Skip to main content
Springer Nature - PMC COVID-19 Collection logoLink to Springer Nature - PMC COVID-19 Collection
. 2006;581:281–284. doi: 10.1007/978-0-387-33012-9_47

Interaction Between the Spike Protein of Human Coronavirus NL63 and its Cellular Receptor ACE2

Stefan Pöhlmann 3, Thomas Gramberg 4, Anja Wegele 5, Krzysztof Pyrc 6, Lia van der Hoek 7, Ben Berkhout 8, Heike Hofmann 9
Editors: Stanley Perlman1, Kathryn V Holmes2
PMCID: PMC7123575  PMID: 17037543

The content is available as a PDF (732.0 KB).

Contributor Information

Stanley Perlman, Email: Stanley-Perlman@uiowa.edu

Kathryn V. Holmes, Email: Kathryn.Holmes@ucHSC.edu

References

  • 1.van der Hoek L, et al. Identification of a new human coronavirus. Nat. Med. 2004;10:368. doi: 10.1038/nm1024. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Holmes KV. The Coronaviridae. In: Knipe D, editor. Fields Virology. Philadelphia: Lippincott Wiliams & Wilkins; 2001. pp. 1187–1203. [Google Scholar]
  • 3.Stadler K, et al. SARS-beginning to understand a new virus. Nat. Rev. Microbiol. 2003;1:209. doi: 10.1038/nrmicro775. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Gallagher TM, Buchmeier MJ. Coronavirus spike proteins in viral entry and pathogenesis. Virology. 2001;279:371. doi: 10.1006/viro.2000.0757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Hofmann H, Pöhlmann S. Cellular entry of the SARS coronavirus. Trends Microbiol. 2004;12:466. doi: 10.1016/j.tim.2004.08.008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Kuo L, et al. Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: crossing the host cell species barrier. J. Virol. 2000;74:1393. doi: 10.1128/JVI.74.3.1393-1406.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Yeager CL, et al. Human aminopeptidase N is a receptor for human coronavirus 229E. Nature. 1992;357:420. doi: 10.1038/357420a0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Hofmann H, et al. S-protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients. J. Virol. 2004;78:6134. doi: 10.1128/JVI.78.12.6134-6142.2004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9.Moore MJ, et al. Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2. J. Virol. 2004;78:10628. doi: 10.1128/JVI.78.19.10628-10635.2004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Simmons G, et al. Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry. Proc. Natl. Acad. Sci. USA. 2004;101:4240. doi: 10.1073/pnas.0306446101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.Yang ZY, et al. pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN. J. Virol. 2004;78:5642. doi: 10.1128/JVI.78.11.5642-5650.2004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12.Fouchier RA, et al. A previously undescribed coronavirus associated with respiratory disease in humans. Proc. Natl. Acad. Sci. USA. 2004;101:6212. doi: 10.1073/pnas.0400762101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.Tresnan DB, Holmes KV. Feline aminopeptidase N is a receptor for all group I coronaviruses. Adv. Exp. Med. Biol. 1998;440:69. doi: 10.1007/978-1-4615-5331-1_9. [DOI] [PubMed] [Google Scholar]
  • 14.Li W, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003;426:450. doi: 10.1038/nature02145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15.Wang P, et al. Expression cloning of functional receptor used by SARS coronavirus. Biochem. Biophys. Res. Commun. 2004;315:439. doi: 10.1016/j.bbrc.2004.01.076. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Wong SK, et al. A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J. Biol. Chem. 2004;279:3197. doi: 10.1074/jbc.C300520200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Bonavia A, et al. Identification of a receptor-binding domain of the spike glycoprotein of human coronavirus HCoV-229E. J. Virol. 2003;77:2530. doi: 10.1128/JVI.77.4.2530-2538.2003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Breslin JJ, et al. Human coronavirus 229E: receptor binding domain and neutralization by soluble receptor at 37 degrees. J. Virol. 2003;77:4435. doi: 10.1128/JVI.77.7.4435-4438.2003. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Nidoviruses are provided here courtesy of Nature Publishing Group

RESOURCES