Abstract
It has been shown that a single parenteral administration of vaccine containing bacterial ligands for TLR1, TLR2, TLR4, TLR6, and TLR9 in mice induced rapid (24 h after administration) and effective (100%), but short-term (96 h) protection against lethal challenge with Salmonella typhimurium. Repeated mucosal applications of this vaccine stimulated long-term (up to 9 months) protection against acute respiratory infections in children of preschool age.
Keywords: Innate Immunity, Avian Influenza, Avian Influenza Virus, Acute Respiratory Infection, Lethal Challenge
Contributor Information
Michael R. Shurin, Email: shurinmr@upmc.edu
Yuri S. Smolkin, Email: smolking@dataforce.net
Boris Semenov, Email: mech.inst@mail.ru.
Vitaly Zverev, Email: mech.inst@mail.ru.
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