulmonol. 1997;23:176–183. doi: 10.1002/(SICI)1099-0496(199703)23:3<176::AID-PPUL2>3.0.CO;2-M. [DOI] [PubMed] [Google Scholar]
  9. Hall CB, Weinberg GA, Iwane MK. The burden of respiratory syncytial virus infection in young children. N Engl J Med. 2011;360(6):588–598. doi: 10.1056/NEJMoa0804877. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kimpen JLL, Hammer J. Bronchiolitis in infants. Eur Respir Mon. 2006;37:170–190. [Google Scholar]
  11. Midulla F, Scagnolari C, Bonci E. Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants. Arch Dis Child. 2011;95(1):35–41. doi: 10.1136/adc.2008.153361. [DOI] [PubMed] [Google Scholar]
  12. Levin D, Tribuzio M, Green-Wrzesinki T. Empiric antibiotics are justified for infants with respiratory syncytial virus lower respiratory tract infection presenting with respiratory failure: a prospective study and evidence review. Pediatr Crit Care Med. 2010;11(3):390–395. doi: 10.1097/PCC.0b013e3181b809c5. [DOI] [PubMed] [Google Scholar]
  13. Wainwright C. Acute viral bronchiolitis in children - a very common condition with few therapeutic options. Paediatr Respir Rev. 2010;11(1):39–45. doi: 10.1016/j.prrv.2009.10.001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wright M, Piedimonte G. Respiratory syncytial virus prevention and therapy: past, present, and future. Pediatr Pulmonol. 2011;46(4):324–347. doi: 10.1002/ppul.21377. [DOI] [PubMed] [Google Scholar]

Obstruktive Bronchitis

  1. Brand PL, Baraldi E, Bisgaard H. Definition, assessment and treatment of wheezing disorders in preschool children: an evidencebased approach. Eur Respir J. 2008;32(4):1096–1110. doi: 10.1183/09031936.00002108. [DOI] [PubMed] [Google Scholar]
  2. Bush A. Diagnosis of asthma in children under five. Prim Care Respir J. 2007;16:7–15. doi: 10.3132/pcrj.2007.00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ducharme FM, Lemire C, Noya FJ. Preemptive use of high-dose fluticasone for virus-induced wheezing in young children. N Engl J Med. 2009;360:339–353. doi: 10.1056/NEJMoa0808907. [DOI] [PubMed] [Google Scholar]
  4. Frey U, von Mutius E. The challenge of managing wheezing in infants. N Engl J Med. 2009;360:2130–2133. doi: 10.1056/NEJMe0902242. [DOI] [PubMed] [Google Scholar]
  5. Kieninger E, Fuchs O, Latzin P. Rhinovirus infections in infancy and early childhood. Eur Respir J. 2013;41(2):443–52. doi: 10.1183/09031936.00203511. [DOI] [PubMed] [Google Scholar]
  6. Leonardi NA, Spycher BD, Strippoli MP. Validation of the Asthma Predictive Index and comparison with simpler clinical prediction rules. J Allergy Clin Immunol. 2011;127:1466–1472. doi: 10.1016/j.jaci.2011.03.001. [DOI] [PubMed] [Google Scholar]
  7. Panickar JR, Grigg J. Controversies in the management of preschool viral wheeze. Paediatr Respir Rev. 2006;7:293–298. doi: 10.1016/j.prrv.2006.04.010. [DOI] [PubMed] [Google Scholar]
  8. Panickar J, Lakhanpaul M, Lambert PC. Oral prednisolone for preschool children with acute virus-induced wheezing. N Engl J Med. 2009;360:329–338. doi: 10.1056/NEJMoa0804897. [DOI] [PubMed] [Google Scholar]
  9. Robertson CF, Price D, Henry R. Short-course montelukast for intermittent asthma in children: a randomized controlled trial. Am J Respir Crit Care Med. 2007;175(4):323–329. doi: 10.1164/rccm.200510-1546OC. [DOI] [PubMed] [Google Scholar]

Asthma bronchiale

  1. Bisgaard H, Bonnelykke K. Long-term studies of the natural history of asthma in childhood. J Allergy Clin Immunol. 2010;126:187–197. doi: 10.1016/j.jaci.2010.07.011. [DOI] [PubMed] [Google Scholar]
  2. Cookson W, Moffatt M, Strachan DP. Genetic risks and childhood-onset asthma. J Allergy Clin Immunol. 2011;128(2):266–70. doi: 10.1016/j.jaci.2011.06.026. [DOI] [PubMed] [Google Scholar]
  3. de Groot EP, Duiverman EJ, Brand PL. Comorbidities of asthma during childhood: possibly important, yet poorly studied. Eur Respir J. 2010;36(3):671–8. doi: 10.1183/09031936.00185709. [DOI] [PubMed] [Google Scholar]
  4. Ege MJ. Exposure to environmental microorganisms and childhood asthma. N Engl J Med. 2011;364(8):701–9. doi: 10.1056/NEJMoa1007302. [DOI] [PubMed] [Google Scholar]
  5. Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature. 2008;454(7203):445–54. doi: 10.1038/nature07204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Holgate ST. Innate and adaptive immune responses in asthma. Nat Med. 2012;18(5):673–83. doi: 10.1038/nm.2731. [DOI] [PubMed] [Google Scholar]
  7. Jackson DJ, Gangnon RE, Evans MD. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008;178(7):667–72. doi: 10.1164/rccm.200802-309OC. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jorgensen IM. Asthma Mortality in the Danish Child Population. Pediatr Pulmonol. 2003;36:142–147. doi: 10.1002/ppul.10305. [DOI] [PubMed] [Google Scholar]
  9. Lai CKW. Global variation in the prevalence and severity of asthma symptoms. Thorax. 2009;64(6):476–83. doi: 10.1136/thx.2008.106609. [DOI] [PubMed] [Google Scholar]
  10. Ogden CL. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006;295(13):1549–55. doi: 10.1001/jama.295.13.1549. [DOI] [PubMed] [Google Scholar]
  11. Pearce N. Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC) Thorax. 2007;62:758–766. doi: 10.1136/thx.2006.070169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Phelan P. The Melbourne Asthma Study: 1964-1999. Journal Allergy Clin Immunol. 2002;109(2):189–94. doi: 10.1067/mai.2002.120951. [DOI] [PubMed] [Google Scholar]
  13. Scholtens S, et al. Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age. J Allergy Clin Immunol. 2009;123(6):1312–8. doi: 10.1016/j.jaci.2009.02.029. [DOI] [PubMed] [Google Scholar]
  14. Thomson NC, Chaudhuri R. Asthma in smokers: challenges and opportunities. Curr Opin Pulm Med. 2009;15(1):39–45. doi: 10.1097/MCP.0b013e32831da894. [DOI] [PubMed] [Google Scholar]
  15. www.ginasthma.com

Klinik

  1. Agache I et al. Untangling asthma phenotypes and endotypes. Allergy 2012 [DOI] [PubMed]
  2. Anderson SD. How does exercise cause asthma attacks? Current Opinion in Allergy and Clinical Immunology. 2006;6:37–42. doi: 10.1097/01.all.0000199797.02423.78. [DOI] [PubMed] [Google Scholar]
  3. Becker JM. Asthma deaths during sports: report of a 7-year experience. J Allergy Clin Immunol. 2004;113:264–267. doi: 10.1016/j.jaci.2003.10.052. [DOI] [PubMed] [Google Scholar]
  4. Bousquet J, Mantzouranis E, Cruz AA. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol. 2010;126:926–938. doi: 10.1016/j.jaci.2010.07.019. [DOI] [PubMed] [Google Scholar]
  5. Brand PL. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J. 2008;32(4):1096–110. doi: 10.1183/09031936.00002108. [DOI] [PubMed] [Google Scholar]
  6. Busse WW, Lemanske RF, Jr., Gern JE. Role of viral respiratory infections in asthma and asthma exacerbations. Lancet. 2010;376(9743):826–34. doi: 10.1016/S0140-6736(10)61380-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Guilbert TW. Identifying and managing the infant and toddler at risk for asthma. J Allergy Clin Immunol. 2010;126(2):417–22. doi: 10.1016/j.jaci.2010.06.024. [DOI] [PubMed] [Google Scholar]
  8. Hedlin G, Bush A, Lødrup Carlsen K. Problematic severe asthma in children, not one problem but many: a GA2LEN initiative. Eur Respir J. 2010;36(1):196–201. doi: 10.1183/09031936.00104809. [DOI] [PubMed] [Google Scholar]
  9. Illi S. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet. 2006;368(9537):763–70. doi: 10.1016/S0140-6736(06)69286-6. [DOI] [PubMed] [Google Scholar]
  10. Korn S, Hübner M, Hamelmann E. Buhl R. The German Severe Asthma Registry. Pneumologie. 2012;66(6):341–4. doi: 10.1055/s-0032-1308908. [DOI] [PubMed] [Google Scholar]
  11. Randoph C. Exercise-induced Bronchospasm in Children. Clinic Rev Allerg Immunol. 2008;34:205–216. doi: 10.1007/s12016-007-8035-0. [DOI] [PubMed] [Google Scholar]
  12. Regamey N, Casaulta Aebischer C. Frey U. Acute asthma attacks in childhood. Ther Umsch. 2005;62(8):539–42. doi: 10.1024/0040-5930.62.8.539. [DOI] [PubMed] [Google Scholar]
  13. Rosenstein N. The common cold-principles of judicious use of antimicrobial agents. Pediatrics. 1998;101(1):181–184. [Google Scholar]

Diagnostik

  1. Empfehlungen zur Behandlung der obstruktiven Atemwegserkrankungen im Kindesalter (SGPP/PIA 2009 Schweiz) Paediatrica. 2009;20(3):44–50. [Google Scholar]
  2. Nationale Versorgungsleitlinie Asthma Langfassung, 2. Auflage, Version 1.3, Juli 2011, http://www.versorgungsleitlinien.de/themen/asthma/pdf/nvl_asthma_lang.pdf
  3. Österreichische Leitlinien - Riedler et al. Wien Klin Wochenschr 2008

Therapie

  1. Global Initiative for Asthma (GINA). The Global Strategy for Asthma Management and Prevention. 2007 [cited: 2010 Nov 19]. Available from: http://www.ginasthma.com/download.asp?intId=309
  2. Kleine-Tebbe J et al. Die spezifische Immuntherapie (Hyposensibilisierung) bei IgE-vermittelten allergischen Erkrankungen, Leitlinien der Deutschen Gesellschaft Allergologie und klinische Immunologie (DGAKI), des Ärzteverbandes Deutscher Allergologen (ÄDA), der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA), der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI) und der Schweizerischen Gesellschaft für
  3. Allergologie und Immunologie (SGAI) Allergo J. 2009;18:508–37. [Google Scholar]
  4. Lemanske RF, Jr, Mauger DT, Sorkness CA. Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute: Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med. 2010;362:975–85. doi: 10.1056/NEJMoa1001278. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Nationale Versorgungsleitlinie Asthma Langfassung, 2. Auflage, Version 1.3, Juli 2011, http://www.versorgungsleitlinien.de/themen/ asthma/pdf/nvl_asthma_lang.pdf
  6. National Heart, Lung and Blood Institute (NHLBI). Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Full Report 2007. 2007 [cited: 2010 Nov 19]. Available from: http:// www.nhlbi.nih.gov/guidelines/asthma/asthgdln.pdf
  7. Riedler J, Eber E, Frischer T. Leitlinie zur Behandlung des Asthma bronchiale bei Kindern und Jugendlichen. Wien Klin Wochenschr. 2008;120:54–60. doi: 10.1007/s00508-007-0924-y. [DOI] [PubMed] [Google Scholar]
  8. Roth S, Barrazzone C, Barben J. Empfehlungen zur Behandlung der obstruktiven Atemwegserkrankungen im Kindesalter (SGPP/ PIA-CH 2009) Paediatrica. 2009;20:44–51. [Google Scholar]

Krupp-Syndrom/Epiglottitis

  1. Bjornson CL, Johnson DW. Croup. Lancet. 2008;371:329–339. doi: 10.1016/S0140-6736(08)60170-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bjornson C, Russel KF, Vandermeer B. Nebulized epinephrine for croup in children. Cochrane Database Syst Rev. 2011;16(2):CD00661–9. doi: 10.1002/14651858.CD006619.pub2. [DOI] [PubMed] [Google Scholar]
  3. Moore M. Little P Humidified air inhalation for treating croup: a systematic review and meta-analysis. Fam Pract. 2007;24(4):295–301. doi: 10.1093/fampra/cmm022. [DOI] [PubMed] [Google Scholar]
  4. Nicolai T, von Mutius E. Risk of asthma in children with a history of croup. Acta Paediatr. 1996;85:1295–1299. doi: 10.1111/j.1651-2227.1996.tb13914.x. [DOI] [PubMed] [Google Scholar]
  5. Roorda RJ, Walhof CM. Effect of inhaled fluticasone propionate administered with metered dose inhaler and spacer in mild to moderate croup: a negative preliminary report. Pediatric Pulmonology. 1998;25:114–117. doi: 10.1002/(SICI)1099-0496(199802)25:2<114::AID-PPUL7>3.0.CO;2-N. [DOI] [PubMed] [Google Scholar]
  6. Russell KF, Liang Y, O´Gorman K. Glucocorticoids for croup. Cochrane Database Syst Rev. 2011;19(1):CD00195–5. doi: 10.1002/14651858.CD001955.pub3. [DOI] [PubMed] [Google Scholar]
  7. Van Bever HP, Wieringa, Weyler JJ. Croup and recurrent croup: their association with asthma and allergy. An epidemiological study on 5-8-year-old children. Eur. J Pediatr. 1999;158:253–257. doi: 10.1007/s004310051062. [DOI] [PubMed] [Google Scholar]
  8. Waisman Y, Klein BL, Boenning DA. Prospective randomized double-blind study comparing L-epinephrine and racemic epinephrine aerosols in the treatment of laryngotracheitis (croup) Pediatrics. 1992;89:302–306. [PubMed] [Google Scholar]

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